Abstract:The disease, Leishmaniasis is a forlorn, tropical, vector-borne disease caused by the kinetoplast protozoan, an obligate intracellular parasite of the class Leishmania, which is transmitted by the nibble of female sandfly (Phlebotomus). Leishmaniasis is an incurable rare disease, since the organism developed resistance towards the currently used drugs, including pentavalent antimonials, amphotericin B and miltefosine. The mechanisms involved in drug resistance include reduced expression and mutations in AQP1, … Show more
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