Role of Adjuvant Multimodality Therapy After Curative-Intent Resection of Ampullary Carcinoma

Ecker, Brett L.; Vollmer, Charles M.; Behrman, Stephen W.; Allegrini, Valentina; Aversa, John; Ball, Chad G.; Barrows, Courtney E.; Berger, Adam C.; Cagigas, Martha N.; Christein, John D.; Dixon, Elijah; Fisher, William E.; Freedman-Weiss, Mollie; Guzmán-Pruneda, Francisco A.; Hollis, Robert H.; House, Michael G.; Kent, Tara S.; Kowalsky, Stacy J.; Malleo, Giuseppe; Salem, Ronald R.; Salvia, Roberto; Schmidt, Carl; Seykora, Thomas; Zheng, Richard; Zureikat, Amer H.; Dickson, Paxton V.

doi:10.1001/jamasurg.2019.1170

Cited by 57 publications

(44 citation statements)

References 31 publications

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“…The survival of patients with ampullary cancer ranges from 30 to 50% 2,3,37 . Adjuvant chemotherapy for high-risk patients is not associated with improved survival 38 . 5-Fluorouracil-based chemotherapy has some benefit to improve survival, but the results are unsatisfactory 39 .…”

Section: Discussionmentioning

confidence: 98%

Increased expression of secreted frizzled related protein 1 (SFRP1) predicts ampullary adenocarcinoma recurrence

Chao

Overman

et al. 2020

Sci Rep

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Ampullary adenocarcinoma is a rare gastrointestinal cancer in which WNT signalling dysregulation has been previously reported. Secreted frizzled related protein 1 (SFRP1) is one of the extracellular ligands of WNT signalling. We performed bioinformatics analyses of SFRP1 expression in human cancer. Microarray analysis of SFRP1 in periampullary adenocarcinoma was obtained from the Gene Expression Omnibus GSE39409 dataset. SFRP1 expression in ampullary adenocarcinoma was detected by immunohistochemistry staining and correlated with patients' clinical outcomes. Our results showed that SFRP1 expression had different clinical applications in all types of human cancer. no detected alteration of SFPR1 gene and SFRP1 expression in ampullary adenocarcinoma was lower than that in other periampullary adenocarcinomas. However, high expression levels of SFRP1 protein were correlated with cancer recurrence, peritoneal carcinomatosis and poor patient prognosis. Gene set enrichment analysis showed downregulation of multiple WNT-related genes in primary culture cells from ampullary adenocarcinoma, but SFRP1 expression was increased. We found an interaction between WNT, bone morphogenetic protein and hedgehog signalling with SFRP1. Furthermore, a high expression of SFRP1 predicted poor prognosis for ampullary adenocarcinoma patients. Because it is a multifunctional protein, SFRP1 targeting serves as a potential therapy for ampullary adenocarcinoma patients.

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Section: Discussionmentioning

confidence: 98%

Increased expression of secreted frizzled related protein 1 (SFRP1) predicts ampullary adenocarcinoma recurrence

Chao

Overman

et al. 2020

Sci Rep

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“…11,12 Radical resection is the standard treatment for ampullary cancer; however, adjuvant chemotherapy is ineffective. 13 Therefore, alternative treatment modalities should be developed. Studies have reported TGF-α expression, 14,15 downstream genetic mutation of TGFB1 and SMAD4, 16 and TGF-β signaling dysregulation in ampullary cancer.…”

Section: Introductionmentioning

confidence: 99%

<p>Cancer-Derived Transforming Growth Factor-β Modulates Tumor-Associated Macrophages in Ampullary Cancer</p>

Li¹,

Chao

Wang³

et al. 2020

OTT

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Tumor-associated macrophages (TAMs) originate from monocytes and differentiate into mature macrophages. The interaction between cancer cells and TAMs promotes tumor growth and suppresses immunosurveillance. However, this phenomenon has seldom been observed in ampullary cancer. Patients and Methods: TAMs in ampullary cancer were investigated using immunohistochemical (IHC) staining of cancer tissues. Bioinformatic analysis of data from the Gene Expression Omnibus (GEO) database revealed transforming growth factor-beta (TGF-β) signaling in ampullary cancer. The complementary DNA microarray of cancer was compared with adjacent normal duodenum and enzyme-linked immunosorbent assay of serum was used to verify TGF-β signaling in patients. The THP-1 cell line was activated in vitro to imitate M2 TAMs. ClueGo and CluePedia software were operated to simulate TGF-β-related networks in ampullary cancer. Results: The IHC study revealed that the majority of TAMs inside ampullary cancer were cluster of differentiation (CD)163 + cells and that the expression of mature CD68 + macrophages was correlated with advanced cancer stage. Bioinformatics analysis revealed that TGF-β and its downstream signaling were significantly upregulated. To verify our bioinformatics-derived predictions, we performed several experiments and demonstrated that increased TGF-β expression was detected in the cDNA microarray. Higher serum levels of TGF-β were correlated with fewer CD68 + and more inducible nitric oxide synthase macrophages in ampullary cancer. Treatment with TGF-β induced modulation of THP-1-derived macrophages. Conclusion: The present study demonstrates that TGF-β modulates macrophage activity in ampullary cancer. Targeting TGF-β could be an approach to activating immunosurveillance.

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“…17 -Gap between the crystals. Two mirror-displayed crystal (15) connected to the contact so that between them an air gap (17) of a width comparable with the wavelength of the incident radiation, is placed in a container filled with active substance (16), and exposed to coherent monochromatic light (1), and each face of one of the crystals is exposed to infrared (2), visible (3) and UV (4) ranges. Irradiation of each face is necessary due to the fact that the crystal has anisotropy and its physical properties in different directions are not identical.…”

Section: A Brief Review Of the Content Of The Technological Process Omentioning

confidence: 99%

“…With the subsequent step of pulsed laser radiation, even more complex structures (plastic deformations (14)) are formed in the crystal, carrying information about the physical properties of the active substance (16). These structures are holograms inside the crystal, carrying complete information about the physical, chemical, biological and other properties of the active substance (16), which do not depend on the aggregate state of the substance (16). In addition, after the laser breakdown, with the appearance of a shock wave, the sum of collective processes and the formation of defects increase avalanche-like.…”

Section: Figure 1 Technology Of Registration Information About the Pmentioning

confidence: 99%

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This study is determined a level of correlation within nine traits, variation, coefficient of determination and similarity of martixes in hairy vetch (Vicia villosa Roth) under control and salinity condition. It was found that a potential index of traits in salinity decreased by 5-17% compared to non-saline soil. The weight of the bean, the number of seed per bean and its weight were strongly determined and varied. Also, a similarity of the correlation matrixes shows as 91.6%. Our results suggests, a hairy vetch is a tolerant to salinity.

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Role of Adjuvant Multimodality Therapy After Curative-Intent Resection of Ampullary Carcinoma

Abstract: We thank the surgeons and research assistants who contributed patients and data from the following institutions constituting the Ampullary Carcinoma Study Group and Pancreas Fistula Study Group:

Cited by 57 publications

References 31 publications

Increased expression of secreted frizzled related protein 1 (SFRP1) predicts ampullary adenocarcinoma recurrence

Increased expression of secreted frizzled related protein 1 (SFRP1) predicts ampullary adenocarcinoma recurrence

<p>Cancer-Derived Transforming Growth Factor-β Modulates Tumor-Associated Macrophages in Ampullary Cancer</p>

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