1994
DOI: 10.1126/science.7916164
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Role of a Conserved Retinoic Acid Response Element in Rhombomere Restriction of Hoxb-1

Abstract: After activation in mesoderm and neuroectoderm, expression of the Hoxb-1 gene is progressively restricted to rhombomere (r) 4 in the hindbrain. Analysis of the chick and mouse Hoxb-1 genes identified positive and negative regulatory regions that cooperate to mediate segment-restricted expression during rhombomere formation. An enhancer generates expression extending into r3 and r5, and a repressor limits this domain to r4. The repressor contains a conserved retinoic acid response element, point mutations in wh… Show more

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Cited by 263 publications
(172 citation statements)
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“…Fewer examples of position-dependent transcription because of negative regulation exist in mammals, but such regulation does occur. For example, position-dependent Hoxd-11 and Hoxb1 gene activation involves the interplay of positive and negative elements (24,25). The highly restricted position-dependent activity of EIII in the adult liver, in contrast to EIII activity in all hepatocytes in the fetal liver, led us to ask whether negative regulation led to this developmental change in EIII activity.…”
Section: Discussionmentioning
confidence: 99%
“…Fewer examples of position-dependent transcription because of negative regulation exist in mammals, but such regulation does occur. For example, position-dependent Hoxd-11 and Hoxb1 gene activation involves the interplay of positive and negative elements (24,25). The highly restricted position-dependent activity of EIII in the adult liver, in contrast to EIII activity in all hepatocytes in the fetal liver, led us to ask whether negative regulation led to this developmental change in EIII activity.…”
Section: Discussionmentioning
confidence: 99%
“…Our results suggest that if these RAREs respond to RA in vivo, they do so only within an established pattern of expression; there is no expansion of the expression domains of either gene in response to all-trans RA. Perhaps the retinoid responsiveness and basal expression of genes containing distinct RAREs are regulated by other mechanisms or factors in a complex tissue that is not available in a homogeneous cultured cell population (see also Studer et al, 1994). Such diversity in the regulation of retinoid responses would increase the range of potential consequences for retinoid signaling during regional and cellular differentiation.…”
Section: Rare-tk-p-gal Transgene Detects a Distinct Type Of Retinoid mentioning
confidence: 99%
“…RA directly regulates gene expression through its nuclear hormone receptor (RAR) and co-receptor (RXR), which bind RA response elements (RAREs) in the enhancers of target genes (Bastien and Rochette-Egly, 2004). In the hindbrain, RA regulates the expression of 3Ј-Hox genes through direct (in the case of Hox-1 and Hox-4 genes) or indirect (in the case of Hox-3 genes) mechanisms (Gould et al, 1998;Hernandez et al, 2004;Marshall et al, 1994;Nolte et al, 2003;Studer et al, 1994;Zhang et al, 2000). Other anterior RAresponsive genes (Hox-1 family genes) are expressed earlier and at lower RA concentrations than the more-posterior RA-responsive genes (Hox-4 family genes) (Dupe and Lumsden, 2001;Maves and Kimmel, 2005;Simeone et al, 1990).…”
Section: Introductionmentioning
confidence: 99%