Role of adenosine receptors in the adipocyte–macrophage interaction during obesity

Meriño, Miguel; Briones, Lautaro; Palma, Verónica; Herlitz, Kurt; Escudero, Carlos

doi:10.1016/j.endien.2017.08.001

Cited by 10 publications

(9 citation statements)

References 67 publications

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“…All adenosine receptors were reported to be involved in glucose homeostasis, inflammation, adipogenesis, insulin resistance, and thermogenesis, indicating that adenosine participates in the process of obesity [56]. It was reported that the level of nucleoside adenosine is higher in individuals with obesity and that the specific activation of adenosine receptors could aid in the prevention of obesity [56,57]. Positively linked with the detrimental 3mop and negatively with met_L, adn also behaved as a negative metabolite in our study.…”

Section: Key Metabolites Associated With Obesity-relevant Clinical Parameterssupporting

confidence: 60%

Metagenome-Scale Metabolic Network Suggests Folate Produced by Bifidobacterium longum Might Contribute to High-Fiber-Diet-Induced Weight Loss in a Prader–Willi Syndrome Child

2021

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Gut-microbiota-targeted nutrition intervention has achieved success in the management of obesity, but its underlying mechanism still needs extended exploration. An obese Prader–Willi syndrome boy lost 25.8 kg after receiving a high-fiber dietary intervention for 105 days. The fecal microbiome sequencing data taken from the boy on intervention days 0, 15, 30, 45, 60, 75, and 105, along with clinical indexes, were used to construct a metagenome-scale metabolic network. Firstly, the abundances of the microbial strains were obtained by mapping the sequencing reads onto the assembly of gut organisms through use of reconstruction and analysis (AGORA) genomes. The nutritional components of the diet were obtained through the Virtual Metabolic Human database. Then, a community model was simulated using the Microbiome Modeling Toolbox. Finally, the significant Spearman correlations among the metabolites and the clinical indexes were screened and the strains that were producing these metabolites were identified. The high-fiber diet reduced the overall amount of metabolite secretions, but the secretions of folic acid derivatives by Bifidobacterium longum strains were increased and were significantly relevant to the observed weight loss. Reduced metabolites might also have directly contributed to the weight loss or indirectly contribute by enhancing leptin and decreasing adiponectin. Metagenome-scale metabolic network technology provides a cost-efficient solution for screening the functional microbial strains and metabolic pathways that are responding to nutrition therapy.

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Section: Key Metabolites Associated With Obesity-relevant Clinical Parameterssupporting

confidence: 60%

Metagenome-Scale Metabolic Network Suggests Folate Produced by Bifidobacterium longum Might Contribute to High-Fiber-Diet-Induced Weight Loss in a Prader–Willi Syndrome Child

2021

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“…We generated the expression profile of the entire set of non-visual GPCRs by using a high-throughput RT-PCR Array GPCR panel in mouse adipose tissue and differentiating adipocytes and re-analyzing RNA sequencing data of adipose tissue from healthy and obese human subjects. Many of the GPCRs with striking expression profiles have been comprehensively characterized for their adipose-specific functions and have attracted considerable attention in the drug discovery field (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). Chemokines and chemokine receptors have long been associated with obesity-linked inflammation and insulin resistance and modulation of the chemokine/Chemokine receptor axis is considered a novel approach for the treatment of obesity and associated metabolic disorders (31)(32).…”

Section: Discussionmentioning

confidence: 99%

“…Many GPCRs in this list have previously been studied for their role in adipose biology. These include alpha-and beta-adrenergic receptors (11)(12)(13)(14)(15)(16), adenosine receptors (19), free fatty acid receptors (7,17,18), adhesion receptors (20,21), hydroxycarboxylic acid receptors (22,23), gastric inhibitory peptide (27)(28)(29), chemokine receptors (30)(31) and many others (32)(33)(34)(35). Interestingly, many GPCRs with notable expression profiles in adipose tissue and adipocytes have no known role in adipose metabolism.…”

Section: Gpcrs Of Interestmentioning

confidence: 99%

“…βARs are also involved in thermogenesis in brown adipose tissue (15). In addition to the βARs, several other GPCRs have been shown to play important functional roles in white and brown fat including alpha-adrenergic receptors (16), free fatty acid receptors (7,17,18), adenosine receptors (19), adhesion receptors (20)(21), hydroxycarboxylic acid receptors (22,23), and many others (24). These still represent a significantly small fraction of the total number of GPCRs and the functional significance of a vast majority of GPCRs is not known in adipose metabolism.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Profiling of G-protein Coupled Receptors in Adipose Tissue and Differentiating Adipocytes Offers a Translational Resource for Obesity/Metabolic Research

