Role of androgens in modulating male and female sexual function

Traish, Abdulmaged M.

doi:10.1515/hmbci.2010.052

Cited by 6 publications

(4 citation statements)

References 124 publications

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“…This group showed androgen levels in the normal range, and showed better sexual function and less sexual distress compared to the PCOS group. Based on the literature ( Traish, 2010 ; Wahlin-Jacobsen etal. , 2015 ; Davis etal.…”

Section: Discussionmentioning

confidence: 99%

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Sexual dysfunction in women with PCOS: a case control study

Pastoor,

Both,

Laan

et al. 2023

Human Reproduction

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STUDY QUESTION What is the relationship of sex steroid levels with sexual function in women with and without polycystic ovary syndrome (PCOS)? SUMMARY ANSWER Women with PCOS reported more sexual dysfunction and more sexual distress compared to those without PCOS, but only few and weak associations between androgen levels and sexual function were observed. WHAT IS KNOWN ALREADY The literature shows that women with PCOS report lower levels of sexual function and sexual satisfactionand more sexual distress. Contributing factors seem to be obesity, alopecia, hirsutism, acne, infertility, anxiety, depression, and low self-esteem. In women with PCOS clinical and/or biochemical hyperandrogenism is common; its relationship with sexualfunction is, however, inconclusive. STUDY DESIGN, SIZE, DURATION This observational prospective case control study with 135 women (68 PCOS, 67 control) was conductedfrom March 2017 until March 2020. PARTICIPANTS/MATERIALS, SETTING, METHODS Heterosexual women with and without PCOS, aged 18–40 years, in a steady relationshipand without any comorbidities, underwent an extensive medical and endocrine screening using liquid chromatography-tandem mass spectrometry and validated sexual function questionnaires. MAIN RESULTS AND THE ROLE OF CHANCE Women with PCOS reported significantly lower sexual function (Female Sexual Function Index (FSFI) P < 0.001, partial η2 = 0.104), higher levels of sexual distress (Female Sexual Distress Scale-Revised P < 0.001, partial η2 = 0.090), and they more often complied with the definition of sexual dysfunction (41.2% vs 11.9%, P < 0.001, Phi V = 0.331) and clinical sexual distress (51.5% vs 19.4%, P < 0.001, Phi V = 0.335). Regression analysis adjusted for confounders showed only few and weak associations between androgen levels and sexual function, with each model explaining a maximum of 15% sexual function. Following significant Group × Hormone interactions, analyses for both groups separately showed no significant associations in the PCOS group. The control group showed only weak negative associations between testosterone and FSFI pain (β = −6.022, P = 0.044, Adj R2 = 0.050), between FAI and FSFI orgasm (β = −3.360, P = 0.023, Adj R2 = 0.049) and between androstenedione and clinical sexual distress (β = −7.293, P = 0.036, exp(β) = 0.001). LIMITATIONS, REASONS FOR CAUTION The focus of the study on sexual functioning potentially creates selection bias. Possibly women with more severe sexual disturbances did or did not choose to participate. Differences between women with PCOS and controls in relationship duration and hormonal contraceptive use might have skewed the sexual function outcomes. WIDER IMPLICATIONS OF THE FINDINGS Sexual function is impaired in women with PCOS. However, endocrine perturbations seem to have minimal direct impact on sexual function. Addressing sexuality and offering psychosexual counseling is important in the clinical care for women with PCOS. STUDY FUNDING/COMPETING INTEREST(S) This study was funded by the departments of the participating centers: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Erasmus University Medical Center, Rotterdam, the Netherlands; Department of Psychosomatic OBGYN and Sexology, Leiden University Medical Center, Leiden, the Netherlands; and Department of Sexology and Psychosomatic OBGYN, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands. J.S.E.L. received unrestricted research grants from the following companies (in alphabetical order): Ansh Labs, Ferring, Merck Serono and Roche Diagnostics. He also received consultancy fees from Ansh Labs, Ferring, Titus Healthcare and Roche Diagnostics. The other authors have no conflicts of interest. TRIAL REGISTRATION NUMBER CCMO register, registration number: NL55484.078.16, 10 March 2016. https://www.toetsingonline.nl/to/ccmo_search.nsf/Searchform?OpenForm

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Section: Discussionmentioning

confidence: 99%

“…Sex-steroid hormones, in particular estrogens and androgens, play an important role in sexual function ( Traish, 2010 ; Davis etal. , 2016 ), although the exact mechanisms by which these steroids exert their influence are still unclear ( Davis etal.…”

