Role of adipokines and inflammatory markers in postmenopausal hypertension

July, Mose; Faiz, Saba; Yaqub, Abid; Santhanam, Prasanna; Douglas, Jillian; Stanek, Ronald J.; Gress, Todd; Olajide, Omolola; Driscoll, Henry K.; Santanam, Nalini

doi:10.23736/s0391-1977.17.02595-0

Cited by 6 publications

(9 citation statements)

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“…In the literature, many studies reported that TNF-α was increased in diabetes and postmenopausal period (5,22,23). Doganay et al reported that TNF-α and IL-6 levels were higher in diabetic individuals, who developed retinopathy, compared with patients without complications, and there was no significant difference between patients without complications and healthy individuals (24).…”

Section: Discussionmentioning

confidence: 99%

“…Endothelial tissue dysfunction is related to the imbalance of vasoconstrictor and vasodilator molecules secreted by the endothelium. Endothelin-1 (ET-1) is the strongest vasoconstrictor molecule functioning in the provision of molecule exchange order of endothelial tissue (5). Endothelium-derived synthesised nitric oxide (NO) takes functions in vascular tone regulation, leukocyte adhesion, aggregation of thrombocytes, and proliferation of vascular smooth muscles.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of endothelial dysfunction and inflammation in type 2 diabetic postmenopausal women

Abbak

Abbak²,

Bahtiyar

et al. 2023

Med Sci Discov

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Objective: Vascular complications in type 2 diabetes mellitus are an important cause of morbidity and mortality. Also, endothelial dysfunction arises with vascular ageing during the postmenopausal period. Our objective in this study was to evaluate inflammation and endothelial function parameters and their possible diagnostic roles in type 2 diabetic postmenopausal patients. Material and Methods: The study was conducted on four groups, including type 2 diabetic premenopausal (n:20), non-diabetic premenopausal (n:20), type 2 diabetic postmenopausal (n:20), and non-diabetic postmenopausal subjects (n:20). Serum endothelin-1 (ET-1), endothelial nitric oxide synthetase (eNOS), interleukin-6 (IL-6), tumor necrosis factor α (TNF-α), and chitinase-3-like protein 1 (YKL-40) levels were determined as inflammatory and endothelial function markers using ELISA kits. Results: Serum ET-1, IL-6, and YKL-40 levels were higher in the type 2 diabetic postmenopausal group compared to the non-diabetic premenopausal group (p<0.01, p<0.05, and p<0.01, respectively). ET-1, IL-6, and YKL-40 levels were higher in the type 2 diabetic postmenopausal group compared to the non-diabetic postmenopausal group (p<0.001, p<0.05, and p<0.01 respectively). ROC analysis revealed serum ET-1 (AUC 0.933, sensitivity 87.5%, specificity 85.7%), IL-6 (AUC 0.812, sensitivity 56.3%, specificity 92.8%), and YKL-40 (AUC 0.880, sensitivity 81.2%, specificity 92.8%), as good diagnostic parameters, especially in the type 2 diabetic premenopausal vs. non-diabetic premenopausal cohorts. Conclusion: Serum ET-1, IL-6, and YKL-40 levels were at the highest levels in the 2 diabetic postmenopausal group, and the increase in these markers was remarkable in diabetes compared with menopausal periods. Also, ET-1, IL-6, and YKL-40 were good diagnostic parameters for detecting endothelial function and inflammation in type 2 diabetic postmenopausal and non-diabetic premenopausal cohorts.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of endothelial dysfunction and inflammation in type 2 diabetic postmenopausal women

Abbak

Abbak²,

Bahtiyar

et al. 2023

Med Sci Discov

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“…While previous research has shown some evidence of such associations, this study found no association between blood levels of adiponectin and leptin or COMT genotype with blood pressure measures in women who were post-menopause. (9,16,(19)(20)(21)(22)34) Mechanistically, adiponectin plays a role in endothelial function, nitric oxide production and supports the action of antiinflammatory macrophages which ultimately may affect blood pressure. (15,16) A 5-year, prospective study including both men and women identified an inverse relationship between adiponectin and risk of hypertension; however, exploring these associations in women specifically is important as gender differences, with women usually having higher levels, have been reported.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the results of the current study are consistent with previous research suggesting there is no association with either SBP or DBP values or blood pressure status (normotensive v. hypertensive) in this population. (19)(20)(21)(22) Leptin is another fat-derived hormone of particular interest in this study. Its primary role in the body is to be a messenger to the brain regarding available energy stores; however, leptin may also impact blood pressure status due to its effect on sympathetic nervous system activation at the renal level.…”

