2021
DOI: 10.1016/j.neuron.2020.10.012
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Role of Aberrant Spontaneous Neurotransmission in SNAP25-Associated Encephalopathies

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Cited by 40 publications
(54 citation statements)
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“…Previous studies have shown that munc18‐1 overexpression alone does not alter miniature endplate potential amplitudes at the neuromuscular junction and causes an increase in the RRP size of cultured hippocampal neurons which would be predicted to blunt synaptic depression, an effect opposite to our results (Toonen et al., 2006). Similarly, hippocampal neurons with a 50% reduction in SNAP‐25 expression have no changes in mEPSC amplitudes or frequencies and exhibit an increase in PPR, suggesting a decrease in release probability, which also contrasts with our results (Alten et al., 2021).…”
Section: Discussioncontrasting
confidence: 99%
“…Previous studies have shown that munc18‐1 overexpression alone does not alter miniature endplate potential amplitudes at the neuromuscular junction and causes an increase in the RRP size of cultured hippocampal neurons which would be predicted to blunt synaptic depression, an effect opposite to our results (Toonen et al., 2006). Similarly, hippocampal neurons with a 50% reduction in SNAP‐25 expression have no changes in mEPSC amplitudes or frequencies and exhibit an increase in PPR, suggesting a decrease in release probability, which also contrasts with our results (Alten et al., 2021).…”
Section: Discussioncontrasting
confidence: 99%
“…However recent evidence suggests that spontaneous release has a specialized role in both regulating synapse and circuit development in addition to the maintenance of synapse dynamics in several organisms ( Huntwork and Littleton, 2007 ; Choi et al, 2014 ; Andreae and Burrone, 2015 ; Banerjee et al, 2021 ). Furthermore recent findings on the role of aberrant spontaneous neurotransmission in neurological disease as well as ketamine’s rapid antidepressant action arising from spontaneous release modulation reflect the utility of different modes of release at the synapse ( Autry et al, 2011 ; Alten et al, 2021 ). Ultimately revealing spontaneous neurotransmission as an autonomous mode of release involved in a broad range of functions ( Kavalali and Monteggia, 2020 ).…”
Section: Spontaneous Releasementioning
confidence: 99%
“…Moreover, spontaneous release can activate distinct downstream signaling pathways compared to evoked release (Horvath et al, 2021). Spontaneous release has also been implicated in mechanisms underlying neuropsychiatric and neurological diseases as well as their treatments separate from evoked release (Alten et al, 2021; Autry et al, 2011; Kavalali and Monteggia, 2012).…”
Section: Introductionmentioning
confidence: 99%