Mahri¹,

Okla²,

Rashid³

et al. 2022

Preprint

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G protein-coupled receptors (GPCRs) are expressed essentially on all cells, facilitating cellular responses to external stimuli, and are involved in nearly every biological process. Several members of this family play significant roles in the regulation of adipogenesis and adipose me-tabolism. However, the expression and functional significance of a vast number of GPCRs in adipose tissue are unknown. We used a high-throughput RT-PCR panel to determine the expres-sion of the entire repertoire of non-sensory GPCRs in mouse white, and brown adipose tissue and assess changes in their expression during adipogenic differentiation of murine adipocyte cell line, 3T3-L1. In addition, the expression of GPCRs in subcutaneous adipose tissues from lean, obese, and diabetic human subjects was evaluated by re-analyzing RNA-sequencing data. We detected a total of 292 and 271 GPCRs in mouse white and brown adipose tissue, respectively. There is a significant overlap in the expression of GPCRs between the two adipose tissue depots but several GPCRs are specifically expressed in one of the two tissue types. Adipogenic differ-entiation of 3T3-L1 cells had a profound impact on the expression of several GPCRs. RNA se-quencing of subcutaneous adipose from healthy human subjects detected 255 GPCRs and obesity significantly changed the expression of several GPCRs in adipose tissue. Finally, we report sev-eral highly expressed GPCRs with no known role in adipose biology whose expression was sig-nificantly altered during adipogenic differentiation and/or in the diseased human subjects. These GPCRs could play an important role in adipose metabolism and serve as a valuable translational resource for obesity and metabolic research.

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“…Other A 1 R agonists, such as phenylisopropyladenosine, GR79236, and 2-chloroadenosine, exhibit anti-lipolytic effects following lipolysis induction in adipocytes from humans, rats, transgenic mice, and dogs (Hoffman et al 1984 ; Strong et al 1993 ; Johansson et al 2007 ; Tozzi and Novak 2017a ; Leiva et al 2017 ). GR79236 also promotes insulin sensitivity in adipose tissue through a reduction in circulating FFA and triglyceride levels (Meriño et al 2017 ). Simultaneously, A 1 R signaling promotes lipogenesis and modulates inflammation, shown by the absence of visceral adipose tissue (VAT) accumulation and proinflammatory cytokines (IL-1β, IL-6, IL-12, and TNF-α) in A 1 R knockout mice (Yang et al 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Regulatory roles of G-protein coupled receptors in adipose tissue metabolism and their therapeutic potential

Park

et al. 2021

Arch. Pharm. Res.

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The high incidence of obesity has increased the need to discover new therapeutic targets to combat obesity and obesity-related metabolic diseases. Obesity is defined as an abnormal accumulation of adipose tissue, which is one of the major metabolic organs that regulate energy homeostasis. However, there are currently no approved anti-obesity therapeutics that directly target adipose tissue metabolism. With recent advances in the understanding of adipose tissue biology, molecular mechanisms involved in brown adipose tissue expansion and metabolic activation have been investigated as potential therapeutic targets to increase energy expenditure. This review focuses on G-protein coupled receptors (GPCRs) as they are the most successful class of druggable targets in human diseases and have an important role in regulating adipose tissue metabolism. We summarize recent findings on the major GPCR classes that regulate thermogenesis and mitochondrial metabolism in adipose tissue. Improved understanding of GPCR signaling pathways that regulate these processes could facilitate the development of novel pharmacological approaches to treat obesity and related metabolic disorders.

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Role of adenosine receptors in the adipocyte–macrophage interaction during obesity

Cited by 10 publications

References 67 publications

Metagenome-Scale Metabolic Network Suggests Folate Produced by Bifidobacterium longum Might Contribute to High-Fiber-Diet-Induced Weight Loss in a Prader–Willi Syndrome Child

Metagenome-Scale Metabolic Network Suggests Folate Produced by Bifidobacterium longum Might Contribute to High-Fiber-Diet-Induced Weight Loss in a Prader–Willi Syndrome Child

Profiling of G-protein Coupled Receptors in Adipose Tissue and Differentiating Adipocytes Offers a Translational Resource for Obesity/Metabolic Research

Regulatory roles of G-protein coupled receptors in adipose tissue metabolism and their therapeutic potential

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