Role of advanced MR imaging modalities in diagnosing cerebral gliomas

Scarabino, Tommaso; Popolizio, Teresa; Trojsi, Francesca; Giannatempo, G.M.; Pollice, Saverio; Maggialetti, Nicola; Carriero, Alessandro; Costanzo, Alfonso Di; Tedeschi, G.; Salvolini, U.

doi:10.1007/s11547-008-0351-9

Cited by 16 publications

(10 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several authors have demonstrated the usefulness of employing short TE (35 msec) rather than long TE (144 msec) sequences on high-field MR spectroscopy in grading cerebral gliomas, when only the intratumoral region was taken into account [26]. This was also confirmed from our study.…”

Section: Discussionsupporting

confidence: 85%

“…In particular, in highgrade gliomas, Cho was elevated in the peritumoral edema, while NAA was reduced in the periphery [26]. Similarly, Server et al, using long TE (135 msec) 1 H-MRS, observed elevation in peritumoral Cho/Cr and Cho/NAA metabolic ratios in relation to grading.…”

Section: Discussionmentioning

confidence: 99%

“…Advanced MR imaging techniques, such as 1 H-MRS, can further improve the diagnostic accuracy during tumor grading [13, 24, 25] up to approximately 15% [26]. 1 H-MRS provides information on the biochemical profile of a tissue and is increasingly being used as a noninvasive method for the detection and grading of brain tumors [27].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Spectroscopic Evaluation of Glioma Grading at 3T: The Combined Role of Short and Long TE

Kousi

Tsougos

Tsolaki

et al. 2012

The Scientific World Journal

View full text Add to dashboard Cite

Purpose. To evaluate the diagnostic value of 3T 1H-MRS in grading cerebral gliomas using short and long echo times. Methods. 1H-MRS was performed on 71 patients with untreated cerebral gliomas. Metabolite ratios of NAA/Cr, Cho/Cr, Cho/NAA, and mI/Cr were calculated for short and long TE and compared between low and high grade gliomas. Lipids were qualitatively evaluated. ROC analysis was performed to obtain the cut-off values for the metabolic ratios presenting statistical difference between the two glioma grades. Results. Intratumoral Cho/Cr at both TEs and long TE Cho/NAA were significantly different between low and high grade gliomas. Peritumoral NAA/Cr of both TEs, as well as long TE Cho/Cr and Cho/NAA ratios, significantly differentiated the two tumor grades. Diagnostic sensitivity of peritumoral short TE NAA/Cr proved to be superior over the other metabolic ratios, whereas intratumoral short TE Cho/Cr reached the highest levels of specificity and accuracy. Overall, short TE 1H-MRS reached higher total sensitivity in predicting glioma grade, over long TE. Conclusion. An advantage was found in using short TE over long TE 1H-MRS in the discrimination of low versus high grade gliomas. Moreover, the results suggested that the peritumoral area of gliomas may be more valuable in predicting glioma grade than using only the intratumoral area.

show abstract

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Spectroscopic Evaluation of Glioma Grading at 3T: The Combined Role of Short and Long TE

Kousi

Tsougos

Tsolaki

et al. 2012

The Scientific World Journal

View full text Add to dashboard Cite

show abstract

“…Several studies have reported that apparent diffusion coefficient (ADC) maps, which indicate the magnitude of the diffusion of water molecules within cerebral tissue obtained from several diffusion‐weighted images, may be useful for preoperative grading . However, the role of ADC maps in differentiating between low‐grade and high‐grade gliomas has been disputed . A number of studies have shown that reduced ADC values can be clearly detected in high‐grade gliomas .…”

Section: Introductionmentioning

confidence: 99%

Glioma grading using apparent diffusion coefficient map: application of histogram analysis based on automatic segmentation

et al. 2014

View full text Add to dashboard Cite

The accurate diagnosis of glioma subtypes is critical for appropriate treatment, but conventional histopathologic diagnosis often exhibits significant intra-observer variability and sampling error. The aim of this study was to investigate whether histogram analysis using an automatically segmented region of interest (ROI), excluding cystic or necrotic portions, could improve the differentiation between low-grade and high-grade gliomas. Thirty-two patients (nine low-grade and 23 high-grade gliomas) were included in this retrospective investigation. The outer boundaries of the entire tumors were manually drawn in each section of the contrast-enhanced T1 -weighted MR images. We excluded cystic or necrotic portions from the entire tumor volume. The histogram analyses were performed within the ROI on normalized apparent diffusion coefficient (ADC) maps. To evaluate the contribution of the proposed method to glioma grading, we compared the area under the receiver operating characteristic (ROC) curves. We found that an ROI excluding cystic or necrotic portions was more useful for glioma grading than was an entire tumor ROI. In the case of the fifth percentile values of the normalized ADC histogram, the area under the ROC curve for the tumor ROIs excluding cystic or necrotic portions was significantly higher than that for the entire tumor ROIs (p < 0.005). The automatic segmentation of a cystic or necrotic area probably improves the ability to differentiate between high- and low-grade gliomas on an ADC map.

show abstract

“…However, studies investigating the capacity of MRI to delineate the tumor boundaries of gliomas are scarce. Some studies used image-guided tumor biopsy or postmortem specimens for correlation and reported on discrepancies between the real tumor extent and findings by MRI (37)(38)(39)(40).…”

Section: Discussionmentioning

confidence: 99%

Novel membrane-permeable contrast agent for brain tumor detection by MRI

et al. 2010

View full text Add to dashboard Cite

One of the key challenges hindering the clinical intervention against brain cancer is defined by the inability to detect brain tumors at an early enough stage to permit effective therapy. Furthermore, the rapid growth and severe lethality of this form of cancer predicate the vital importance of monitoring the development of the pathology and its outcome after therapeutic intervention. With this in mind, we designed a novel membrane-permeant contrast agent, MN-MPAP-Cy5.5, which consists of a superparamagnetic iron oxide core, for MRI conjugated to myristoylated polyarginine peptides, as a membrane translocation module and labeled with the near-infrared dye Cy5.5 for correlative microscopy. This probe showed a remarkable uptake by U-87 human glioma cells in vitro and localized and delineated stereotactically injected tumor in vivo by MRI. Our findings suggest that the agent mediates its effects by translocation of the magnetic nanoparticles label across the leaky tumor vasculature, followed by enhanced accumulation in tumor cells. The noninvasive detection of brain tumors when they are still small represents a formidable challenge from an imaging standpoint. Our study describes an improved strategy to detect brain lesions by utilizing a contrast agent with membrane translocation properties.

show abstract

Role of advanced MR imaging modalities in diagnosing cerebral gliomas

Cited by 16 publications

References 41 publications

Spectroscopic Evaluation of Glioma Grading at 3T: The Combined Role of Short and Long TE

Spectroscopic Evaluation of Glioma Grading at 3T: The Combined Role of Short and Long TE

Glioma grading using apparent diffusion coefficient map: application of histogram analysis based on automatic segmentation

Novel membrane-permeable contrast agent for brain tumor detection by MRI

Contact Info

Product

Resources

About