Role of Antioxidants on the Clinical Outcome of Patients with Perennial Allergic Rhinitis

Chauhan, Bhushan; Gupta, Manish; Chauhan, Komal

doi:10.2500/ar.2016.7.0163

Cited by 6 publications

(8 citation statements)

References 41 publications

(55 reference statements)

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“…Recent investigations indicate a role of antioxidants/supplements in the treatment of asthma and allergic rhinitis [ 28 , 29 ]. To further investigate this benefit for allergic rhinitis, we performed a double-blind, placebo-controlled study using a sulforaphane-based antioxidant We chose validated Peak Nasal Inspiratory Flow (PNIF) and Total Nasal Symptom Score (TNSS) to measure the four cardinal features of allergic rhinitis: nasal congestion, rhinorrhea, sneezing and ocular/nasal itching [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Broccoli Sprout Extract on Seasonal Grass Pollen-Induced Allergic Rhinitis

et al. 2021

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Patients exposed to pollutants are more likely to suffer from allergic rhinitis and may benefit from antioxidant treatment. Our study determined if patients diagnosed with grass-induced allergic rhinitis could benefit from broccoli sprout extract (BSE) supplementation. In total, 47 patients were confirmed with grass-induced allergic rhinitis and randomized to one of four groups: group 1 (nasal steroid spray + BSE), group 2 (nasal steroid spray + placebo tablet), group 3 (saline nasal spray + BSE) and group 4 (saline nasal spray + placebo tablet). Peak Nasal Inspiratory Flow (PNIF), Total Nasal Symptoms Scores (TNSS) and nasal mucus cytokine levels were analyzed in samples collected before and after the 3-week intervention. Comparing before and after the intervention, PNIF improved significantly when comparing Groups 1 and 2, vs. placebo, at various time points (p ≤ 0.05 at 5, 15, 60 and 240 min) following nasal challenge, while TNSS was only statistically significant at 5 (p = 0.03), 15 (p = 0.057) and 30 (p = 0.05) minutes. There were no statistically significant differences in various cytokine markers before and after the intervention. Combining nasal corticosteroid with BSE led to the most significant improvement in objective measures.

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Section: Discussionmentioning

confidence: 99%

“…The addition of an antioxidant to conventional nasal corticosteroid therapy for allergic rhinitis was proven beneficial in an open-label study [ 29 ]. Our study confirms these findings through analysis of PNIF.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Broccoli Sprout Extract on Seasonal Grass Pollen-Induced Allergic Rhinitis

et al. 2021

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“…The subjects were randomly allocated into three groups: T0 (Placebo), received starch capsules; T1 (Treatment 1), receiving Ginkgo biloba capsules 60 mg twice a day; and T2 (Treatment 2), receiving Ginkgo biloba capsules 60 mg twice a day along with antioxidant preparation (β-carotene [provitamin A] 20 mg, vitamin C [ascorbic acid] 200 mg, vitamin E 200 mg, and selenium 50 µg). Antioxidant preparation was used from our earlier study [ 15 ].…”

Section: Methodsmentioning

confidence: 99%

Ginkgo biloba Administered Singly and Combined With Antioxidants in Tinnitus Patients

2023

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Background and Objectives: Tinnitus, or ear ringing, involves impulsive and spontaneous activity in the auditory neurons. Its prevalence is high in the elderly, but 10%–15% of adults suffer from tinnitus, affecting their quality of life. Therefore, this study aimed to evaluate the efficacy of Ginkgo biloba administered singly and in combination with antioxidants in tinnitus patients.Subjects and Methods: Patients were randomly allocated to Placebo (T0, n=22), Treatment 1 (T1, n=24), and Treatment 2 (T2, n=23) groups. The patients were educated on the study’s methodology and were instructed to visit at 0, 4, 8, 12, and 14 weeks. The placebo group received starch capsule supplements. Conversely, the treatment groups received Ginkgo biloba (60 mg twice a day) singly and in combination with antioxidants. We enrolled 69 patients aged 40–70 years (41 men, 28 women). The Tinnitus Handicap Index (THI), Visual Analogue Score (VAS), and Short Form 36 (SF-36) Health Scores were determined pre- and post-treatment at each visit.Results: Supplementation of Ginkgo biloba, along with antioxidants, provided marked improvement (p<0.05) in post-treatment THI and VAS scores in the T2 group compared to those in the T1 and T0 groups. The greatest (p<0.05) percent difference was observed in the pre- and post-treatment THI (-36%) and VAS scores (-22.6%) of T2 patients. Likewise, the SF-36 scores improved significantly (p<0.05) in the T2 group in varied parameters.Conclusions: Ginkgo biloba, along with antioxidants, can be a promising therapy for tinnitus patients, providing marked improvement in THI, VAS, and SF-36 scores.

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“…Antioxidants [38] Antioxidants usually do not trigger nasal discomfort or drug uptake. As portion of the formulated design programmed, chemical / physical interactions of antioxidants and preservatives should be regarded with medication, excipients, manufacturing machinery and packaging elements.…”

Section: Formulation Phmentioning

confidence: 99%

“…[49] A pipette or a squeezed tube can be supplied to the nasal drops. [34][35][36][37][38][39] These are generally suggested for local circumstances, but difficulties include microbial development, mucociliar dysfunction and unspecified nose or neck reduction. [49] A piston and a tube working actuator are the nasal spray devices.…”

Section: Systems Of Nasal Drug Delivery Nasal Drops and Spraysmentioning

confidence: 99%

Nasal Route: A Breakthrough for Drug Delivery

Chattopadhyay¹,

Chakraborty²,

Maity³

et al. 2022

Journal of Pharmaceutical Negative Results

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Development and discovery are the two important parameters of evolution. With the progress of pharmaceutical science and technology, the empirical route of nose still remains one main attraction for the formulation of scientists. The nasal route has the capability to cover both topical and systematic delivery. The most important part of this route is that we can target the brain also. The extent to which a medicine may penetrate the Blood Brain Barrier is one of the factors that restricts the capacity of most treatments to treat illnesses of the Central Nervous System (CNS) (BBB). Tight junctions found in the endothelial cells of blood capillaries to the brain serve as a barrier to most medications and prevent them from passing through. The BBB successfully prevents hydrophilic substances from moving from the circulatory compartment to the brain tissue. Tight junctions between the cells prevent bulk passage across the capillary walls, unlike in other tissues. Nasal drug delivery strategies have emerged during the last few decades, some of which may be able to circumvent the difficulties in getting medications to cross the BBB. Various neuro-degenerative disorders like migraine, Parkinson’s disease, Alzheimer's disease, etc. can be targeted with that particular path. This article will bring light on several features, strategies, and obstacles of this pathway. Also, there are several dosage forms and their evaluation is provided. During the preclinical studies, there are several models like can be designed in in-vivo evaluation of nasal dosage form. Among all others models, the dog model has so many advantages and well suited for performing any trial related intranasal drug delivery.

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Role of Antioxidants on the Clinical Outcome of Patients with Perennial Allergic Rhinitis

Abstract: ABSTRACT

Cited by 6 publications

References 41 publications

The Effect of Broccoli Sprout Extract on Seasonal Grass Pollen-Induced Allergic Rhinitis

The Effect of Broccoli Sprout Extract on Seasonal Grass Pollen-Induced Allergic Rhinitis

Ginkgo biloba Administered Singly and Combined With Antioxidants in Tinnitus Patients

Nasal Route: A Breakthrough for Drug Delivery

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