Role of Aldose Reductase in the Peritoneal Changes of Patients Undergoing Peritoneal Dialysis

Hasuike, Yukiko; Moriguchi, Rintarou; Hata, Reiko; Miyagawa, Koji; Kuragano, Takahiro; Aizawa, Masayo; Yamamoto, Satoshi; Yanase, Kimihiko; Izumi, Masayuki; Tanimoto, Tsuyoshi; Nakanishi, Takeshi

doi:10.1159/000108358

Cited by 4 publications

(2 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The potential mechanism of AR involvement in drug resistance could be due to increased drug metabolism or increased efflux or decreased permeability of drugs from the cells [104]. Various studies in different cancer cells such as human stomach carcinoma cells, lung cancer and liver cancer, suggest that increased expression of AR contributes to carbonyl reduction and increased detoxification [105-107]. Lee et al [108] reported that overexpression of AR caused resistance to doxorubicin in liver cancer cells and inhibition of AR reversed the drug resistance.…”

Section: Role Of Ar In Carcinogenesismentioning

confidence: 99%

Targeting Aldose Reductase for the Treatment of Cancer

Tammali

Srivastava²,

Ramana³

2011

CCDT

View full text Add to dashboard Cite

It is strongly established by numerous studies that oxidative stress-induced inflammation is one of the major causative agents in a variety of cancers. Various factors such as bacterial, viral, parasitic infections, chemical irritants, carcinogens are involved in the initiation of oxidative stress-mediated inflammation. Chronic and persistent inflammation promotes the formation of cancerous tumors. Recent investigations strongly suggest that aldose reductase [AR; AKR1B1], a member of aldo-keto reductase superfamily of proteins, is the mediator of inflammatory signals induced by growth factors, cytokines, chemokines, carcinogens etc. Further, AR reduced product(s) of lipid derived aldehydes and their metabolites such as glutathionyl 1,4-dihydroxynonanol (GS-DHN) have been shown to be involved in the activation of transcription factors such as NF-κB and AP-1 which transcribe the genes of inflammatory cytokines. The increased inflammatory cytokines and growth factors promote cell proliferation, a main feature involved in the tumorigenesis process. Inhibition of AR has been shown to prevent cancer cell growth in vitro and in vivo models. In this review, we have described the possible association between AR with oxidative stress- and inflammation- initiated carcinogenesis. A thorough understanding of the role of AR in the inflammation – associated cancers could lead to the use of AR inhibitors as novel chemotherapeutic agents against cancer.

show abstract

Section: Role Of Ar In Carcinogenesismentioning

confidence: 99%

Targeting Aldose Reductase for the Treatment of Cancer

Tammali

Srivastava²,

Ramana³

2011

CCDT

View full text Add to dashboard Cite

show abstract

“…Οι μθχανιςμοί επαγωγισ τθσ δράςθσ τθσ ALR2 ςε αυτζσ τισ περιπτϊςεισ δεν ζχουν μελετθκεί πλιρωσ αλλά πικανά περιλαμβάνουν εγκατάςταςθ οξειδωτικοφ ςτρεσ και ςυςςϊρευςθ ουραιμικϊν ουςιϊν και δικαρβονυλικϊν παραγϊγων. Θ επαγωγι τθσ δράςθσ τθσ ALR2, τουλάχιςτο εν μζρει, επθρεάηει τθν μεμβράνθ του περιτόναιου ςε αςκενείσ που υποβάλλονται ςε αιμοκάκαρςθ (Hasuike et al, 2007). Σε αυτζσ τισ περιπτϊςεισ βλαβϊν τθσ μεμβράνθσ του περιτόναιου με μορωολογικζσ αλλοιϊςεισ παρατθρείται μειωμζνθ λειτουργικότθτα, όπωσ για παράδειγμα απϊλεια τθσ ςπειραματικισ διικθςθσ.…”

Section: Alr2 and νεφρικέσ δυςλειτουργίεσunclassified