Role of Adjuvant Radiotherapy for Stage II Thymoma After Complete Tumor Resection

Chen, Yidong; Feng, Qinfu; Lu, Haizhen; Mao, Yousheng; Zhou, Zongmei; Ou, Guangfei; Wang, Mei; Zhao, Jun; Zhang, Hongxing; Xiao, Zefen; Chen, Dong-Fu; Liang, Jun; Zhai, Yirui; Wang, Lühua; He, Jie

doi:10.1016/j.ijrobp.2009.09.066

Cited by 49 publications

(44 citation statements)

References 25 publications

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“…When complete resection alone was compared with incomplete resection with PORT, complete resection was found to have superior outcomes. 13,23,24 Song et al 33 found with statistical significance in univariate analysis that extent of resection influenced the 5-year DFS and OS, with those who had resection faring better than those who did not. Weksler et al, 12 in their SEER-based review, found some interesting but conflicting findings to the trend of complete resection and better survival.…”

Section: Masaoka Stage and Extent Of Resectionmentioning

confidence: 99%

“…50 Gy for macroscopic is what some considered adequate. 9,24,37-39 Chen et al, 13 however, found no difference in outcome between higher or lower RT doses. Nonetheless, they recommended doses of 50 Gy as being adequate.…”

Section: Radiotherapy Dosementioning

confidence: 99%

“…8,10,13 This was especially pronounced in studies in which complete excision of the tumor was achieved. Because of the retrospective design and associated bias toward the cohort of patients selected for PORT, these findings should be carefully considered.…”

Section: Studies That Dispute the Use Of Portmentioning

confidence: 99%

“…However, some investigators recommend that postoperative RT (PORT) can be considered for various indications [8][9][10][11][12] and others do not find the use of PORT beneficial. [13][14][15][16][17][18] Where there is R1 or R2 resection PORT is sometimes recommended and with the latter, chemotherapy administration might even be considered. The dose of RT has been stipulated by some as 45 to 50 Gy for clear or close margins, 54 Gy for microscopically positive resection, and 60 Gy for gross residual disease.…”

Section: Introductionmentioning

confidence: 99%

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A Review of the Place and Role of Radiotherapy in Thymoma

Lombe

Jeremić

2015

Clinical Lung Cancer

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Section: Masaoka Stage and Extent Of Resectionmentioning

confidence: 99%

Section: Radiotherapy Dosementioning

confidence: 99%

Section: Studies That Dispute the Use Of Portmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Review of the Place and Role of Radiotherapy in Thymoma

Lombe

Jeremić

2015

Clinical Lung Cancer

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“…In a Japanese series of 324 patients with resected thymic tumour, 119 of whom had received post-operative radiotherapy, specific survival was lower after radiotherapy in case of type A-AB-B1 tumour, while no survival difference was observed in case of type B2-B3 tumours, independently from tumour stage [65]. In another series of 107 patients with resected stage II tumours, type B3 histology was an independent unfavourable prognostic factor, suggesting the potential interest for radiotherapy in this subset of patients [66]. Data for thymic carcinoma are hard to interpret given the rarity and inconsistency in the diagnostic criteria.…”

Section: Radiotherapy Principlesmentioning

confidence: 93%

Thymic epithelial tumours: from basic principles to individualised treatment strategies

Girard¹

2013

European Respiratory Review

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Thymic epithelial tumours represent a wide range of anatomical, clinical, histological and molecular malignant entities that may be aggressive and difficult to treat. The histopathological classification distinguishes thymomas from thymic carcinomas. Thymomas may be associated with autoimmune disorders.The management of thymic epithelial tumours is a paradigm of co-operation between clinicians, surgeons and pathologists, from establishing the diagnosis to organising the multimodal therapeutic strategy. Surgery is the mainstay of the curative-intent treatment, as complete resection represents the most significantly favourable prognostic factor on overall survival. In case of invasion of intra-thoracic structures and/or dissemination to the pleura and the pericardium, precluding complete resection to be achieved, primary chemotherapy has been used to reduce the tumour burden, possibly allowing subsequent surgery and/or radiotherapy.Novel strategies are needed, especially for refractory, recurrent tumours and thymic carcinomas, which carry a poor prognosis. Personalised approaches are currently being developed, as potentially ''druggable'' molecular targets are emerging from recent integrated genomic analyses. Along with the large variety of questions relative to the treatment strategy, thymic epithelial tumours represent a model of therapeutic implementation and achievement in orphan thoracic oncology, showing how the advent of new results induces new questions, as well as diversifies further clinical research directions and international collaborative initiatives.

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Postoperative radiotherapy: Not all thymic malignancies are created equal

Rimner

2015

Cancer

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Role of Adjuvant Radiotherapy for Stage II Thymoma After Complete Tumor Resection

Cited by 49 publications

References 25 publications

A Review of the Place and Role of Radiotherapy in Thymoma

A Review of the Place and Role of Radiotherapy in Thymoma

Thymic epithelial tumours: from basic principles to individualised treatment strategies

Postoperative radiotherapy: Not all thymic malignancies are created equal

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