Role of AMPK-regulated autophagy in retinal pigment epithelial cell homeostasis: A review
Liangliang Zhou,
Ya Mo,
Haiyan Zhang
et al.
Abstract:The retinal pigment epithelium (RPE) is a regularly arranged monolayer of cells in the outermost layer of the retina. It is crucial for transporting nutrients and metabolic substances in the retina and maintaining the retinal barrier. RPE dysfunction causes diseases related to vision loss. Thus, understanding the mechanisms involved in normal RPE function is vital. Adenosine monophosphate-activated protein kinase (AMPK) is an RPE energy sensor regulating various signaling and metabolic pathways to maintain cel… Show more
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