Role of Antimicrobial Peptides in Inflammatory Bowel Disease

Otte, Jan-Michel; Vordenbäumen, Stefan

doi:10.3390/polym3042010

Cited by 14 publications

(11 citation statements)

References 35 publications

(41 reference statements)

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“…Fish, similar to mammals, produce many different AMPs (Figure 1) with antibacterial, anti-viral and anti-fungal activities (reviewed by Rajanbabu & Chen, 2011 [49]). Importantly, AMPs shape the composition of the microbial communities associated with mucosal surfaces in mammals and limit the extent of microorganism colonization [50]. Due to the importance of AMPs in mucosal immunity and in controlling commensals and pathogens, the current status on fish AMPs in the context of mucosal immune tissues is presented here.…”

Section: Innate Immunity At Teleost Mucosal Surfacesmentioning

confidence: 99%

The mucosal immune system of fish: The evolution of tolerating commensals while fighting pathogens

Gómez

Sunyer

Salinas

2013

Fish & Shellfish Immunology

600

367

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The field of mucosal immunology research has grown fast over the past few years, and our understanding on how mucosal surfaces respond to complex antigenic cocktails is expanding tremendously. With the advent of new molecular sequencing techniques, it is easier to understand how the immune system of vertebrates is, to a great extent, orchestrated by the complex microbial communities that live in symbiosis with their hosts. The commensal microbiota is now seen as the “extended self” by many scientists. Similarly, fish immunologist are devoting important research efforts to the field of mucosal immunity and commensals. Recent breakthroughs on our understanding of mucosal immune responses in teleost fish open up the potential of teleosts as animal research models for the study of human mucosal diseases. Additionally, this new knowledge places immunologists in a better position to specifically target the fish mucosal immune system while rationally designing mucosal vaccines and other immunotherapies. In this review, an updated view on how teleost skin, gills and gut immune cells and molecules, function in response to pathogens and commensals is provided. Finally, some of the future avenues that the field of fish mucosal immunity may follow in the next years are highlighted.

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Section: Innate Immunity At Teleost Mucosal Surfacesmentioning

confidence: 99%

The mucosal immune system of fish: The evolution of tolerating commensals while fighting pathogens

Gómez

Sunyer

Salinas

2013

Fish & Shellfish Immunology

600

367

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“…Immunoglobulin is an important component of the immune system and plays an important role in the process of immune regulation and mucosal defense (Zhao et al, 2013 ). Antibacterial peptides are essential peptides for maintaining intestinal barrier function and immune homeostasis (Otte and Vordenbäumen, 2011 ), and they can effectively fight against a variety of pathogens (Brogden et al, 2003 ). Many clinical studies have proven that low levels of immune molecules (such as immunoglobulins and antimicrobial peptides) are closely related to occurrence of various intestinal diseases.…”

Section: Introductionmentioning

confidence: 99%

“…The lack of secretory IgA in intestine leads to gastrointestinal mucositis and necrotizing colitis (Corthésy, 2013 ). Impaired production of IgA and defensins can cause inflammatory bowel diseases such as Crohn's disease (Otte and Vordenbäumen, 2011 ). In contrast, high levels of antimicrobial peptides in animals can enhance disease resistance.…”

Section: Introductionmentioning

confidence: 99%

Proper cold stimulation starting at an earlier age can enhance immunity and improve adaptability to cold stress in broilers

Xin

et al. 2020

Poultry Science

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The effects of long-term cold stimulation on the immune function of ileum and adaptability to cold stress in broilers were examined. A total of 360 Arbor Acres broilers was divided into 3 groups and four replicates per group. C (control) was reared in normal thermal environment. C-3 and C-12 (treatments) were kept in cold condition of 3 or 12°C lower than the temperature of C from days 8 to 42. At day 42, all the groups were exposed to an acute cold stress challenge, designated as S, S-3, and S-12. The mRNA levels of immune molecules and heat shock proteins as well as oxidative stress-related indicators in ileum tissues, and immunoglobulins contents in serum were examined at 14, 42, and 43 d of age. The C-3 regimen had no adverse effect on production performance, whereas the C-12 regimen reduced the production performance relative to C ( P < 0.05). At day 42, C-3 had higher levels of immune indexes ( P < 0.05), whereas C-12 had lower levels than C ( P < 0.05). No differences in levels of oxidative stress-related indicators were found between C and C-3 at day 42 ( P > 0.05). S-3 had higher levels of immune indexes and lower levels of oxidative stress-related indicators ( P < 0.05), as compared to S and S-12. The results suggest that 34 d of cold stimulation at 3°C lower than the normal temperature had no adverse impacts on production performance but enhanced the immunity of ileum and adaptability to acute cold challenge in broilers.

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“…There is still some uncertainty concerning the role of AMPs in IBD. Some studies demonstrate attenuated expression of certain peptides in small intestinal CD, suggesting that this decrease in expression might be an initiating factor in CD [99]. Others explain the observed downregulation of ileal defensins as a result of changes in cell type composition and differentiation, which may be an indirect effect of intestinal inflammation [98,100].…”

Section: Barrier Function In Ibdmentioning

confidence: 99%

Intestinal barrier homeostasis in inflammatory bowel disease

Goll

Granlund²

2014

Scandinavian Journal of Gastroenterology

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The single-cell thick intestinal epithelial cell (IEC) lining with its protective layer of mucus is the primary barrier protecting the organism from the harsh environment of the intestinal lumen. Today it is clear that the balancing act necessary to maintain intestinal homeostasis is dependent on the coordinated action of all cell types of the IEC, and that there are no passive bystanders to gut immunity solely acting as absorptive or regenerative cells: Mucin and antimicrobial peptides on the epithelial surface are continually being replenished by goblet and Paneth's cells. Luminal antigens are being sensed by pattern recognition receptors on the enterocytes. The enteroendocrine cells sense the environment and coordinate the intestinal function by releasing neuropeptides acting both on IEC and inflammatory cells. All this while cells are continuously and rapidly being regenerated from a limited number of stem cells close to the intestinal crypt base. This review seeks to describe the cell types and structures of the intestinal epithelial barrier supporting intestinal homeostasis, and how disturbance in these systems might relate to inflammatory bowel disease.

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Role of Antimicrobial Peptides in Inflammatory Bowel Disease

Cited by 14 publications

References 35 publications

The mucosal immune system of fish: The evolution of tolerating commensals while fighting pathogens

The mucosal immune system of fish: The evolution of tolerating commensals while fighting pathogens

Proper cold stimulation starting at an earlier age can enhance immunity and improve adaptability to cold stress in broilers

Intestinal barrier homeostasis in inflammatory bowel disease

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