Role of Adipokines and Perivascular Adipose Tissue in Abdominal Aortic Aneurysm: A Systematic Review and Meta-Analysis of Animal and Human Observational Studies

Thanigaimani, Shivshankar; Golledge, Jonathan

doi:10.3389/fendo.2021.618434

Cited by 10 publications

(7 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These changes were accompanied by a decrease in the accumulation of macrophages, a decrease in the expression of pro-inflammatory cytokines as well as MMP-2 and MMP-9 in the aortic wall [34]. Clinical studies revealed that plasma leptin and resistin concentration as well as greater amounts of PVAT were significantly higher in people with AAA compared to healthy counterparts [20].…”

Section: Obesity As a Risk Factor Of Aaamentioning

confidence: 98%

“…Obesity-related inflammation is associated with increased macrophage infiltration, increased cytokine expression in adipose tissue and increased angiotensin II levels, which may contribute to AAA formation [19]. Since aneurysms are an inflammatory disease, therefore, PVAT is of particular interest as it is perivascular adipose tissue, and the adipocytokines released from it may play a direct role in aortic pathology [6,20]. It has been shown that the amount of PVAT is higher in the aortas of AAA patients than in the control group [6,21].…”

Section: Obesity As a Risk Factor Of Aaamentioning

confidence: 99%

See 1 more Smart Citation

The Role of Obesity, Inflammation and Sphingolipids in the Development of an Abdominal Aortic Aneurysm

2022

View full text Add to dashboard Cite

Abdominal aortic aneurysm (AAA) is a local dilatation of the vessel equal to or exceeding 3 cm. It is a disease with a long preclinical period commonly without any symptoms in its initial stage. Undiagnosed for years, aneurysm often leads to death due to vessel rupture. The basis of AAA pathogenesis is inflammation, which is often associated with the excess of adipose tissue, especially perivascular adipose tissue, which synthesizes adipocytokines that exert a significant influence on the formation of aneurysms. Pro-inflammatory cytokines such as resistin, leptin, and TNFα have been shown to induce changes leading to the formation of aneurysms, while adiponectin is the only known compound that is secreted by adipose tissue and limits the development of aneurysms. However, in obesity, adiponectin levels decline. Moreover, inflammation is associated with an increase in the amount of macrophages infiltrating adipose tissue, which are the source of matrix metalloproteinases (MMP) involved in the degradation of the extracellular matrix, which are an important factor in the formation of aneurysms. In addition, an excess of body fat is associated with altered sphingolipid metabolism. It has been shown that among sphingolipids, there are compounds that play an opposite role in the cell: ceramide is a pro-apoptotic compound that mediates the development of inflammation, while sphingosine-1-phosphate exerts pro-proliferative and anti-inflammatory effects. It has been shown that the increase in the level of ceramide is associated with a decrease in the concentration of adiponectin, an increase in the concentration of TNFα, MMP-9 and reactive oxygen species (which contribute to the apoptosis of vascular smooth muscle cell). The available data indicate a potential relationship between obesity, inflammation and disturbed sphingolipid metabolism with the formation of aneurysms; therefore, the aim of this study was to systematize the current knowledge on the role of these factors in the pathogenesis of abdominal aortic aneurysm.

show abstract

Section: Obesity As a Risk Factor Of Aaamentioning

confidence: 98%

Section: Obesity As a Risk Factor Of Aaamentioning

confidence: 99%

The Role of Obesity, Inflammation and Sphingolipids in the Development of an Abdominal Aortic Aneurysm

2022

View full text Add to dashboard Cite

show abstract

“…Interestingly, experimental AAA models have shown that adiponectin infusion reduces vascular inflammation, prevents vascular infiltration of macrophage and attenuates AAA development ( 82 , 83 ). A recent systematic review and meta-analysis of animal and human observational studies, concluded that, although leptin and adiponectin upregulation do not affect AAA in animal models, studies in humans showed that resistin and leptin serum levels together with the amount of PVAT were higher in patients with AAA compared to control ( 84 ).…”

Section: Aaa and Dmmentioning

confidence: 99%

Protection of diabetes in aortic abdominal aneurysm: Are antidiabetics the real effectors?

