Role of a 10-Gy boost in the conservative treatment of early breast cancer: results of a randomized clinical trial in Lyon, France.

Abstract

Delivery of a boost of 10 Gy to the tumor bed after 50 Gy to the whole breast following limited surgery significantly reduces the risk of early local recurrence, with no serious deterioration in the cosmetic result. Additional follow-up evaluation will be required to assess the long-term results.

Standard for Breast Conservation Therapy in the Management of Invasive Breast Carcinoma

“…Although controversy has existed concerning the need for delivering an additional boost dose to the primary site, [85][86][87] there is growing consensus about its utility. 87,88 Most recently, the EORTC has reported the favorable impact of boost on local failure rates.…”

“…87,88 Most recently, the EORTC has reported the favorable impact of boost on local failure rates. 88 Several considerations may be involved in the decision to use a boost: histological studies show that residual cancer following resection of the primary cancer usually is in the vicinity of the primary site; 89 recurrences following treatment usually are seen at or near the primary site; 90 and boost treatment can be delivered without significant morbidity.…”

A Systematic Overview of Radiation Therapy Effects in Breast Cancer

“…The role of radiation boost after breast conservation surgery has been addressed in two randomized studies (26,27). The impact of radiation therapy to IMC is investigated in a small randomized trial comparing breast conservation surgery plus radiotherapy plus inclusion of IMC in the target volume (28).…”

A importância da utilização de clips cirúrgicos na delimitação do volume de tratamento do reforço de dose no planejamento radioterápico

“…Nenhum estudo demonstrou benefício em sobrevida global com a adição do boost. Houve ganho estatisticamente significativo em sobrevida livre de recorrência local (Tabela 1) [14][15][16][17][18][19] . Romestaing et al randomizaram 1.024 pacientes com câncer de mama estádio inicial (<3 cm) tratados com cirurgia conservadora e radioterapia adjuvante de toda a mama com 50 Gy, em receber ou não boost de 10 Gy com elétrons no leito tumoral.…”