Role of angiogenic growth factors and inflammatory cytokine on recurrence of chronic subdural hematoma

Hong, Hyun Jong; Kim, Young Jin; Yi, Hyeong-Joong; Ko, Yong; Oh, Sea Cheon; Kim, Jae Min

doi:10.1016/j.surneu.2008.01.023

Cited by 111 publications

(91 citation statements)

References 22 publications

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“…Others have reported similar findings [6]. Higher levels of IL-6 in cSDH fluid and higher levels of VEGF and bFGF in the membranes have been reported in recurrent cSDHs when compared with nonrecurrent collections [7]. Katano, et al…”

Section: Discussionmentioning

confidence: 65%

Resolution of Chronic Subdural Hematoma after Treatment with Tumor Necrosis Factor Alpha Inhibitor

Ross¹

2011

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Section: Discussionmentioning

confidence: 65%

Resolution of Chronic Subdural Hematoma after Treatment with Tumor Necrosis Factor Alpha Inhibitor

Ross¹

2011

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“…In addition, traumatic subdural hygroma, defined as an accumulation of cerebrospinal fluid in the subdural space after trauma, is frequently associated with the development of CSDH (23). As a result, many coagulofibrinolytic factors, inflammatory cytokines, angiogenic growth factors, and highly specific proteins for CSF have been associated with CSDHs (3,7,8,12,22,32). We hypothesized that higher intensity head traumas prior to the CSDH may be associated with greater levels of these molecular markers, especially suggesting more CSF admixture into the subdural space.…”

Section: █ Discussionmentioning

confidence: 99%

“…Additionally, the roles of inflammatory, fibrinolytic, angiogenic, and coagulation-system factors in the CSDH have been investigated (3,7,8,12,22,32). Currently, CSDH is considered a chronic self-perpetuating inflammatory process involving the dura mater.…”

Section: Introductionmentioning

confidence: 99%

Chronic subdural hematoma preceded by high-impact trauma: does the intensity of trauma influence the pathogenesis of traumatic chronic subdural hematoma?

Park¹,

Lee²,

Park³

et al. 2015

Turkish Neurosurgery

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ABSTRACTof the meninges and the neo-membrane of hematoma have been recently clarified. Additionally, the roles of inflammatory, fibrinolytic, angiogenic, and coagulation-system factors in the CSDH have been investigated (3,7,8,12,22,32). Currently, CSDH is considered a chronic self-perpetuating inflammatory process involving the dura mater.Trauma is probably the most important risk factor for CSDH. Rupture of transversing veins by trauma is commonly known █ INTRODUCTION C hronic subdural hematoma (CSDH) is a commonly encountered neurosurgical disease that is more likely to occur under certain conditions, including advanced age, alcoholism, abnormal coagulation, dementia, seizure disorder, or after cerebrospinal fluid (CSF) diversion (13,17,18). Although the pathophysiology of CSDH has been controversial over the last several years, the ultrastructural anatomy AIm: The purpose of this study was to investigate whether the intensity of trauma influences the pathogenesis of traumatic chronic subdural hematoma (CSDH). mATERIAl and mEThODS: Thirty-one patients treated surgically for traumatic CSDH were divided into high-impact and lowimpact groups according to the intensity of trauma. They were respectively evaluated with respect to clinical and radiological findings at presentation, and the subdural concentrations of interleukin-6 (IL-6), interleukin-8 (IL-8), vascular endothelial growth factor (VEGF), basic fibroblast growth factor, and beta-trace protein (βTP) [a highly specific protein in the cerebrospinal fluid (CSF)] related to the pathogenesis of CSDH. If βTP (subdural fluid/serum) was >2, an admixture of CSF to the subdural fluid was indicated. RESUlTS:The βTP (subdural fluid/serum) was >2 in all patients with a traumatic CSDH. The mean concentration of subdural βTP in the high-impact group was higher than in the low-impact group (6.1 mg/L versus 3.9 mg/L), and the difference was statistically significant (p=0.02). In addition, mean concentrations of IL-6, IL-8 and VEGF were higher in the high-impact group, as compared to the low-impact group, though the differences did not reach statistical significance.CONClUSION: Trauma may be related to CSF leakage into the subdural space in CSDH, and the intensity of trauma may influence the amount of CSF leakage. Although there is no direct correlation between the amount of CSF leakage and other subdural molecules, the intensity of trauma may be associated with larger concentrations of molecules in traumatic CSDH.

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“…In our study, the value of IL-6 was 2549.0 ± 395.9 pg/ml or 1321.0 ± 258.8 pg/dl; the value of TNFa was 41.1 ± 8.8 pg/ml; and the value of IL-10 was 56.4 ± 96.4 pg/dl. 8,11,29,37) Our study design did not allow us to determine the role of inflammatory change in hematomas, but the markedly elevated levels of inflammatory and anti-inflammatory cytokines in hematomas were particularly interesting findings. Our patients did not have inflammatory basic diseases or immunological disorders, so the reasons for the markedly elevated levels of cytokines were unclear.…”

Section: Measurement Of Inflammatory Cytokines and Tm In Csdhmentioning

confidence: 99%

“…The CT appearance of the lesions were also evaluated. [3][4][5][6][7][8][9][10][11][12][13][14][15]. No patient had coagulopathy or systemic inflammatory changes detected by blood testing or in their past medical history.…”

Section: Introductionmentioning

confidence: 99%

Measurement of Inflammatory Cytokines and Thrombomodulin in Chronic Subdural Hematoma

Kitazono

Satoh

Onda

et al. 2012

Neurol. Med. Chir.(Tokyo)

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Inflammation and the coagulation system may influence the genesis of chronic subdural hematoma (CSDH). The appearance of CSDH on computed tomography (CT) varies with the stage of the hematoma. This study investigated the pathogenesis and the recurrence of CSDH by comparing cytokine levels with the CT features of CSDH in 26 patients with 34 CSDHs who underwent single burr-hole surgery at our hospital between October 2004 and November 2006. The hematoma components removed during the procedure were examined, and the hematoma serum levels of cytokines measured such as thrombomodulin (TM), interleukin-6 (IL-6), tumor necrosis factor-a (TNFa), and interleukin-10 (IL-10). Using CT, mixed density hematomas were distinguished from other homogeneous hematomas, and found that the TM level was significantly higher in mixed density hematomas than in homogeneous hematomas (p ＝ 0.043). Mixed density hematomas were classified into three subtypes (laminar, separated, and trabecular hematomas). The TM level was significantly higher in laminar and separated hematomas than in other hematomas (p ＝ 0.01). The levels of IL-6, TNFa, and IL-10 were extremely high, but showed no significant differences in relation to the CT features. Mixed density hematomas had high recurrence rate, as reported previously, and TM level was high in mixed density hematomas such as laminar and separated mixed density hematomas. The present findings suggest that the types of CSDH associated with high TM levels tend to have higher recurrence rate.

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Role of angiogenic growth factors and inflammatory cytokine on recurrence of chronic subdural hematoma

Cited by 111 publications

References 22 publications

Resolution of Chronic Subdural Hematoma after Treatment with Tumor Necrosis Factor Alpha Inhibitor

Resolution of Chronic Subdural Hematoma after Treatment with Tumor Necrosis Factor Alpha Inhibitor

Chronic subdural hematoma preceded by high-impact trauma: does the intensity of trauma influence the pathogenesis of traumatic chronic subdural hematoma?

Measurement of Inflammatory Cytokines and Thrombomodulin in Chronic Subdural Hematoma

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