Role of a mild reducing agent in designing a copper nanocluster-based tunable dual-metal sensor for the selective and sensitive detection of Ag+ and Fe2+

Sebastian, Anna; Aarya, None; Kavya, P; Mojumdar, Supratik Sen

doi:10.1016/j.chphi.2023.100249

Cited by 6 publications

(8 citation statements)

References 60 publications

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“…The synthesized lysozyme-capped copper nanocluster (Lys-Cu NC) showed excellent photoluminescence (PL) properties. When excited at 365 nm, the nanocluster showed a strong PL intensity centered around 437 nm with utmost stability . Upon comparison of the PL intensity of the nanocluster with the pure lysozyme exposed to the same reaction conditions, it is evident that the PL intensity is the inherent characteristic of the metal core and does not come from the protein scaffold when excited at 365 nm (Figure S1).…”

Section: Resultsmentioning

confidence: 97%

“…The lysozyme-protected copper nanocluster (Lys-Cu NC) and the tryptophan-capped copper nanocluster (Trp-Cu NC) were synthesized following a previously reported protocol. 20,43 4.4. Effect of Denaturant on the PL Properties of the NC and the Pure Protein Scaffold.…”

Section: Methodsmentioning

confidence: 99%

“…The circular dichroism (CD) spectra were measured by using a Jasco J-815 spectropolarimeter. The photoluminescence quantum yield (ϕ) of the prepared nanocluster was obtained using the method reported earlier …”

Section: Methodsmentioning

confidence: 99%

“…The photoluminescence quantum yield (ϕ) of the prepared nanocluster was obtained using the method reported earlier. 43 4.3. Synthesis of Photoluminescent Lys-Cu NC and Trp-Cu NC.…”

Section: Methodsmentioning

confidence: 99%

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Temperature-Induced Luminescence Intensity Fluctuation of Protein-Protected Copper Nanoclusters: Role of Scaffold Conformation vs Nonradiative Transition

Sebastian,

Aarya

et al. 2024

ACS Omega

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Protein-scaffolded atomically precise metal nanoclusters (NCs) have emerged as a promising class of biofriendly nanoprobes at the forefront of modern research, particularly in the area of sensing. The photoluminescence (PL) intensity of several nanoclusters showed a systematic temperature-dependent fluctuation, but the mechanism remains ambiguous and is poorly understood. We tried to shed some light on this mechanistic aspect by testing a couple of hypotheses: (i) conformational fluctuation of the protein scaffold-mediated PL intensity fluctuation and (ii) PL intensity fluctuation due to the variation in the radiative and nonradiative transition rates. Herein, the PL intensity of the lysozyme-capped copper nanocluster (Lys-Cu NC) showed excellent temperature dependency; upon increasing the temperature, the PL intensity gradually decreased. However, contrasting effects can be seen when the nanocluster is exposed to a chemical denaturant (guanidine hydrochloride (GdnHCl)); the PL intensity increased with the increase in the GdnHCl concentration due to the change in the ionic strength of the medium. This discrepancy clearly suggests that the thermal PL intensity fluctuation cannot be explained by a change in the scaffold conformation. Furthermore, upon closer investigation, we observed a 2-fold increase in the nonradiative decay rate of the Lys-Cu NC at the elevated temperature, which could reasonably explain the decrease in the PL intensity of the nanocluster at the higher temperature. Additionally, from the result, it was evident that the protein scaffold−metal core interaction played a key role here in stabilizing each other; hence, the scaffold structure remained unaffected even in the presence of chemical denaturants.

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Section: Resultsmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…The photoluminescence quantum yield (ϕ) of the prepared nanocluster was obtained using the method reported earlier. 43 4.3. Synthesis of Photoluminescent Lys-Cu NC and Trp-Cu NC.…”

Section: Methodsmentioning

confidence: 99%

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Temperature-Induced Luminescence Intensity Fluctuation of Protein-Protected Copper Nanoclusters: Role of Scaffold Conformation vs Nonradiative Transition

Sebastian,

Aarya

et al. 2024

ACS Omega

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“…For a calibration plot of current vs log concentration, it is difficult to determine the LOD. In our case, we have calculated the LOD by taking the concentration at which the current in μA is 3σ times greater than that of the blank buffer solution . The calculation for the same is detailed in SI.…”

Section: Resultsmentioning

confidence: 99%

MXene-Integrated Single-Stranded Carbon Yarn-Based Wearable Sensor Patch for On-Site Monitoring of Dopamine

Ankitha,

Shamsheera,

Rasheed

2024

ACS Appl. Electron. Mater.

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The demand for noninvasive wearable sensors for on-site monitoring has surged, particularly in the realm of personalized healthcare. This study introduces a pioneering approach employing a MXene-integrated single-stranded carbon yarn-based sensor patch utilizing a minimalist three-thread electrode setup for real-time monitoring of dopamine levels from artificial human sweat. The ability to immediately sew, weave, or stitch sensor platforms onto any type of clothing makes wearable thread-based sensor patches extremely promising, and it can be positioned in close proximity to the skin. Flexible conductive carbon yarn (CCY) was modified by Ti 3 C 2 T x MXene by a facile dip-coating method which was used as sensing electrodes. Leveraging MXene's high surface area and exceptional conductivity, the sensor's architecture achieved heightened sensitivity and selectivity in dopamine detection and reproducibility in a broad linear range of 1 nM−1 μM with a detection limit of 316 pM, along with real sample tests showing the promise of this platform for real-time physiological monitoring of human performance/fitness under stress as well as diagnostic monitoring through sweat analysis. The three-thread electrode configuration, strategically embedded within the patch, ensures ease of use and comfortable, noninvasive on-body application, offering a promising avenue for continuous, real-time monitoring of dopamine levels in individuals with neurological disorders or relevant medical conditions. This study highlights the potential of MXene-integrated wearable sensor patches with a minimalist electrode setup, advancing the field of wearable sensing technologies for personalized healthcare and point-of-care diagnostics.

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A review on copper-based nanoparticles as a catalyst: synthesis and applications in coupling reactions

Pathak,

Punetha,

Bhatt

et al. 2024

J Mater Sci

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Role of a mild reducing agent in designing a copper nanocluster-based tunable dual-metal sensor for the selective and sensitive detection of Ag+ and Fe2+

Cited by 6 publications

References 60 publications

Temperature-Induced Luminescence Intensity Fluctuation of Protein-Protected Copper Nanoclusters: Role of Scaffold Conformation vs Nonradiative Transition

Temperature-Induced Luminescence Intensity Fluctuation of Protein-Protected Copper Nanoclusters: Role of Scaffold Conformation vs Nonradiative Transition

MXene-Integrated Single-Stranded Carbon Yarn-Based Wearable Sensor Patch for On-Site Monitoring of Dopamine

A review on copper-based nanoparticles as a catalyst: synthesis and applications in coupling reactions

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