Role of ADAM and ADAMTS disintegrin and metalloproteinases in normal pregnancy and preeclampsia

Qu, Hongmei; Khalil, Raouf A.

doi:10.1016/j.bcp.2022.115266

Cited by 11 publications

(15 citation statements)

References 281 publications

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“…Previous research has shown that several ADAMTS proteins are expressed in human, mouse, and rat ovary, oviduct, placental and uterine tissues (Feng et al, 2021;Mani et al, 2019;Park et al, 2021;Qu & Khalil, 2022;Tatar et al, 2023).…”

Section: Discussionmentioning

confidence: 99%

“…PIGF‐ADAMTS‐8 expression was higher in tissue samples from the first trimester, while ADAMTS‐1 and ADAMTS‐4 were intensely expressed in tissue samples from the third trimester of pregnancy. Previous research has shown that several ADAMTS proteins are expressed in human, mouse, and rat ovary, oviduct, placental and uterine tissues (Feng et al, 2021; Mani et al, 2019; Park et al, 2021; Qu & Khalil, 2022; Tatar et al, 2023).…”

Section: Discussionmentioning

confidence: 99%

“…ADAMTS1 is also involved in angiogenesis and developing new blood vessels that provide nutrients for the endometrium. ADAMTS‐1 is thought to play a role in endometrial decidualization, trophoblast invasion and vascular formation during normal pregnancy (Qu & Khalil, 2022). ADAMTS‐1 must be expressed in specific endometrial regions for the initiation and maintenance of decidualization in vivo (Kalem et al, 2017; Ng et al, 2006; Takahashi et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Park et al described ADAMTS‐1 as a critical marker for embryo implantation in the mouse uterus during early pregnancy (Park et al, 2021). ADAMTS‐1 knockout mice exhibit decreased pregnancy rates, impaired implantation and reduced endometrium decidualization (Qu & Khalil, 2022). There is significant evidence showing that ADAMTS‐1 is essential for implantation and pregnancy, and it was observed at different levels in the maternal‐fetal tissue from the three different trimesters in this study.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Expression of placental growth factor and a disintegrin and metalloprotease with a thrombospondin type motifs 1‐4‐8 during the three trimesters of rat pregnancy at the maternal‐fetal interface

Tatar

Uslu

Öner

2023

Anat Histol Embryol

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The functional roles of the a disintegrin and metalloprotease with a thrombospondin type motifs (ADAMTS) gene family in reproductive physiology, reproductive organs developments and adult reproductive health are still under investigation. The expression of the anti‐angiogenic proteases ADAMTS‐1, ADAMTS‐4 and ADAMTS‐8 in placental angiogenesis at various stages of pregnancy also remains unclear. The purpose of this study was therefore to determine the localization and expression of the ADAMTS‐1, ADAMTS‐4 and ADAMTS‐8 proteins during the three stages of pregnancy in rats. Maternal‐fetal tissue samples were collected on Days 5, 12 and 19 of each trimester, corresponding to the first, second and third trimesters. The expression of placental growth factor (PlGF) and ADAMTS‐1, ADAMTS‐4 and ADAMTS‐8 at the maternal‐fetal interface was examined using immunohistochemistry and western blot at three distinct phases of pregnancy. ADAMTS‐1, ADAMTS‐4 and ADAMTS‐8 were detected in all three trimesters of pregnancy. The relative amount of PIGF increased in the first trimester and decreased significantly in the third trimester (p < 0.05). The expression of ADAMTS‐1 and ADAMTS‐4 was significantly higher in the second (p < 0.05) and third trimesters (p < 0.01) compared to the first trimester. However, no statistically significant change was observed in ADAMTS‐8 expression between trimesters. The ADAMTS exhibiting the highest expression during the first trimester was ADAMTS8. These findings indicate that the expression of ADAMTS‐1, ADAMTS‐4 and ADAMTS‐8 in the three different stages of rat pregnancy may be involved in the modulation of decidualization, morphogenesis and angiogenesis. Periodic changes in ADAMTS expression are thought to be regulated by gonadal steroids.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Expression of placental growth factor and a disintegrin and metalloprotease with a thrombospondin type motifs 1‐4‐8 during the three trimesters of rat pregnancy at the maternal‐fetal interface

Tatar

Uslu

Öner

2023

Anat Histol Embryol

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“…Pregnancy-induced hypertension (PIH) is one of the leading causes of maternal and perinatal morbidity and mortality [1] . Preeclampsia (PE) is a serious complication of pregnancy that was characterized by new-onset hypertension around the 20th gestational week (GW) with or without proteinuria [2] and may complicate up to 5% of pregnancies worldwide [3] . The risk of maternal and perinatal complications is considerably higher in cases had early-onset PE (EOPE) and/or severe PE (SPE) [4] .…”

