Role of angiotensinogen gene polymorphism on Helicobacter pylori infection-related gastric cancer risk in Japanese

Sugimoto, Mitsushige; Furuta, Takahisa; Shirai, Naohito; Kodaira, Chise; Nishino, Masafumi; Ikuma, Mutsuhiro; Sugimura, Haruhiko; Hishida, Akira

doi:10.1093/carcin/bgm074

Cited by 29 publications

(32 citation statements)

References 39 publications

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“…Previously, the relationship between genes in the renin-angiotensin system and the risk of gastric cancer was investigated (30)(31)(32)(33)(34). One study reported a correlation between the A-20C AGT polymorphism and an increased risk of gastric cancer (34). However, results of our study revealed no association between the AGT M235T polymorphism and gastric cancer risk.…”

Section: Discussioncontrasting

confidence: 70%

“…This is the first investigation into a possible correlation between a salt sensitivity gene and gastric carcinogenesis. Previously, the relationship between genes in the renin-angiotensin system and the risk of gastric cancer was investigated (30)(31)(32)(33)(34). One study reported a correlation between the A-20C AGT polymorphism and an increased risk of gastric cancer (34).…”

Section: Discussionmentioning

confidence: 99%

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Polymorphism of the salt sensitivity gene angiotensinogen and gastric cancer risk

et al. 2011

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Abstract.A high-salt diet is a risk factor for gastric cancers other than those caused by Helicobacter pylori. The angiotensinogen (AGT) M235T polymorphism has been associated with salt sensitivity. The aim of the present study was to clarify the association between the AGT M235T polymorphism and gastric cancer. The AGT M235T polymorphism was genotyped using PCR-RFLP analysis in 206 gastric cancers and 210 control biopsies. A logistic-regression analysis was performed to identify an odds ratio to determine whether a correlation exists between genetic polymorphism and risk in patients with gastric cancer as compared to the control samples. Statistical significance was determined using the Mann Whitney U and Chi-square tests. The genotype distribution was found to be MM=9 (4.4%), MT=57 (27.7%), and TT=140 (67.9%) in samples from patients with gastric cancer and MM=8 (3.8%), MT=60 (28.6%) and TT=142 (67.6%) in the control samples. The odds ratio of gastric cancer of the MM genotype associated with the T carrier was 1.0 (0.4-2.7) (P=0.95). The distribution pattern of AGT M235T polymorphism in the gastric cancer cases and controls was not found to be significantly different in this study. Thus, it can be concluded that other sites of AGT polymorphism or other salt sensitivity genes may be associated with gastric cancer.

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Section: Discussioncontrasting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Polymorphism of the salt sensitivity gene angiotensinogen and gastric cancer risk

et al. 2011

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“…Indeed, several epidemiological and experimental studies have indicated that RAS can influence H. pylori gastritis and the pathogenesis of DU and GAC. 25,26,27,28 Conclusions The present study demonstrates the existence of prominent components of RAS in the human gastric mucosa suggesting local production of angiotensins as well as an Ang II mediated impact on mucosal functions. …”

Section: Figurementioning

confidence: 67%

The expression of renin-angiotensin system components in the human gastric mucosa

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Elfvin

Helander

et al. 2010

J Renin Angiotensin Aldosterone Syst

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Introduction: The aim of the present study was to map the distribution of representative protein components of the renin-angiotensin system (RAS) in the human gastric mucosa. Materials and methods:Biopsies from the antral and corporal mucosa of healthy Helicobacter pylori negative and positive volunteers were assessed by histology, Western blot and immunohistochemistry for angiotensin II subtype 1 and 2 receptors (AT1R, AT2R) and other RAS components (angiotensinogen, renin, angiotensin converting enzyme, and neprilysin). Mucosal levels of myeloperoxidase (MPO) served as a protein marker of neutrophil infiltration.

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“…RCC risk in relation to genetic variants in AGT has not been previously studied; however, AGT has been linked with other cancers. Specifically, an increased risk of postmenopausal breast cancer was found in a Dutch population among homozygous carriers of the M allele of rs699 (M235T) (26); a significantly higher number of heterozygote carriers of rs5051 (À6G.A) were found among Czech men with colorectal cancer compared with healthy men of similar age (27), and an increased risk of H. pylori-related gastric cancer was observed in a Japanese population among carriers of the C allele of rs5050 (À20A.C) (28). Rs699 is located in exon 2 and encodes a methionine to threonine amino acid change, and rs5051 and rs5050 are both located in the promoter (Figure 1).…”

Section: Gandreotti Et Almentioning

confidence: 99%

Variants in blood pressure genes and the risk of renal cell carcinoma

et al. 2010

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Hypertension is a known risk factor for renal cell carcinoma (RCC), although the underlying biological mechanisms of its action are unknown. To clarify the role of hypertension in RCC, we examined the risk of RCC in relation to 142 single-nucleotide polymorphisms (SNPs) in eight genes having a role in blood pressure control. We analyzed 777 incident and histologically confirmed RCC cases and 1035 controls who completed an in-person interview as part of a multi-center, hospital-based case-control study in Central Europe. Genotyping was conducted with an Illumina GoldenGate Oligo Pool All assay using germ line DNA. Of the eight genes examined, AGT (angiotensinogen) was most strongly associated with RCC (minimum P-value permutation test 5 0.02). Of the 17 AGT tagging SNPs considered, associations were strongest for rs1326889 [odds ratio (OR) 5 1.35, 95% confidence interval (CI) 5 1.15-1.58] and rs2493137 (OR 5 1.31, 95% CI 5 1.12-1.54), which are located in the promoter. Stratified analysis revealed that the effects of the AGT SNPs were statistically significant in participants with hypertension or high body mass index (BMI) ( ‡25 kg/m 2 ), but not in subjects without hypertension and with a normal BMI (<25 kg/m 2 ). Also, haplotypes with riskconferring alleles of markers located in the promoter and intron 1 regions of AGT were significantly associated with RCC compared with the common haplotype in subjects with hypertension or high BMI (global P 5 0.003). Our findings suggest that common genetic variants of AGT, particularly those in the promoter, increase RCC risk among subjects who are hypertensive or overweight.

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Role of angiotensinogen gene polymorphism on Helicobacter pylori infection-related gastric cancer risk in Japanese

Abstract: The carriage of AGT-20 C allele was associated with an increased risk for H.pylori-related gastric cancer development in Japanese, indicating that the RA system plays an important role in the pathogenesis of gastric cancer.

Cited by 29 publications

References 39 publications

Polymorphism of the salt sensitivity gene angiotensinogen and gastric cancer risk

Polymorphism of the salt sensitivity gene angiotensinogen and gastric cancer risk

The expression of renin-angiotensin system components in the human gastric mucosa

Variants in blood pressure genes and the risk of renal cell carcinoma

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