Decubitus ulcers are important health problems and one of the maintrials that health organization facingevery day. Now a day various innovative modality of wound treatmenthave been endorsed including wound care. Recently, application of topical insulin helpsin healing ofdecubitus ulcers. Therefore, the aim of this study was to investigate the efficacy of applying topical insulin therapy in healing processof decubitus ulcers in immobilized patients.Design: ARandomized control trial research design was conducted in Neurological and Medical Departments at Alexandria Main University Hospital. Subjects: this study composed of 60 patients divided into two equal groups, study group who receive topical insulin dressing and control group who receive routine hospital dressing. Results, indicates significant improvement in decubitus ulcers healing forthe study group compared control to their where p value (˂0.05)Conclusion, topical application of insulin has a very powerful effect in healing process for decubitus ulcers. Recommendation: in service education program for nurses working in neurological and medical departments