Role of Adrenal Medulla in Morphine‐induced Hyperthermia Through Central Action

Wallenstein, Martin C.

doi:10.1111/j.1476-5381.1982.tb09255.x

Cited by 9 publications

(1 citation statement)

References 14 publications

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“…One surprising finding is that the direct injection of deltorphin-II into the POAH produces hyperthermia, instead of hypothermia (Benamar et al , 2004). This outcome underscores how the thermoregulatory effects of delta opioid agonists, akin to agonists at kappa and mu opioid receptors, vary widely with the administration route and indicates delta opioid agonists act at both hypothalamic and extra-hypothalamic delta 2 receptors to produce changes in body temperature (Wallenstein, 1982). …”

Section: Opioid Effects On Body Temperaturementioning

confidence: 94%

Effects of opioids, cannabinoids, and vanilloids on body temperature

Benamar¹

2011

Front Biosci

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Cannabinoid and opioid drugs produce marked changes in body temperature. Recent findings have extended our knowledge about the thermoregulatory effects of cannabinoids and opioids, particularly as related to delta opioid receptors, endogenous systems, and transient receptor potential (TRP) channels. Although delta opioid receptors were originally thought to play only a minor role in thermoregulation compared to mu and kappa opioid receptors, their activation has been shown to produce hypothermia in multiple species. Endogenous opioids and cannabinoids also regulate body temperature. Mu and kappa opioid receptors are thought to be in tonic balance, with mu and kappa receptor activation producing hyperthermia and hypothermia, respectively. Endocannabinoids participate in the febrile response, but more studies are needed to determine if a cannabinoid CB1 receptor tone exerts control over basal body temperature. A particularly intense research focus is TRP channels, where TRPV1 channel activation produces hypothermia whereas TRPA1 and TRPM8 channel activation causes hyperthermia. The marked hyperthermia produced by TRPV1 channel antagonists suggests these warm channels tonically control body temperature. A better understanding of the roles of cannabinoid, opioid, and TRP systems in thermoregulation may have broad clinical implications and provide insights into interactions among neurotransmitter systems involved in thermoregulation.

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Section: Opioid Effects On Body Temperaturementioning

confidence: 94%