Role of Antiproliferative B Cell Translocation Gene-1 as an Apoptotic Sensitizer in Activation-Induced Cell Death of Brain Microglia

Lee, Heasuk; Cha, Sang-Hoon; Lee, Myung-Shik; Cho, Gyeong Jae; Choi, Wan Sung; Suk, Kyoungho

doi:10.4049/jimmunol.171.11.5802

Cited by 69 publications

(60 citation statements)

References 53 publications

(59 reference statements)

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“…Moreover, H37Rv, but not H37Ra, inhibits apoptosis in vitro [82] and causes exacerbated necrosis in Mf in vitro [83]. Apoptosis sensitizer gene BTG1, synergistically enhanced by LPS and IFN-g, has been implicated in activation-induced apoptosis [84].…”

Section: Immunosuppressionmentioning

confidence: 99%

Combination of host susceptibility and Mycobacterium tuberculosis virulence define gene expression profile in the host

Beisiegel¹,

Mollenkopf²,

Hahnke³

et al. 2009

Eur J Immunol

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Progression and outcome of tuberculosis is governed by extensive crosstalk between pathogen and host. Analyses of global changes in gene expression during immune response to infection with Mycobacterium tuberculosis (M.tb) can help identify molecular markers of disease state and progression. Global distribution of M.tb strains with different degrees of virulence and drug resistance, especially for the immunocompromised host, make closer analyses of host responses more pressing than ever. Here, we describe global transcriptional responses of inducible nitric oxide synthase-deficient (iNOS -/-) and WT mice infected with two related M.tb strains of markedly different virulence, namely the M.tb laboratory strains H37Rv and H37Ra. Both hosts exhibited highly similar resistance to infection with H37Ra. In contrast, iNOS -/-mice rapidly succumbed to H37Rv, whereas WT mice developed chronic course of disease. By differential analyses, virulence-specific changes in global host gene expression were analyzed to identify molecular markers characteristic for chronic versus acute infection. We identified several markers unique for different stages of disease progression and not previously associated with virulencespecific host responses in tuberculosis.

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Section: Immunosuppressionmentioning

confidence: 99%

Combination of host susceptibility and Mycobacterium tuberculosis virulence define gene expression profile in the host

Beisiegel¹,

Mollenkopf²,

Hahnke³

et al. 2009

Eur J Immunol

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“…Interestingly, BTG1 expression was previously shown to be induced in microglia via activation of the Janus-activated kinase/signal transducers and activators of transcription pathway (25). In that case, BTG1 expression was associated with the inhibition of proliferation.…”

Section: Discussionmentioning

confidence: 93%

“…BTG1 is expressed predominantly in quiescent cells at the G 0 /G 1 phase transition, with levels declining as cells enter S phase (24). Exogenous expression of BTG1 resulted in reduced proliferation with G 1 arrest and/or apoptosis in several cell types, including NIH3T3 murine fibroblasts (18,24), microglia (25), and myoblasts (26). A role for BTG1 in cellular differentiation has been proposed based on experiments showing that BTG1 expression stimulates myoblast differentiation (26), and that BTG1 is up-regulated in leukemic cells upon treatment with chemicals that induce differentiation (27).…”

Section: Discussionmentioning

confidence: 99%

B cell translocation gene 1 contributes to antisense Bcl-2-mediated apoptosis in breast cancer cells

Nahta

Yuan

Fiterman

et al. 2006

Molecular Cancer Therapeutics

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The antiapoptotic protein Bcl-2 is overexpressed in a majority of breast cancers, and is associated with a diminished apoptotic response and resistance to various antitumor agents. Bcl-2 inhibition is currently being explored as a possible strategy for sensitizing breast cancer cells to standard chemotherapeutic agents. Antisense Bcl-2 oligonucleotides represent one method for blocking the antiapoptotic effects of Bcl-2. In this study, we show that antisense Bcl-2 efficiently blocks Bcl-2 expression, resulting in the apoptosis of breast cancer cells. Antisense Bcl-2-mediated cytotoxicity was associated with the induction of the B cell translocation gene 1 (BTG1 ). Importantly, knockdown of BTG1 reduced antisense Bcl-2-mediated cytotoxicity in breast cancer cells. Furthermore, BTG1 expression seems to be negatively regulated by Bcl-2, and exogenous expression of BTG1 induced apoptosis. These results suggest that BTG1 is a Bcl-2-regulated mediator of apoptosis in breast cancer cells, and that its induction contributes to antisense Bcl-2-mediated cytotoxic effects. [Mol Cancer Ther 2006;5(6):1593 -601]

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“…BTG is a nuclear gene that has been implicated in cell differentiation processes including proliferation of microglia and their sensitivity to apoptogenic agents (Lee et al, 2003). BTG primers used here amplified a BTG-like sequence in all oyster species examined.…”

Section: ) B Cell Translocation Gene (Btg)mentioning

confidence: 99%

Transferability of Cupped Oyster EST (Expressed Sequence Tag)-Derived SNP (Single Nucleotide Polymorphism) Markers to Related Crassostrea and Ostrea Species

Kim¹,

Jung²,

Shin³

et al. 2014

The Korean Journal of Malacology

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Single nucleotide polymorphisms (SNPs) are widely acknowledged as the marker of choice for many genetic and genomic applications because they show co-dominant inheritance, are highly abundant across genomes and are suitable for high-throughput genotyping. Here we evaluated the applicability of SNP markers developed from Crassostrea gigas and C. virginica expressed sequence tags (ESTs) in closely related Crassostrea and Ostrea species. A total of 213 putative interspecific level SNPs were identified from re-sequencing data in six amplicons, yielding on average of one interspecific level SNP per seven bp. High polymorphism levels were observed and the high success rate of transferability show that genic EST-derived SNP markers provide an efficient method for rapid marker development and SNP discovery in closely related oyster species. The six EST-SNP markers identified here will provide useful molecular tools for addressing questions in molecular ecology and evolution studies including for stock analysis (pedigree monitoring) in related oyster taxa.

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Role of Antiproliferative B Cell Translocation Gene-1 as an Apoptotic Sensitizer in Activation-Induced Cell Death of Brain Microglia

Cited by 69 publications

References 53 publications

Combination of host susceptibility and Mycobacterium tuberculosis virulence define gene expression profile in the host

Combination of host susceptibility and Mycobacterium tuberculosis virulence define gene expression profile in the host

B cell translocation gene 1 contributes to antisense Bcl-2-mediated apoptosis in breast cancer cells

Transferability of Cupped Oyster EST (Expressed Sequence Tag)-Derived SNP (Single Nucleotide Polymorphism) Markers to Related Crassostrea and Ostrea Species

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