Role of adrenalin and blocking of α-receptors in responses of hematopoietic organs to stress

Gorizontov, P.D.; Белоусова, О Ю; Zimin, Yu. I.

doi:10.1007/bf00786192

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2023

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“…Immobilization stress was imitated by P.D.Horizontov method [6]. Later, the animals were decapitated; the level of LOPs and activity of antioxidant system enzymes were detected in lung homogenate on the 1 st , 2 nd , 34 th days of stress activity.…”

Section: Materials and Methods Of Investigationmentioning

confidence: 99%

Сondition of pro-oxidant and antioxidant systems in guinea pigs’ lungs under the condition of immobilization stress.

Baida,

Hot,

Antonenko

2023

J Educ Health Sport

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We have investigated the results of alterations in indices of pro-oxidant (conjugated diene and malondialdehyde ) and antioxidant (superoxide dismutase, ceruloplasmin, catalase) systems in guinea pigs’ lungs under the conditions of immobilization stress. The experiment was conducted on 40 female guinea pigs weighing 0.18-0.20 kg. The animals were divided into 4 groups, each contained 10 guinea pigs: I – intact guinea pigs ( control), II–guinea pigs with model of IS on1st day of experiment;Ш–animals on 2nd day of experiment;IV- group of animals on 34th day of experimental model of IS. The results of our experimental work showed a significant accumulation of lipid peroxidation products in the lung`s tissure in different periods ( on 1st, 2nd and 34th days) of immobilization stress. The state of antioxidant defence was characterized by moderate decrease of inzymes activity (superoxide dismutase, catalase and ceruloplasmin). disorders of balance between pro-oxidant and antioxidant systems couse oxidative stress development.

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Section: Materials and Methods Of Investigationmentioning

confidence: 99%