Section: Introductionmentioning

confidence: 99%

The Relation between Deregulated Immune Milieu and Atherogenic Lipids Might Underlie the Development of Pregnancy-induced Hypertensive Disorders

Zaher

Rageh

Morsy

2023

Evidence Based Women's Health Journal

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Objectives: Evaluation of the relation between plasma lipoprotein(a) (LPA) and serum tumor necrosis factor-α (TNF-α) levels estimated in blood samples (S1 sample) obtained at the 6th gestational week (GW; T1 time) and the development of preeclampsia (PE) as judged by blood pressure measures at the time of diagnosis of PE (T2 time). Patients and Methods: 140 newly pregnant women gave S1 sample at T1 time; during pregnancy 19 women developed early-onset PE (EOPE) and 51 women developed late-onset PE (LOPE); 16 women developed severe PE (SPE) and 54 women developed mild PE (MPE), while 70 women were normotensive (NT) till the end of pregnancy. At T2 time, all patients gave S2 sample for ELISA estimation of plasma LPA and serum TNF-α level in both samples. Results: Serum TNF-α and plasma LPA levels were significantly higher in all S2 than S1 samples, in both samples of PE than NT women, and in both samples of women who developed EOPE and/or SPE than in samples of women who developed LOPE and/or MPE, respectively. Regression analysis of T1 data defined high body mass index; BMI (β=0.162, P=0.028), high S1 levels of TNF-α (β=0.424, P<0.001), and LPA (β=0.314, P<0.001) as predictors for development of PE as judged by SBP measures at T2 time. Correlation analysis showed a positive significant (P<0.001) correlation between at-T2-SBP measures with at-T1 BMI and S1 levels of TNF-α and LPA with a positive significant correlation between levels of both variables and with at-T1 BMI. Conclusion: High serum levels of TNF-α and plasma LPA levels early in pregnancy could predict the development of PE and its severity.

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The progression of obstructive renal fibrosis in rats is regulated by ADAMTS18 gene methylation in the embryonic kidney through the AKT/Notch pathway

Xu,

Zhang,

et al. 2023

J Biochem & Molecular Tox

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This study aimed to explore the mechanism by which postembryonic renal ADAMTS18 methylation influences obstructive renal fibrosis in rats. After exposure to transforming growth factor (TGF)‐β1 during the embryonic period, analysis of postembryonic renal ADAMTS18 methylation and expression levels was conducted. Histological analysis was performed to assess embryonic kidney lesions and damage. Western blot analysis was used to determine the expression of renal fibrosis markers. Rats with ureteral obstruction and a healthy control group were selected. The methylation levels of ADAMTS18 in the different groups were analyzed. Western blot analysis and immunohistochemistry were performed to analyze the expression of renal fibrosis markers, and kidney‐related indicators were measured. Treatment with TGF‐β1 resulted in abnormal development of the postembryonic kidney, which was characterized by rough kidney surfaces with mild depressions and irregularities on the outer surface. TGF‐β1 treatment significantly promoted ADAMTS18 methylation and activated the protein kinase B (AKT)/Notch pathway. Ureteral obstruction was induced to establish a renal hydronephrosis model, which led to renal fibrotic injury in newborn rats. Overexpression of the ADAMTS18 gene alleviated renal fibrosis. The western blot results showed that compared to that in the control group, the expression of renal fibrosis markers was significantly decreased after ADAMTS18 overexpression, and there was a thicker renal parenchymal tissue layer and significantly reduced p‐AKT/AKT and Notch1 levels. TGF‐β1 can induce ADAMTS18 gene methylation in the postembryonic kidney, and the resulting downregulation of ADAMTS18 expression has long‐term effects on kidney development, potentially leading to increased susceptibility to obstructive renal fibrosis. This mechanism may involve activation of the AKT/Notch pathway. Reversing ADAMTS18 gene methylation may reverse this process.

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Role of ADAM and ADAMTS disintegrin and metalloproteinases in normal pregnancy and preeclampsia

Cited by 11 publications

References 281 publications

Expression of placental growth factor and a disintegrin and metalloprotease with a thrombospondin type motifs 1‐4‐8 during the three trimesters of rat pregnancy at the maternal‐fetal interface

Expression of placental growth factor and a disintegrin and metalloprotease with a thrombospondin type motifs 1‐4‐8 during the three trimesters of rat pregnancy at the maternal‐fetal interface

The Relation between Deregulated Immune Milieu and Atherogenic Lipids Might Underlie the Development of Pregnancy-induced Hypertensive Disorders

The progression of obstructive renal fibrosis in rats is regulated by ADAMTS18 gene methylation in the embryonic kidney through the AKT/Notch pathway

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