Role of aluminium sensitivity in delayed persistent immunisation reactions.

Abstract

Prognostic value of morphometry in breast cancer We completely agree with Dr Laroye and his colleagues that it is dangerous to draw any conclusions at all from the results ofa study of only 75 patients with breast cancer. The Multivariate Prognostic Index (MPI) was developed in an initial study of 271 patients'

Tetanus antigen modulates the gene expression profile of aluminum phosphate adjuvant in spleen lymphocytes in vivo

“…3 The immunostimulatory properties have not been fully characterized even for these aluminum-based adjuvants and undesired side effects have been reported for the administration site including erythema, subcutaneous nodules, contact hypersensitivity and granulomatous inflammation. 4 Recently, massive accumulation of aluminum in macrophages of muscle previously injected with aluminum-based adjuvants was associated with muscle ailment. 5 To our knowledge, the immunological and potential side effects of the aluminum phosphate adjuvant on a lymphoid tissue distant from the administration site have not been thoroughly investigated.…”

Safety of CpG Oligodeoxynucleotides in Veterinary Species

“…Furthermore, side effects, including erythema, subcutaneous nodules, contact hypersensitivity, and granulomatous inflammation, can occur from the use of alum adjuvants (Ross et al, 1991). Although little or no systemic toxicity is typically seen after using alum adjuvants in humans and most veterinary species, vaccination site-associated fibrosarcomas in do-mestic cats have been linked with aluminum adjuvants (Hendrick et al, 1992;Macy, 1999).…”