Role of AIF-1 in the regulation of inflammatory activation and diverse disease processes

Zhao, Yanying; Yan, Dongjing; Chen, Zhengwang

doi:10.1016/j.cellimm.2013.07.008

Cited by 84 publications

(71 citation statements)

References 57 publications

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“…Expression of Aif-1 increases above basal levels in these cell types (16)(17)(18) in neuro-inflammatory disease models (19). Conceivably, increased expression of Aif-1 during EAE pathogenesis (20,21) could promote T cell, macrophage and/or microglial proinflammatory functions and overall disease activity.…”

Section: Discussionmentioning

confidence: 99%

“…Aif-1 is differentially expressed in various mouse and human tissues (14,15) and in multiple leukocyte types including macrophages and T cells at basal levels (16)(17)(18). In inflammatory disease models, upregulated Aif-1 expression has been reported in microglia, macrophages, T cells, synoviocytes, pancreatic β-cells and adipocytes under various pathological conditions representing encephalomyelitis, uveitis, neuritis, arteriopathies, arthritis and diabetes, respectively (19).…”

Section: Loss Of Allograft Inflammatory Factor-1 Ameliorates Experimementioning

confidence: 99%

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Loss of Allograft Inflammatory Factor-1 Ameliorates Experimental Autoimmune Encephalomyelitis by Limiting Encephalitogenic CD4 T-Cell Expansion

Chinnasamy

Lutz

Riascos-Bernal

et al. 2015

Mol Med

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Section: Discussionmentioning

confidence: 99%

Section: Loss Of Allograft Inflammatory Factor-1 Ameliorates Experimementioning

confidence: 99%

Loss of Allograft Inflammatory Factor-1 Ameliorates Experimental Autoimmune Encephalomyelitis by Limiting Encephalitogenic CD4 T-Cell Expansion

Chinnasamy

Lutz

Riascos-Bernal

et al. 2015

Mol Med

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“…Allograft inflammatory factor-1 (AIF-1) is a calcium-binding inflammation related scaffold protein mainly produced by immune cells [8]. It was firstly identified in activated macrophages in rat cardiac allografts with chronic rejection (GenBank accession number U17919) [9].…”

Section: Introductionmentioning

confidence: 99%

Allograft Inflammatory Factor-1 Mediates Macrophage-Induced Impairment of Insulin Signaling in Adipocytes

Ren¹,

Lin²,

Tang³

et al. 2018

Cell Physiol Biochem

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Background/Aims: Allograft inflammatory factor-1 (AIF-1) is an inflammatory cytokine produced mainly by macrophages within human white adipose tissue. Its expression is increased in obese subjects and positively correlated with insulin resistance. The purpose of this study is to characterize the regulatory role of AIF-1 in insulin signaling of adipocyte. Methods: AIF-1 was over-expressed via transfection of AIF-1 cDNA into murine RAW 264.7 macrophages, and the constitutive expression of AIF-1 was decreased via transfection of targeting siRNA. Murine 3T3L1 adipocytes were treated with macrophage-conditioned medium or AIF-1 protein. Intracellular lipid accumulation was assayed by oil red O stain. Reactive oxygen species production was determinated by a flow cytometer and adipokine secretion was measured with ELISA. Glucose uptake was detected using the glucose oxidase method and insulin-signal-transduction related molecules were analyzed by Western blot. Results: Short term (48 h) AIF-1 treatment slightly promoted intracellular lipid storage in differentiating 3T3L1 cells. The protein stimulated reactive oxygen species production, provoked TNFα, IL6, resistin, but suppressed adiponectin release and insulin-stimulated glucose uptake both under normal basal and insulin resistance conditions. Furthermore, AIF-1 induced NF-κB activation, inhibited PPARγ expression, GLUT4 translocation to plasma membrane and Akt phosphorylation. Conclusion: Macrophage-derived AIF-1 up-regulated reactive oxygen species production, adipokine TNFα, IL6, resistin release, and inhibited adiponectin secretion. Moreover, it suppressed insulin-stimulated glucose uptake by down-regulating insulin signaling. Thus, AIF-1 could be related to obesity-related diseases.

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“…33,34) and is overexpressed in human mammary tumors and cervical cancer tissues (18,35). Overexpression of IBA1 promotes the proliferation of human breast cancer cells and facilitates tumor growth in female nude mice (10,18). These results indicate that IBA1 may function as an oncogene.…”

Section: Discussionmentioning

confidence: 89%

“…Daintain (also known as IBA1 or AIF-1) is closely associated with cardiac allograft vasculopathy (4-6), rheumatoid arthritis (7), inflammatory skin disorders (8), systemic sclerosis (9,10), and central nervous system injury (11)(12)(13). Furthermore, IBA1 plays important roles in the initiation and progression of cancers, including breast cancer (14)(15)(16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

EF Hand Protein IBA2 Promotes Cell Proliferation in Breast Cancers via Transcriptional Control of Cyclin D1

Zhang

Wang

2016

Cancer Research

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EF hand (EFh) domain-containing proteins have been implicated in malignant progression, but their precise functional contributions are uncertain. Here, we report evidence that the EFh protein IBA2 promotes the proliferation of breast cancer cells by facilitating their transit through the G 1 -S cell-cycle transition. Mechanistic investigations revealed that IBA2 acted at the transcriptional level to promote the expression of the critical cell-cycle regulator cyclin D1. Clinically, we found that levels of IBA2 were significantly upregulated in breast cancer specimens, where its expression correlated positively with histologic grade. Our results suggest a key role for IBA2 in mammary tumorigenesis.Cancer Res; 76(15); 4535-45. Ó2016 AACR.

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Role of AIF-1 in the regulation of inflammatory activation and diverse disease processes

Cited by 84 publications

References 57 publications

Loss of Allograft Inflammatory Factor-1 Ameliorates Experimental Autoimmune Encephalomyelitis by Limiting Encephalitogenic CD4 T-Cell Expansion

Loss of Allograft Inflammatory Factor-1 Ameliorates Experimental Autoimmune Encephalomyelitis by Limiting Encephalitogenic CD4 T-Cell Expansion

Allograft Inflammatory Factor-1 Mediates Macrophage-Induced Impairment of Insulin Signaling in Adipocytes

EF Hand Protein IBA2 Promotes Cell Proliferation in Breast Cancers via Transcriptional Control of Cyclin D1

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