Role of acetylcholinesterase in lung cancer

Abstract

Acetylcholinesterase (AChE) plays a key role in catalytic hydrolysis of cholinergic neurotransmitters. Intensive research has proven the involvement of this protein in novel functions, such as cell adhesion, differentiation, and proliferation. In addition, several recent studies have indicated that acetylcholinesterase is potentially a marker and regulator of apoptosis. Importantly, AChE is also a promising tumor suppressor. In this review, we briefly summarize the involvement of AChE in apoptosis and cancer, focusing on the role of AChE in lung cancer, as well as the therapeutic consideration of AChE for cancer therapy.

Biological evaluation of the toxicity and the cell cycle interruption by some benzimidazole derivatives

“…The tested compounds were designed as inhibitors of topoisomerase I [13]. From literature, it is known that camptothecin and other inhibitors of topoisomerase I also tend to result in the inhibition of AChE [20, 21]. Using them can cause the cholinergic syndrome, usually mild, although this is one of the main reasons for cancelling such drugs from the treatment in the anticancer therapy.…”

“…Furthermore, abnormal expression and structural alteration of AChE and multiple activities have been found in different types of tumors, such as brain, lung, ovarian, breast, hepatocellular, renal, and colon cancers, which indicate the involvement of AChE in regulating the tumor development. However, the role of AChE in tumor progression remains unclear [19, 20, 21]. …”

Studying the Enzymes Levels in Cerebrospinal Fluid for Children With Acute Lymphoblastic Leukemia

“…[6] AChE is a novel regulator in cell proliferation and cell death, allowing AChE as a potential marker for cancer diagnosis and prognosis. [22] AChE gene expression is always decreased in tumor tissues, and AChE has been reported to suppress cell proliferation via catalytic hydrolysis of acetylcholine, So acts as a tumor growth suppressor.…”

“…It has also been demonstrated that AChE can hydrolyze lipid peroxides and that may support the possibility of the reduction in enzyme activity augments oxidative stress and cellular damage. [6] The effect of estrogen on the brain and its stimulation to pull of choline and further build the acetylcholine, may be the reason for the higher activity of enzyme in male than female.…”

“…[6] The monoamine oxidases (MAOs) are mitochondrial bound isoenzymes which catalyze the oxidative deamination of monoamine neurotransmitters, including 5-hydroxytryptamine, histamine and catecholamines (Dopamine, noradrenaline and adrenaline). MAO is classified into two types (A and B), according to their sensitivity towards specificity substrates and inhibitors.…”