Role of Adipose Derived Mesenchymal Stem Cells in Improving Streptozotocin-Induced Diabetes Mellitus in Rats

Effects of Insulin and Resveratrol Versus Mesenchymal Stem Cells (MSCs) on the pancreas of Diabetic Rats (Type-I) (Light and Electron Microscope Study)

“…Pancreatic acini appeared normal. These results were in consistent with (18) who explained this improvement by MSCs by their immunomodulatory properties and differentiation of MSC into insulinsecreting cells. Also, the results agreed by (19) , who showed that MSCs administration reduce the hyperglycemia and are accompanied by increased isletneogenesis.…”

“…GIIb showed a significant increase in Mean of the diameter of the islet when compared with GIIa. These results were consistent with (18,29,30) and there was a significant decrease in FBG level, area % of caspase 3, and collagen fibers as compared with GIIa this agreed by (5,31,32) who explained that pancreatic fibrosis may be caused by pancreatic stellate cells that have been activated by hyperglycemia, resulting in fibrotic changes. Group IIc had a significant increase in the mean diameter of islets and a significant decrease change in FBG level, collagen fibers, and caspase 3 immune reactivity as compared with GIIa and GIIb.…”

“…(24,25) revealed that STZ-induced hyperglycemia could initiate pancreatic βcells apoptosis in diabetic rats, through elevating apoptotic factors like annexin, and caspases-3,8,9 associated with decreased anti-apoptotic Bcl-2 expression. Also, those results were supported by the results of (18,26,27) who showed that controlling the blood glucose level by insulin treatment can promote beta-cell regeneration and decrease the apoptosis. The immunohistochemical results were in agreement with (27,28) who published that resveratrol coupling with ADSC showed a protective effect on pancreatic damage through the increased sirtuin 1 expression and suppression of caspase-3.…”