Role of ABCA1 on membrane cholesterol content, insulin-dependent Akt phosphorylation and glucose uptake in adult skeletal muscle fibers from mice

Sánchez-Aguilera, Pablo; Díaz-Vegas, Alexis; Campos, Cristián; Quinteros-Waltemath, Oscar; Cerda-Kohler, Hugo; Barrientos, Genaro; Contreras‐Ferrat, Ariel; Llanos, Paola

doi:10.1016/j.bbalip.2018.09.005

Cited by 27 publications

(27 citation statements)

References 47 publications

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“…A recent study showed that some effects of ABC transporters on signal transduction might be imparted by their influence on cholesterol transport for raft formation (Fig 2C ). One example is that reduction of ABCA1 through in vivo electro-poration with shABCA1-RFP plasmid in mice resulted in cholesterol efflux defect and the subsequent increase in the membrane cholesterol content [136]. Increased membrane cholesterol reduces phosphoinositide-dependent kinase (or Akt) phosphorylation at Ser-473, insulin-induced GLUT4 translocation in the plasma membrane, and glucose uptake in skeletal muscles [136].…”

Section: Abc Transporters and Cellular Signallingmentioning

confidence: 99%

“…One example is that reduction of ABCA1 through in vivo electro-poration with shABCA1-RFP plasmid in mice resulted in cholesterol efflux defect and the subsequent increase in the membrane cholesterol content [136]. Increased membrane cholesterol reduces phosphoinositide-dependent kinase (or Akt) phosphorylation at Ser-473, insulin-induced GLUT4 translocation in the plasma membrane, and glucose uptake in skeletal muscles [136]. Similarly, an abnormal status of ABCA1 is observed in insulin resistance [137].…”

Section: Abc Transporters and Cellular Signallingmentioning

confidence: 99%

“…Additionally, phosphatidylserine (PS) is translocated through ABCG1 from the inner to the outer leaflet of the PM serving as an apoptotic marker and resulting in cell death [110]. Conversely, a decrease or defect in ABC transporters may lead to membrane cholesterol accumulation, increasing lipid rafts formations [136,[143][144][145][146]. This recruits TREM-1 and TLR4 into the raft, leading to their activation, ERK1/2 phosphorylation, inflammasome activation, and pro-inflammatory cytokines secretion [145].…”

Section: Abc Transporters and Cellular Signallingmentioning

confidence: 99%

“…This recruits TREM-1 and TLR4 into the raft, leading to their activation, ERK1/2 phosphorylation, inflammasome activation, and pro-inflammatory cytokines secretion [145]. Increased lipid rafts further reduce PI3K/Akt phosphorylation, insulin-induced GLUT4 translocation in the PM, and glucose uptake in skeletal muscles [136]. Direct pathway (solid arrows); Indirect pathway (dashed arrows).…”

Section: Abc Transporters and Cellular Signallingmentioning

confidence: 99%

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Transporters Beam Signals from Cell Membranes

Ristovski¹,

Farhat²,

Bancud³

et al. 2021

Preprint

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Lipid composition in the cellular membranes plays an important role in maintaining the struc-tural integrity of cells and in regulating cellular signaling that controls functions of both mem-brane-anchored and cytoplasmic proteins. ATP-dependent ABC and P4-ATPase lipid transport-ers, two integral membrane proteins, are known to contribute to lipid translocation across the li-pid bilayers on the cellular membranes. In this review, we will highlight current knowledge about the role of cholesterol and phospholipids of cellular membrane in regulating cell signaling and how lipid transporters participate this process.

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Section: Abc Transporters and Cellular Signallingmentioning

confidence: 99%

Section: Abc Transporters and Cellular Signallingmentioning

confidence: 99%

Section: Abc Transporters and Cellular Signallingmentioning

confidence: 99%

Section: Abc Transporters and Cellular Signallingmentioning

confidence: 99%

See 2 more Smart Citations

Transporters Beam Signals from Cell Membranes

Ristovski¹,

Farhat²,

Bancud³

et al. 2021

Preprint

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“…Insulin resistance refers to the pathological state in which insulin promotes glucose uptake and decreased utilization e ciency caused by a variety of reasons, as the main glucose uptake tissue: skeletal muscle and fat play an important role in insulin resistance [13]. Insulin would stimulate AKT (protein kinase B) phosphorylation, phosphorylation-AKT lead to glucose uptake, when insulin resistance occurs, the phosphorylation of AKT was inhibited, the glucose uptake of each target tissue was signi cantly weakened, and the blood glucose concentration will be maintained at a high level [14,15].…”

mentioning

confidence: 99%

Study on the Therapeutic Effects of Traditional Chinese Medicine on Insulin Resistance in Obese Mice by Modulating Intestinal Function

Ma¹,

Bai²,

Wang³

et al. 2020

Preprint

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Background: Obesity, in particular with the excessive visceral fat distribution which accompanied by several alterations at hormonal, inflammatory and endothelial level, was great to the detriment to human health. Although there were many treatments for obesity, most of them fail to had a radical effect or were accompanied with several side effects. Traditional Chinese medicine (TCM) for regulating the intestinal flora, lipids, and inflammation were considered to be effective. Based on previous research, Artemisia capillaris, Astragalus propinquus, Phellodendron amurense, Salvia miltiorrhiza, Poria cocos, and Anemarrhena asphodeloides were eventually selected to form an innovative herbal formula.Methods: The anti-inflammatory and lipid-lowering effects of the TCM were evaluated in an obese mouse models fed with a high-fat diet, and the effects of the TCM on the intestinal flora were further investigated.Results: The weights and insulin resistant of mice, as well as the inflammation, decreased after treatment. At the same time, the lipid metabolism increased after the mice were gavage with the TCM formula for 2 weeks. The intestinal motility of mice in the drug administration group was enhanced, and the intestinal flora was partially restored.Conclusion: In summary, our innovative Chinese herbal formula could significantly reduce the weight of obese mice, reduce the intestinal inflammation, improve intestinal motility, and improve the lipid metabolism in mice. Furthermore, the innovative formular could effectively prevent relevant metastasis diseases induced by obesity in mice.

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Sphingolipids and Cholesterol

2022

Sphingolipid Metabolism and Metabolic Disease

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Role of ABCA1 on membrane cholesterol content, insulin-dependent Akt phosphorylation and glucose uptake in adult skeletal muscle fibers from mice

Cited by 27 publications

References 47 publications

Transporters Beam Signals from Cell Membranes

Transporters Beam Signals from Cell Membranes

Study on the Therapeutic Effects of Traditional Chinese Medicine on Insulin Resistance in Obese Mice by Modulating Intestinal Function

Sphingolipids and Cholesterol

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