Role of androgens in menstrual disorders of nonhirsute and hirsute women, and the effect of glucocorticoid therapy on androgen levels in hirsute hyperandrogenic women

Yuen, Basil Ho; Mincey, E.K.

doi:10.1016/0002-9378(83)90482-9

Cited by 20 publications

(5 citation statements)

References 2 publications

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“…Indeed raised serum androgen levels in non-hirsute women with PCO have been reported (Lloyd et al, 1966;Yuen et al, 1983). It has also been implied in a number of other studies, but often aclear distinction between those with and without hirsutism is not made (Kandeel et al, 1980;Horrocks et al, 1983).…”

Section: Discussionmentioning

confidence: 94%

The EFFECT OF ENDOGENOUS PROGESTERONE ON SERUM LEVELS OF 5α‐REDUCED ANDROGENS IN HIRSUTE WOMEN

Dewis¹,

Newman²,

Anderson³

1984

Clinical Endocrinology

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This study was to examine indirectly the effect of endogenous progesterone, a known competitor for 5 alpha-reductase, on androgen metabolism in target organs in hirsute women. Serum levels of progesterone, testosterone (T), androstenedione (A), dihydrotestosterone (DHT) and 5 alpha-androstane 3 alpha 17 beta-diol (3 alpha-diol) and sex hormone binding globulin (SHBG) were assessed serially over a four week period in normal women, six hirsute women with regular menstrual cycles, eight hirsute women with oligomenorrhoea (and presumptive polycystic ovaries) and seven non-hirsute women with oligomenorrhoea. Serum T and A levels were significantly higher than normal in both hirsute and non-hirsute women with oligomenorrhoea, while serum SHBG was significantly lower than normal in the two groups of hirsute women. The calculated free T level was higher than normal in all three groups of patients. DHT levels were not significantly different from normal in any of the three groups of patients. The 3 alpha-diol level showed considerable overlap with normal in all groups of patients and was only significantly higher than normal in hirsute women with oligomenorrhoea (P less than 0.05). There was a small fall in DHT in the late luteal phase of the cycle of those women with a sustained rise in serum progesterone in the second half of the cycle, but no change in serum 3 alpha-diol. These studies suggest that serum 3 alpha-diol may not be as good an indicator of peripheral androgen metabolism in hirsute women as previously reported and that a rise in serum progesterone has only a minimal effect on circulating levels of the active 5 alpha-reduced androgen metabolites. Although in vitro 3 alpha-diol has been shown to be a potent inhibitor of 5 alpha-reductase this casts doubt on its role in this regard in vivo.

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Section: Discussionmentioning

confidence: 94%

The EFFECT OF ENDOGENOUS PROGESTERONE ON SERUM LEVELS OF 5α‐REDUCED ANDROGENS IN HIRSUTE WOMEN

Dewis¹,

Newman²,

Anderson³

1984

Clinical Endocrinology

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“…Early studies favoured an appetite stimulating effect of androgens causing obesity (Hosseinian et al, 1976;Wild et al, 1983) although no direct data have accumulated to support this hypothesis (Rosenfield et a/., 1984). Other studies have proposed hypothalamic defects (Kopelman et al, 1980) or an adrenal source (Ho Yuen & Mincey, 1983) to account for the androgen excess in obesity.…”

Section: Obesitymentioning

confidence: 99%

Clinical implications of hyperinsulinaemia in women

Conway¹,

Jacobs²

1993

Clinical Endocrinology

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“…The latter combinations are often successful in inducing ovulation in women with hyperandrogenic anovulation or polycystic ovarian syndrome (PCO). [14][15][16] Bromocriptine remains the treatment of choice in hyperprolactinemic anovulation. Failure to respond or intolerance to these versatile first-line agents would be indications for exogenous gonadotropin therapy.…”

Section: Patient Selectionmentioning

confidence: 99%

Induction of Ovulation with Exogenous Gonadotropins in Anovulatory Infertile Women

Yuen¹,

Pride²

1990

Semin Reprod Med

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Role of androgens in menstrual disorders of nonhirsute and hirsute women, and the effect of glucocorticoid therapy on androgen levels in hirsute hyperandrogenic women

Cited by 20 publications

References 2 publications

The EFFECT OF ENDOGENOUS PROGESTERONE ON SERUM LEVELS OF 5α‐REDUCED ANDROGENS IN HIRSUTE WOMEN

The EFFECT OF ENDOGENOUS PROGESTERONE ON SERUM LEVELS OF 5α‐REDUCED ANDROGENS IN HIRSUTE WOMEN

Clinical implications of hyperinsulinaemia in women

Induction of Ovulation with Exogenous Gonadotropins in Anovulatory Infertile Women

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