Picatoste

Cerro-Pardo

Blanco-Colio

et al. 2023

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Aortic aneurysms, including abdominal aortic aneurysms (AAAs), is the second most prevalent aortic disease and represents an important cause of death worldwide. AAA is a permanent dilation of the aorta on its infrarenal portion, pathologically associated with oxidative stress, proteolysis, vascular smooth muscle cell loss, immune-inflammation, and extracellular matrix remodeling and degradation. Most epidemiological studies have shown a potential protective role of diabetes mellitus (DM) on the prevalence and incidence of AAA. The effect of DM on AAA might be explained mainly by two factors: hyperglycemia [or other DM-related factors such as insulin resistance (IR)] and/or by the effect of prescribed DM drugs, which may have a direct or indirect effect on the formation and progression of AAAs. However, recent studies further support that the protective role of DM in AAA may be attributable to antidiabetic therapies (i.e.: metformin or SGLT-2 inhibitors). This review summarizes current literature on the relationship between DM and the incidence, progression, and rupture of AAAs, and discusses the potential cellular and molecular pathways that may be involved in its vascular effects. Besides, we provide a summary of current antidiabetic therapies which use could be beneficial for AAA.

show abstract

“…A metaanalysis including 10 animal experiments and 8 human studies showed that AAA is correlated with a high concentration of plasma adipokines. Although several studies have examined the relationship between adipokines and AAA, this relationship remains poorly understood (Thanigaimani and Golledge, 2021). We need conduct more basic experiments to explore the role of PVAT in AAA formation and progression.…”

Section: Introductionmentioning

confidence: 99%

Identification of a biomarker and immune infiltration in perivascular adipose tissue of abdominal aortic aneurysm

Wang

Deng

et al. 2022

Front. Physiol.

View full text Add to dashboard Cite

Objective: Abdominal aortic aneurysm (AAA) refers to unusual permanent dilation of the abdominal aorta, and gradual AAA expansion can lead to fatal rupture. However, we lack clear understanding of the pathogenesis of this disease. The effect of perivascular adipose tissue (PVAT) on vascular functional status has attracted increasing attention. Here, we try to identify the potential mechanisms linking AAA and PVAT.Methods: We downloaded dataset GSE119717, including 30 dilated AAA PVAT samples and 30 non-dilated aorta PVAT samples from AAA cases, from Gene Expression Omnibus to identify differentially expressed genes (DEGs). We performed pathway enrichment analysis by Metascape, ClueGo and DAVID to annotate PVAT functional status according to the DEGs. A protein-protein interaction network, the support vector machine (SVM)-recursive feature elimination and the least absolute shrinkage and selection operator regression model were constructed to identify feature genes. Immune infiltration analysis was explored by CIBERSORT. And the correlation between feature gene and immune cells was also calculated. Finally, we used the angiotensin II (Ang II)-ApoE−/− mouse model of AAA to verify the effect of feature gene expression by confirming protein expression using immunohistochemistry and western blot.Results: We identified 22 DEGs, including 21 upregulated genes and 1 downregulated gene. The DEGs were mainly enriched in neutrophil chemotaxis and IL-17 signaling pathway. FOS was identified as a good diagnostic feature gene (AUC = 0.964). Immune infiltration analysis showed a higher level of T cells follicular helper, activated NK cells, Monocytes, activated Mast cells in AAA group. And FOS was correlated with immune cells. Immunohistochemistry and western blot confirmed higher FOS expression in PVAT of the AAA mouse model compared to control group. Conclusion:The differentially expressed genes and pathways identified in this study provide further understanding of how PVAT affects AAA development. FOS was

show abstract

Role of Adipokines and Perivascular Adipose Tissue in Abdominal Aortic Aneurysm: A Systematic Review and Meta-Analysis of Animal and Human Observational Studies

Cited by 10 publications

References 40 publications

The Role of Obesity, Inflammation and Sphingolipids in the Development of an Abdominal Aortic Aneurysm

The Role of Obesity, Inflammation and Sphingolipids in the Development of an Abdominal Aortic Aneurysm

Protection of diabetes in aortic abdominal aneurysm: Are antidiabetics the real effectors?

Identification of a biomarker and immune infiltration in perivascular adipose tissue of abdominal aortic aneurysm

Contact Info

Product

Resources

About