Section: Discussionmentioning

confidence: 99%

“…(13,(16)(17)(18) For example, the majority of research that has specifically explored the relationship between adiponectin and blood pressure in women who are post-menopause does not support the reported findings of an inverse relationship. (16,(19)(20)(21)(22)(23) Similar to adiponectin, leptin is an adipokine that may also impact blood pressure status due to its effect on sympathetic nervous system activation at the renal level. (14,(24)(25)(26)(27)(28) Many studies have demonstrated a positive correlation between leptin and blood pressure.…”

Section: Introductionmentioning

confidence: 99%

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Exploration of plasma adiponectin, leptin, and COMT genotype on blood pressure among women who are post-menopause

Green,

Byham-Gray,

Kurzer

et al. 2023

J Nutr Sci

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Research suggests that adiponectin, leptin, and genetic polymorphisms such as catechol-O-methyltransferase (COMT) genotype may play an integral role in blood pressure status and thereby cardiovascular health. This is an area especially important for women who are post-menopause; however, the current literature investigating these associations is limited. This study was a cross-sectional secondary analysis of baseline data (N 237) from the Minnesota Green Tea Trial (MGTT). The current study explored the relationships between plasma adiponectin, leptin, and COMT genotype on blood pressure measures. Plasma adiponectin and leptin were obtained after an overnight fast of at least 10 h and were measured by the radioimmunoassay method. The relationships were analysed using multiple linear regression after adjusting for potential confounders. Effect modifications by age, body mass index (BMI) category, blood pressure category, antihypertensive medication use, and COMT genotype were also investigated. The majority of participants were non-Hispanic (97⋅9 %) and Caucasian (94⋅9 %). Mean (sd) age and BMI were 60⋅7 (5⋅0) years and 28⋅2 (2⋅9) kg/m2, respectively. After adjustment for confounding variables, neither plasma adiponectin, plasma leptin nor COMT genotype was associated with systolic or diastolic blood pressure measures. The results of stratified analyses also did not reveal any significant interactions or associations. Based on the findings of this study, which utilised more rigorous statistical methods than previous research, neither adiponectin, leptin nor COMT genotype play a role in blood pressure measures in women who are post-menopause.

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Inflammation, depression and cardiovascular disease in women: the role of the immune system across critical reproductive events

Mattina

Lieshout

Steiner

2019

Therapeutic Advances in Cardiovascular Disease

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Women are at increased risk for developing depression and cardiovascular disease (CVD) across the lifespan and their comorbidity is associated with adverse outcomes that contribute significantly to rates of morbidity and mortality in women worldwide. Immunesystem activity has been implicated in the etiology of both depression and CVD, but it is unclear how inflammation contributes to sex differences in this comorbidity. This narrative review provides an updated synthesis of research examining the association of inflammation with depression and CVD, and their comorbidity in women. Recent research provides evidence of pro-inflammatory states and sex differences associated with alterations in the hypothalamic-pituitary-adrenal axis, the renin-angiotensin-aldosterone system and the serotonin/kynurenine pathway, that likely contribute to the development of depression and CVD. Changes to inflammatory cytokines in relation to reproductive periods of hormonal fluctuation (i.e. the menstrual cycle, perinatal period and menopause) are highlighted and provide a greater understanding of the unique vulnerability women experience in developing both depressed mood and adverse cardiovascular events. Inflammatory biomarkers hold substantial promise when combined with a patient's reproductive and mental health history to aid in the prediction, identification and treatment of the women most at risk for CVD and depression. However, more research is needed to improve our understanding of the mechanisms underlying inflammation in relation to their comorbidity, and how these findings can be translated to improve women's health.

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Role of adipokines and inflammatory markers in postmenopausal hypertension

Cited by 6 publications

References 0 publications

Assessment of endothelial dysfunction and inflammation in type 2 diabetic postmenopausal women

Assessment of endothelial dysfunction and inflammation in type 2 diabetic postmenopausal women

Exploration of plasma adiponectin, leptin, and COMT genotype on blood pressure among women who are post-menopause

Inflammation, depression and cardiovascular disease in women: the role of the immune system across critical reproductive events

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