Role of Angiotensin II Type 1A Receptor-Mediated Signaling in the Development of Pressure Overload-Induced Left Ventricular Hypertrophy and Fibrosis

Kim, Young Hwa; Son, Ju Hee; Piao, Hainan; Kwon, Jinhyeong; Bae, Jang Whan; Hwang, Kyung Kuk; Kim, Dong Ho; Cho, Myeong Chan

doi:10.4070/kcj.2006.36.9.626

Cited by 1 publication

(1 citation statement)

References 24 publications

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“…33) In this regard, angiotensin II has been recognized as a growth-promoting factor that contributes to structural alterations in various organs. [34][35][36][37] tensin III [Angiotensin (2)(3)(4)(5)(6)(7)(8)] is more lipid-soluble than is angiotensin II, and it is found in relatively high concentrations in the brain and cerebrospinal fluid. Angiotensin III is less potent than angiotensin II for eliciting biological responses.…”

Section: Angiotensinsmentioning

confidence: 99%

Overview of the Renin-Angiotensin System

Ryu

Kim

2007

Korean Circ J

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Angiotensin II is an octapeptide hormone of the renin-angiotensin system (RAS), and it regulates a wide variety of physiological responses including salt and water balance, the blood pressure and the vascular tone. Clinical trials with angiotensin-converting enzyme (ACE) inhibitors have demonstrated survival benefits in subjects with congestive heart failure and myocardial infarction, and this support the importance of angiotensin II in the pathogenesis of cardiovascular diseases. Through activation of small G proteins such as Ras, Rho, and Rac, angiotensin II induces remodeling of vascular smooth muscle cells (VSMC), including proliferation, migration, hypertrophy and inflammation. Angiotensin (1-7) appears to be the main effector peptide of ACE2 with vasodilatory, natriuretic and antiinflammatory properties. The cross-talk between the angiotensin II receptors may play an important role in maintaining cardiovascular homeostasis.

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