Role of angiomotin family members in human diseases (Review)

Abstract

Angiomotin (Amot) family members, including Amot, Amot-like protein 1 (Amotl1) and Amot-like protein 2 (Amotl2), have been found to interact with angiostatins. In addition, Amot family members are involved in various physiological and pathological functions such as embryonic development, angiogenesis and tumorigenesis. Some studies have also demonstrated its regulation in signaling pathways such as the Hippo signaling pathway, AMPK signaling pathway and mTOR signaling pathways. Amot family members play an important role in neural stem cell differentiation, dendritic formation and synaptic maturation. In addition, an increasing number of studies have focused on their function in promoting and/or suppressing cancer, but the underlying mechanisms remain to be elucidated. The present review integrated relevant studies on upstream regulation and downstream signals of Amot family members, as well as the latest progress in physiological and pathological functions and clinical applications, hoping to offer important ideas for further research. Contents1. Introduction 2. The structure of Amot family 3. Upstream and downstream regulation of the Amot family proteins 4. The role of Amot family proteins in physiological regulation 5. Role of Amot family proteins in cancer and other disease 6. Clinic application through targeting Amot family proteins 7. Conclusion and future directions