Role of Acetylcholine in the Activity of Sensori-Motor and Suppressor Areas of the Cortex

Beckett, S; Gellhorn, E.

doi:10.1152/ajplegacy.1948.153.1.113

Cited by 16 publications

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“…The finding of a direct parallelism between the release of ACh from the primary sensory cortex and the amplitude of the evoked response during stimulation of the peripheral nerve at different frequencies, and the fact that these surface potentials are altered by ACh and prostigmine applied topically to the cortex or injected into the cerebral circulation (Chatfield & Dempsey, 1942;Beckett & Gellhorn, 1948;Bremer & Chatonnet, 1949;Marrazzi & Hart, 1950;Chatfield & Purpura, 1954) might suggest that a proportion of the ACh released from the cortex is derived from the structures responsible for the generation of these potentials. Yet it is more likely that the association between ACh release and the magnitude of the evoked potentials is a reflexion of a progressive reduction in afferent activity reaching the cortex as the frequency of peripheral stimulation increases.…”

mentioning

confidence: 99%

The spontaneous and evoked release of acetylcholine from the cerebral cortex

Mitchell¹

1963

The Journal of Physiology

382

122

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mentioning

confidence: 99%

The spontaneous and evoked release of acetylcholine from the cerebral cortex

Mitchell¹

1963

The Journal of Physiology

382

122

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Interaction of Effects of Acetylcholine and Adenosine Triphosphate on Electrical Activity of Cat Cerebral Cortex

Jordan¹,

Badal²,

March³

1950

Arch NeurPsych

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AND RUTH MARCH, M.T.(ASCP) SEATTLE IN THE course of an investigation into effects on the electrical activity of the cat cerebral cortex exerted by substances known to be present in nerve tissue, we have studied the interaction between acetylcholine and adenosine triphosphate after their successive local application to the cortex. We consider the findings suggestive enough to justify a separate description. Our attention was directed to the investigation of this interaction by the demonstration of Nachmansohn 1 that adenosine triphosphate plays a role in the synthesis of acetylcholine by nerve tissue, under certain conditions, in vitro. METHODThe results of experiments on 22 mongrel adult cats are reported here. Anesthesia was induced by the intraperitoneal injection of pentobarbital sodium, U. S. P., in a dose of 0.060 Gm. (1 grain) per kilogram of body weight. If, during a long experiment, the need arose for further anesthesia, an intraperitoneal injection of about 0.016 Gm. of pentobarbital sodium was given. The cerebral cortex was exposed widely, usually on the left side, occasionally bilaterally. Absorbent cotton wool wick electrodes were employed, each soaked in 0.9 per cent sodium chloride solution and wrapped around silver wire soldered to a shielded copper wire, which, in turn, was led to a model III four channel Grass electroencephalograph, for amplification and recording of the potential changes.

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Biochemical and physiological differentiation during morphogenesis. XV. Acetylcholinesterase activity of the motor cortex of the fetal guinea pig

Kavaler¹,

Kimel²

1952

J of Comparative Neurology

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Role of Acetylcholine in the Activity of Sensori-Motor and Suppressor Areas of the Cortex

Cited by 16 publications

References 0 publications

The spontaneous and evoked release of acetylcholine from the cerebral cortex

The spontaneous and evoked release of acetylcholine from the cerebral cortex

Interaction of Effects of Acetylcholine and Adenosine Triphosphate on Electrical Activity of Cat Cerebral Cortex

Biochemical and physiological differentiation during morphogenesis. XV. Acetylcholinesterase activity of the motor cortex of the fetal guinea pig

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