Role of anterior segment optical coherence tomography angiography in the assessment of acute chemical ocular injury: a pilot animal model study

Tey, Kai Yuan; Gan, Jinyuan; Foo, Valencia Hui Xian; Tan, Bingyao; Ke, Meng Yuan; Schmetterer, Leopold; Ang, Marcus

doi:10.1038/s41598-021-96086-0

Cited by 11 publications

(7 citation statements)

References 32 publications

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“…Hence, subgroup risk should be determined, with caution, and confirmed with studies having a larger sample of subgroups. Although the Roper-Hall classification defines a classic method, there are reports for using DUA 32 or even the use of fluorescein and/or indocyanine green angiography, in addition to angio-OCT. 37 , 38 Therefore, there is a need of more recent classifications to evaluate the outcomes of the current study, before comparing it with present literature.…”

Section: Discussionmentioning

confidence: 99%

Demographic, Clinical Profile and Management Outcomes of Ocular Chemical Injuries in Saudi Children

Al-Ghadeer¹,

Amry²,

Aldihan³

et al. 2022

OPTH

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Background Eye injuries in children due to chemicals constitute a medical emergency since they result in severe ocular damage. Objective To determine the factors and management outcomes of chemical burns in the eyes of Saudi children. The study was performed at a tertiary eye center in the Kingdom of Saudi Arabia. Methods Children aged 16 years and under who had ocular chemical burns from 2009 to 2021 were enrolled in a single-armed cohort study. Data collection was done on patient demographics, injury type, and previous treatment. A modified Roper-Hall classification was used to grade the ocular injuries. The research study revealed the outcome to be best-corrected visual acuity (BCVA), one year after presentation and management. Results This study included 185 eyes from 147 children with chemical burns. The main profile of this study comprised the following categories: male (72.1%), grade 4 injury (27.6%), injury by acid (57.1%), burns at home (66%), and first aid was given to (35.4%) of the children. One year after treatment, there were 58 (31.4%) eyes with BCVA from 20/20 to 20/60, 31 cases (16.8%) with BCVA from 20/60 to 20/200, and 86 (46.5%) cases with severe visual impairment (SVI). Treatments included the release of symblepharon in 34 (18.4%) eyes and amniotic membrane transplantation (AMT) in 27 (14.6%) eyes. Poor visual outcomes were correlated with chemical burn severity (RR = 1.45, P =0.04). First aid administration ( P = 0.86) and type of chemical (acid vs non-acid) ( P = 0.83) did not differ significantly in association with SVI at the one-year follow-up. Conclusion Visual outcomes of chemical burns in children were not promising even after one year of treatment. Public health initiatives are critical to prevent chemical burns in mitigating the poor visual prognosis.

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Section: Discussionmentioning

confidence: 99%

Demographic, Clinical Profile and Management Outcomes of Ocular Chemical Injuries in Saudi Children

Al-Ghadeer¹,

Amry²,

Aldihan³

et al. 2022

OPTH

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“…Anterior segment imaging was performed pre-operatively and post-operatively at week 1, month 1, month 3, and month 6 using a digital slit-lamp camera (Topcon ATE-600, Nikon Corp) with a standard diffuse illumination (×10 magnification, flash power 4) for colour photography. Next, AS-OCTA of the episcleral vessels in all cornealimbal quadrants was conducted using a previously described scan protocol ( 26 ), using a spectral domain optical coherence tomography system (Nidek RS-3000 Advance 2, Gamagori, Japan) with a central wavelength of 880 nm, axial resolution of 7 um and transverse resolution of 15 um (anterior segment module). The eye tracker function was deactivated for imaging acquisition.…”

Section: Methodsmentioning

confidence: 99%

Anterior Segment Optical Coherence Tomography Angiography Following Trabecular Bypass Minimally Invasive Glaucoma Surgery

Gan

Sng

et al. 2022

Front. Med.

Self Cite

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ObjectiveTo assess anterior segment optical coherence tomography angiography (AS-OCTA) imaging of the episcleral vessels before and after trabecular bypass minimally invasive glaucoma surgery (MIGS).DesignA prospective, clinical, single-centre, single-arm pilot feasibility study conducted at National University Hospital, Singapore.SubjectsPatients with primary glaucomatous optic neuropathy undergoing Hydrus Microstent (Ivantis Inc., Irvine, CA, USA) implantation, who require at least one intra-ocular pressure-lowering medication. One or two eyes per patient may be enrolled.MethodsWe performed AS-OCTA (Nidek RS-3000 Advance 2, Gamagori, Japan) pre- and up to 6 months post-MIGS implantation using a standard protocol in all cornealimbal quadrants, to derive episcleral vessel densities (VD) using a previously described technique.Main Outcome MeasuresEpiscleral VD pre- and post-surgery, in sectors with and without the implant.ResultsWe obtained serial AS-OCTA images in 25 eyes undergoing MIGS implantation (23 subjects, mean age 70.3 ± 1.5, 61% female) with mean preoperative intraocular pressure (IOP) of 15.5 mmHg ± 4.0. We observed reductions in postoperative episcleral VD compared to preoperative VD at month 1 (mean difference −3.2, p = 0.001), month 3 (mean difference −2.94, p = 0.004) and month 6 (mean difference −2.19, p = 0.039) in sectors with implants (overall 6 month follow-up, p = 0.011). No significant changes were detected in episcleral VD in the sectors without implants (p = 0.910).ConclusionIn our pilot study, AS-OCTA was able to detect changes in the episcleral VD following trabecular bypass MIGS, which may be a useful modality to evaluate surgical outcomes if validated in future studies.

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“…In a rabbit model where the chemical injury was induced in a graded manner in different quadrants of the eye, the changes in limbal vasculature were studied over a period of 1 month using AS-OCTA [55]. The fellow eyes were uninvolved and taken as controls.…”

Section: Pre-clinical Studiesmentioning

confidence: 99%

Role of Anterior Segment-Optical Coherence Tomography Angiography in Acute Ocular Burns

Kate

Basu

2022

Diagnostics

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Acute ocular burns have varied manifestations which require prompt diagnosis and management to prevent chronic sequelae. Of these, the detection of limbal ischemia poses a challenge because of the subjective nature of its clinical signs. Anterior segment optical coherence tomography angiography (AS-OCTA) offers an objective method of assessing ischemia in these eyes. This review provides an overview of the technology of AS-OCTA and its applications in acute burns. AS-OCTA generates images by isolating the movement of erythrocytes within blood vessels from sequentially obtained b-scans. Limbal ischemia manifests in these scans as absent vasculature and the extent of ischemia can be quantified using different vessel-related parameters. Of these, the density of vessels is most commonly used and correlates with the severity of the injury. Incorporation of the degree of ischemia in the classification of acute burns has been attempted in animal studies and its extension to human trials may provide an added dimension in determining the final prognosis of these eyes. Thus, AS-OCTA is a promising device that can objectively evaluate limbal ischemia. This will facilitate the identification of patients who will benefit from revascularization therapies and stem cell transplants in acute and chronic ocular burns, respectively.

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Role of anterior segment optical coherence tomography angiography in the assessment of acute chemical ocular injury: a pilot animal model study

Cited by 11 publications

References 32 publications

Demographic, Clinical Profile and Management Outcomes of Ocular Chemical Injuries in Saudi Children

Demographic, Clinical Profile and Management Outcomes of Ocular Chemical Injuries in Saudi Children

Anterior Segment Optical Coherence Tomography Angiography Following Trabecular Bypass Minimally Invasive Glaucoma Surgery

Role of Anterior Segment-Optical Coherence Tomography Angiography in Acute Ocular Burns

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