Role of adiponectin in regulating ovarian theca and granulosa cell function

Lagaly, Dana V.; Aad, Pauline Y.; Grado-Ahuir, Juan Alberto; Hulsey, Laura B.; Spicer, L. J.

doi:10.1016/j.mce.2008.01.007

Cited by 172 publications

(179 citation statements)

References 40 publications

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“…Furthermore, after pregnant mare serum gonadotropin (PMSG) pre-treatment, an injection of human chorionic gonadotropin (hCG) increases the expression of adiponectin and AdipoR1 (but not AdipoR2) genes in rat ovaries (Chabrolle et al 2007). Also, in bovine theca interna cells, LH increases the concentrations of AdipoR2 mRNAs, whereas insulin-like growth factor type 1 (IGF1) suppresses the expression of AdipoR2 (Lagaly et al 2008). Steroids could also affect adiponectin expression.…”

Section: Adiponectin Adipors and Resistin Expression In The Ovarymentioning

confidence: 99%

Adiponectin and resistin: potential metabolic signals affecting hypothalamo-pituitary gonadal axis in females and males of different species

Rak¹,

Mellouk²,

Froment³

et al. 2017

Reproduction

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Adipokines, including adiponectin and resistin, are cytokines produced mainly by the adipose tissue. They play a significant role in metabolic functions that regulate the insulin sensitivity and inflammation. Alterations in adiponectin and resistin plasma levels, or their expression in metabolic and gonadal tissues, are observed in some metabolic pathologies, such as obesity. Several studies have shown that these two hormones and the receptors for adiponectin, AdipoR1 and AdipoR2 are present in various reproductive tissues in both sexes of different species. Thus, these adipokines could be metabolic signals that partially explain infertility related to obesity, such as polycystic ovary syndrome (PCOS). Species and gender differences in plasma levels, tissue or cell distribution and hormonal regulation have been reported for resistin and adiponectin. Furthermore, until now, it has been unclear whether adiponectin and resistin act directly or indirectly on the hypothalamo-pituitary-gonadal axis. The objective of this review was to summarise the latest findings and particularly the species and gender differences of adiponectin and resistin on female and male reproduction known to date, based on the hypothalamo-pituitary-gonadal axis.Reproduction (2017) 153 R215-R226

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Section: Adiponectin Adipors and Resistin Expression In The Ovarymentioning

confidence: 99%

Adiponectin and resistin: potential metabolic signals affecting hypothalamo-pituitary gonadal axis in females and males of different species

Rak¹,

Mellouk²,

Froment³

et al. 2017

Reproduction

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“…Adiponectin had an inhibitory effect on in vitro secretion of progesterone by porcine luteal cells on days 10 to 12 of the estrous cycle (Maleszka et al 2014a). The effect of adiponectin on ovarian basal progesterone secretion was also suggested in studies on cows, rats, and humans (Chabrolle et al 2009;Mailard et al 2010;Lagaly et al 2008). Moreover, the insulin-induced production of progesterone and estradiol by bovine granulosa cells was significantly decreased as a result of adiponectin treatment (Mailard et al 2010).…”

Section: Discussionmentioning

confidence: 87%

“…Moreover, the insulin-induced production of progesterone and estradiol by bovine granulosa cells was significantly decreased as a result of adiponectin treatment (Mailard et al 2010). In the study with bovine theca interna cells, Lagaly et al (2008) observed that adiponectin decreased LH and insulin-induced production of progesterone. In this study, we observed changes in the expression of genes which may be involved in the regulation of steroid hormone secretion under adiponectin's influence.…”

Section: Discussionmentioning

confidence: 97%

The influence of adiponectin on the transcriptomic profile of porcine luteal cells

Szeszko

Smolińska

Kieżun

et al. 2015

Funct Integr Genomics

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Reproductive functions are closely related to nutritional status. Recent studies suggest that adiponectin may be a hormonal link between them. Adiponectin is an adipocytokine, abundantly expressed in adipose tissues. It plays a dominant role in lipid and carbohydrate metabolism by stimulating fatty acid oxidation, decreasing plasma triglycerides, and increasing cells' sensitivity to insulin and has direct antiatherosclerotic effects. The hormone is also postulated to play a modulatory role in the regulation of the reproductive system. The aim of this study was to identify differentially expressed genes (DE-genes) in response to adiponectin treatment of porcine luteal ovarian cells. The global expression of genes in the porcine ovary was investigated using the Porcine (V2) Two-color gene expression microarray, 4 × 44 (Agilent, USA). Analysis of the microarray data showed that 701 genes were differentially expressed and 389 genes showed a fold change greater than 1.2 (p < 0.05). Among this number, 186 genes were up-regulated and 203 were down-regulated. The list of DE-genes was used for gene ontology analyses. The biological process list was generated from up-regulated and down-regulated DE-genes. We found that up-regulated products of DE-genes take part in 30 biological processes and down-regulated products in 9. Analysis of the interaction network among DE-genes showed that adiponectin interacts with genes involved in important processes in luteal cells. These results provide a basis for future work describing the detailed interactions and relationships explaining local regulation of adiponectin actions in the ovary of pigs.

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“…In our laboratory, we have shown that adiponectin decreased insulin-induced steroidogenesis and increased IGF-I-induced proliferation of the bovine granulosa cells in culture possibly by a mechanism that involved the ERK1/2 MAPK pathway (Maillard et al, 2010). Lagaly et al (2008), have also observed an inhibitory effect of adiponectin on bovine steroidogenesis but only in the theca cells. Concerning the oocyte and embryo, we have shown that adiponectin did not modify either oocyte maturation or embryo development in vitro in bovine species.…”

Section: Metabolic Hormonesmentioning

confidence: 82%

The effect of nutrition and metabolic status on the development of follicles, oocytes and embryos in ruminants

Dupont

Scaramuzzi

Reverchon

2014

animal

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The impact of nutrition and energy reserves on the fertility of ruminants has been extensively described. However, the metabolic factors and the molecular mechanisms involved in the interactions between nutrition and ovarian function are still poorly understood. These factors could be hormonal (either reproductive and/or metabolic) and/or dietary and metabolic (glucose, amino acids and fatty acids). In this review, we briefly summarize the impact of those nutrients (fatty acids, glucose and amino acids) and metabolic hormones (insulin/IGF-I, growth hormone, T3/4, ghrelin, apelin and the adipokines (leptin, adiponectin and resistin)) implicated in the development of ovarian follicles, oocytes and embryos in ruminants. We then discuss the current hypotheses on the mechanisms of action of these factors on ovarian function. We particularly describe the role of some energy sensors including adenosine monophosphate-activated kinase and peroxisome proliferator-activated receptors in the ovarian cells.

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Role of adiponectin in regulating ovarian theca and granulosa cell function

Cited by 172 publications

References 40 publications

Adiponectin and resistin: potential metabolic signals affecting hypothalamo-pituitary gonadal axis in females and males of different species

Adiponectin and resistin: potential metabolic signals affecting hypothalamo-pituitary gonadal axis in females and males of different species

The influence of adiponectin on the transcriptomic profile of porcine luteal cells

The effect of nutrition and metabolic status on the development of follicles, oocytes and embryos in ruminants

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