Role of Amniotic Membrane Transplantation in Acute Chemical Injury

Lo, Kristine; Kohanim, Sahar; Trief, Danielle; Chodosh, James

doi:10.1097/iio.0b013e31829ceec8

Cited by 10 publications

(7 citation statements)

References 46 publications

(46 reference statements)

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“…In our patient, conjunctival advancement would have been difficult due to the presence of scarred conjunctiva and we selected a mixed approach by transplanting a large and double patch of amniotic membrane to be a scaffold for a free conjunctival graft. The amnion presents anti-inflammatory properties and growth factors that prevent or decrease fibrosis in healing tissue [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Managing Drawbacks in Unconventional Successful Glaucoma Surgery: A Case Report of Stent Exposure

Fea

Cannizzo

Consolandi

et al. 2015

Case Reports in Ophthalmological Medicine

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Traditional options in managing failed trabeculectomy (bleb needling, revision, additional incisional surgery and tube surgery) have a relatively high failure and complication rate. The use of microinvasive glaucoma surgery (MIGS) has generally been reserved to mild to moderate glaucoma cases, proving good safety profiles but significant limitations in terms of efficacy. We describe a patient who underwent MIGS (XEN Aquesys subconjunctival shunt implantation) after a prior failed trabeculectomy. After the surgery, the IOP was well controlled but as the stent was close to an area of scarred conjunctiva of the previous trabeculectomy, it became partially exposed. As a complete success was achieved, we decided to remove the conjunctiva over the exposed area and replace it by an amniotic membrane transplantation and a conjunctiva autograft. Six months after surgery, the unmedicated IOP is still well controlled with complete visual acuity recovery.

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Section: Discussionmentioning

confidence: 99%

Managing Drawbacks in Unconventional Successful Glaucoma Surgery: A Case Report of Stent Exposure

Fea

Cannizzo

Consolandi

et al. 2015

Case Reports in Ophthalmological Medicine

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“…The amnion has also found relatively widespread application as a wound covering, with treatment for diabetic neurovascular ulcers, venous stasis ulcers, and various types of postsurgical and posttraumatic wound dehiscence [9][10][11][12][13]. Some examples include the use of amnion as a wound covering for burn wounds treated with split thickness skin grafts [14], for children with partialthickness facial burns [15], and various other clinical trials showing similar successes with various preparation and application methodologies [16][17][18][19]. These studies demonstrate that the use of amnion as a wound covering contributes to accelerated wound closure, reduced inflammation and scarring, reduced pain, and fewer infections.…”

Section: Introductionmentioning

confidence: 99%

Solubilized Amnion Membrane Hyaluronic Acid Hydrogel Accelerates Full-Thickness Wound Healing

Murphy

Skardal

Song

et al. 2017

Stem Cells Translational Medicine

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The early and effective treatment of wounds is vital to ensure proper wound closure and healing with appropriate functional and cosmetic outcomes. The use of human amnion membranes for wound care has been shown to be safe and effective. However, the difficulty in handling and placing thin sheets of membrane, and the high costs associated with the use of living cellularized tissue has limited the clinical application of amniotic membrane wound healing products. Here, we describe a novel amnion membrane-derived product, processed to result in a cell-free solution, while maintaining high concentrations of cell-derived cytokines and growth factors. The solubilized amnion membrane (SAM) combined with the carrier hyaluronic acid (HA) hydrogel (HA-SAM) is easy to produce, store, and apply to wounds. We demonstrated the efficacy of HA-SAM as a wound treatment using a full-thickness murine wound model. HA-SAM significantly accelerated wound closure through re-epithelialization and prevented wound contraction. HA-SAM-treated wounds had thicker regenerated skin, increased total number of blood vessels, and greater numbers of proliferating keratinocytes within the epidermis. Overall, this study confirms the efficacy of the amnion membrane as a wound treatment/dressing, and overcomes many of the limitations associated with using fresh, cryopreserved, or dehydrated tissue by providing a hydrogel delivery system for SAM. STEM CELLS

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“…22 The study reported complete healing of superficial partial burns within 7-10 days with the same successful result in mid-dermal burns within 20 days. Multiple clinical trials describe similar results with various amnion preparation and application methodologies [23][24][25] and there are multiple amnion-based commercial products, such as AmnioGraft-a cryopreserved amniotic membrane sheet, Epifix-dehydrated human amnion/chorion membrane sheet, and NuCel-a cryopreserved, liquid suspension derived from human amnion and amniotic fluid cells, among others.…”

Section: Introductionmentioning

confidence: 94%

Amnion membrane hydrogel and amnion membrane powder accelerate wound healing in a full thickness porcine skin wound model

Murphy

Skardal

Nelson

et al. 2019

Stem Cells Translational Medicine

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There is a need for effective wound treatments that retain the bioactivity of a cellular treatment, but without the high costs and complexities associated with manufacturing, storing, and applying living biological products. Previously, we developed an amnion membrane-derived hydrogel and evaluated its wound healing properties using a mouse wound model. In this study, we used a full thickness porcine skin wound model to evaluate the wound-healing efficacy of the amnion hydrogel and a less-processed amnion product comprising a lyophilized amnion membrane powder. These products were compared with commercially available amnion and nonamnion wound healing products. We found that the amnion hydrogel and amnion powder treatments demonstrated significant and rapid wound healing, driven primarily by new epithelialization versus closure by contraction. Histological analysis demonstrated that these treatments promote the formation of a mature epidermis and dermis with similar composition to healthy skin. The positive skin regenerative outcomes using amnion hydrogel and amnion powder treatments in a large animal model further demonstrate their potential translational value for human wound treatments.

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Role of Amniotic Membrane Transplantation in Acute Chemical Injury

Cited by 10 publications

References 46 publications

Managing Drawbacks in Unconventional Successful Glaucoma Surgery: A Case Report of Stent Exposure

Managing Drawbacks in Unconventional Successful Glaucoma Surgery: A Case Report of Stent Exposure

Solubilized Amnion Membrane Hyaluronic Acid Hydrogel Accelerates Full-Thickness Wound Healing

Amnion membrane hydrogel and amnion membrane powder accelerate wound healing in a full thickness porcine skin wound model

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