Section: Introductionmentioning

confidence: 99%

Sexual dysfunction in women with PCOS: a case control study

Pastoor,

Both,

Laan

et al. 2023

Human Reproduction

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“…Development, growth and maintenance of urogenital organs in goats are under the influence of androgens, mainly testosterone hormone (Gofur et al, 2014;Traish et al, 2018). Androgens plays a role in the maintenance of penile tissue structural integrity, penile trabecular smooth muscle growth and function, integrity of penile nerve fiber network, signaling pathways in the corpora cavernosa, physiological penile response to stimuli, and facilitation of corporeal hemodynamics (Traish, 2010). Androgen deprivation leads to veno-occlusive dysfunction by causing structural, biochemical, and physiological alterations in cavernosal tissue of penis (Rogers et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Effect of testosterone on penile and urethral development in Black Bengal goat

Gofur

2020

BJVM

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Background: Testosterone is important for proper development, growth and functional maintenance of urogenital organs in animals.The objective of this study was to determine the effect of testosterone on penile and urethral development in Black Bengal goats. Methods: Nine male Black Bengal goats (4 months old) were divided into three groups (n=3); Group-A: goats with testosterone deficient (castrated at 4 months of age), Group-B: control and Group-C: goats with excess testosterone (exogenous IM administration of testosterone enanthate; @ 125 mg/goat weekly for a period of 2 months). After getting puberty (8 months of age), goats were slaughtered and penises collected with maximum precaution and hygienic practices, and morphometric examinations performed extensively. Results: The penis of testosterone deficient (castrated) goats was significantlyshorter and narrower in diameter/circumference compared to that ofcontrol goats (with adequate testosterone). Moreover, exogenous testosterone treated non-castrated goats resulted comparatively lager penis that the control goats.The urethral lumen was significantly larger in diameter in goats with adequate testosterone (control and exogenous testosterone-treated) than testosterone deficient goats. Conclusion:The results of this study indicate that the level of testosterone positively affects thenormal development of the penis and urethra in Black Bengal goats.

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“…Several animal studies suggested that androgens plays a role in the maintenance of penile tissue structural integrity, penile trabecular smooth muscle growth and function, integrity of penile nerve fiber network, signaling pathways in the corpora cavernosa, myogenic and adipogenic differentiation in the corpora cavernosa, physiological penile response to stimuli, and facilitation of corporeal hemodynamics ( Traish, 2010 ). Androgen deprivation leads to VOD by causing structural, biochemical, and physiological alterations in cavernosal tissue ( Rogers et al, 2003 ).…”

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confidence: 99%

The Effect of Testosterone Replacement Therapy on Penile Hemodynamics in Hypogonadal Men With Erectile Dysfunction, Having Veno-Occlusive Dysfunction

2018

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Hypogonadism may cause veno-occlusive dysfunction (VOD) by structural and biochemical alterations in the cavernosal tissue. The aim of the study was to investigate the effect of testosterone replacement therapy (TRT) on penile hemodynamics in hypogonadal men with erectile dysfunction and VOD.The study included 32 hypogonadal men with erectile dysfunction, having VOD. All patients underwent penile color Doppler ultrasonography (PCDU) at the beginning and 6 months after the initial evaluation. Erectile function was evaluated with the 5-item version of the International Index of Erectile Function (IIEF-5); hypogonadism was evaluated by testosterone measurement and the Aging Male Symptoms (AMS) scale. All patients received transdermal testosterone 50 mg/day for 6 months. Clinical and radiological findings were compared before and 6 months after the TRT.The mean age was 58.81 ± 4.56 (52–69) years. Mean total testosterone levels were 181.06 ± 39.84 ng/dL and 509.00 ± 105.57 ng/dL before and after the therapy, respectively (p < .001). While all patients had physiological serum testosterone levels (>320 ng/dL) after the therapy, three cases (9.3%) had no clinical improvement of hypogonadism symptoms. Cavernosal artery peak systolic velocity (PSV) and resistive index (RI) significantly increased, and end diastolic velocity (EDV) significantly decreased after TRT. VOD no longer existed in 21 (65.6%) of the cases.This study demonstrated that TRT may restore penile hemodynamics in hypogonadal men with VOD.

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Role of androgens in modulating male and female sexual function

Cited by 6 publications

References 124 publications

Sexual dysfunction in women with PCOS: a case control study

Sexual dysfunction in women with PCOS: a case control study

Effect of testosterone on penile and urethral development in Black Bengal goat

The Effect of Testosterone Replacement Therapy on Penile Hemodynamics in Hypogonadal Men With Erectile Dysfunction, Having Veno-Occlusive Dysfunction

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