Role of 9p21 and 2q36 variants and arterial stiffness in the prediction of coronary artery disease

Vakalis, Konstantinos; Bechlioulis, Aris; Naka, Katerina K.; Chatzikyriakidou, Anthoula; Gartzonika, Konstantina; Vezyraki, Patra; Kolios, George; Παππάς, Κωνσταντίνος; Katsouras, Christos S.; Georgiou, Ioannis; Michalis, Lampros K.

doi:10.1111/eci.12295

Cited by 4 publications

(6 citation statements)

References 45 publications

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“…In aortic PWV studies, MI was often included in the definition of outcome variables such as overall CVD events or CHD, but not investigated as an individual outcome as has been done in this study. These previous studies show an association between aortic PWV and CHD,8, 31, 32, 33 as is shown here as well. Our results are consistent with previous PP studies that reported associations with both incident MI3 and CHD34 after adjustment for traditional CVD risk factors in a hypertensive and community‐based cohort, respectively.…”

Section: Discussionsupporting

confidence: 92%

Relationship of Arterial Stiffness Index and Pulse Pressure With Cardiovascular Disease and Mortality

Said

Eppinga

Lipšic

et al. 2018

JAHA

164

131

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BackgroundVascular aging results in stiffer arteries and may have a role in the development of cardiovascular disease (CVD). Arterial stiffness index (ASI), measured by finger photoplethysmography, and pulse pressure (PP) are 2 independent vascular aging indices. We investigated whether ASI or PP predict new‐onset CVD and mortality in a large community‐based population.Methods and ResultsWe studied 169 613 UK Biobank participants (mean age 56.8 years; 45.8% males) who underwent ASI measurement and blood pressure measurement for PP calculation. Mean±SD ASI was 9.30±3.1 m/s and mean±SD PP was 50.98±13.2 mm Hg. During a median disease follow‐up of 2.8 years (interquartile range 1.4–4.0), 18 190 participants developed CVD, of which 1587 myocardial infarction (MI), 4326 coronary heart disease, 1192 heart failure, and 1319 stroke. During a median mortality follow‐up of 6.1 years (interquartile range 5.8–6.3), 3678 participants died, of which 1180 of CVD. Higher ASI was associated with increased risk of overall CVD (unadjusted hazard ratio 1.27; 95% confidence interval [CI], 1.25–1.28), myocardial infarction (1.38; 95% CI, 1.32–1.44), coronary heart disease (1.31; 95% CI, 1.27–1.34), and heart failure (1.31; 95% CI 1.24–1.37). ASI also predicted mortality (all‐cause, CVD, other). Higher PP was associated with overall CVD (1.57; 95% CI, 1.55–1.59), myocardial infarction (1.48; 95% CI, 1.42–1.54), coronary heart disease (1.47; 95% CI, 1.43–1.50), heart failure (1.47; 95% CI, 1.40–1.55), and CVD mortality (1.47; 95% CI, 1.40–1.55). PP improved risk reclassification of CVD in a non–laboratory‐based Framingham Risk Score by 5.4%, ASI by 2.3%.Conclusions ASI and PP are independent predictors of CVD and mortality outcomes. Although both improved risk prediction for new‐onset disease, PP appears to have a larger clinical value than ASI.

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Section: Discussionsupporting

confidence: 92%

Relationship of Arterial Stiffness Index and Pulse Pressure With Cardiovascular Disease and Mortality

Said

Eppinga

Lipšic

et al. 2018

JAHA

164

131

View full text Add to dashboard Cite

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“…For the polymorphism within the ANRIL locus, carriers of at least one A allele were significantly more prevalent in the patients than in the controls (81.7 % vs 72.7 %; OR [95% CI] 1.67 [1.35-2.05]) (Table 2). This result is in agreement with a wide list of results published previously (Palomaki et al, 2010;Hubáček et al, 2012b;Vakalis et al, 2014;Kong et al, 2018), albeit on differentially defined patients. Interestingly, in a large multicentre study (Patel et al, 2019), the same polymorphism was not associated with increased cardiovascular mortality among patients with established congenital heart disease at baseline.…”

Section: Resultssupporting

confidence: 93%

Genetic Markers at ANRIL, FTO and 2q36.3 Locus in Czech Patients Undergoing Coronary Artery Bypass Graft Surgery

Kačer,

Pirk,

Lánská

et al. 2020

Fol. Biol.

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Coronary artery bypass graft (CABG) surgery is one of the most commonly performed operations worldwide. We compared genotype frequencies of three major cardiovascular disease (CVD)-associated genetic markers (ANRIL, FTO and 2q36.3 locus) between 753 patients who underwent CABG at the Institute for Clinical and Experimental Medicine (Prague, Czech Republic) and 2,559 controls from the Czech post-MONICA study. Subjects with at least one major A allele in the rs10757274 polymorphism (ANRIL) were more prevalent in patients after CABG than in the controls (81.7 % vs 72.7 %; OR [95 % CI] 1.67 [1.35-2.05]; P < 0.0001). In contrast, variants within the FTO gene (OR 0.87; 95% CI, 0.70-1. 09 in a TT vs. GG comparison, P = 0.24) and 2q36.3 locus (OR 1.16; 95% CI, 0.98-1.37 in a +A vs. CC comparison, P = 0.08) were not significantly associated with CVD in our study. Variants were not associated with anthropometric, biochemical, or clinical characteristics within the patient group. Our study suggests that patients with CABG are more commonly carriers of some but not all CVD-associated alleles.

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“…With regard to arterial stiffness, cfPWV was independently associated with CHD prevalence (but not AIx75). These findings are in agreement with previous studies [ 15 - 17 ]. However, a link between AIx75 and a composite endpoint of myocardial infarction, stroke, cardiac, cerebrovascular, and peripheral revascularization as well as total mortality has been reported in Austrian males (n = 520) undergoing coronary angiography [ 21 ].…”

Section: Discussionsupporting

confidence: 94%

“…Arterial stiffness (assessed by cfPWV) has been previously linked to the presence of coronary heart disease (CHD) [ 15 - 17 ]. Syntax score (SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery) may be used to evaluate CHD complexity, severity and clinical prognosis in various patient subgroups undergoing percutaneous coronary interventions (PCIs) [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Is There an Association Between Carotid-Femoral Pulse Wave Velocity and Coronary Heart Disease in Patients with Coronary Artery Disease: A Pilot Study

Katsiki¹,

Kollari²,

Dardas³

et al. 2016

TOCMJ

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Arterial stiffness has been shown to predict cardiovascular morbidity and mortality. Carotid-femoral pulse wave velocity (cfPWV) is regarded the gold standard marker of arterial stiffness. In previous studies, cfPWV was associated with the presence of coronary heart disease (CHD). However, with regard to CHD severity as assessed by the Syntax Score, only brachial-ankle PWV was reported to correlate with Syntax Score; no data exist for cfPWV.In this pilot study, we evaluated the possible associations between cfPWV, CHD and Syntax Score in 62 consecutive pa-tients (49 males; mean age: 64±12years) with chest pain undergoing scheduled coronary angiography. cfPWV was signifi-cantly higher in CHD patients than in non-CHD individuals (10 vs. 8.4 m/s; p = 0.003). No significant association was found between cfPWV and CHD severity as assessed by Syntax Score. A cut-off point of 12.3 m/s was considered as diagnostic for abnormally increased cfPWV (specificity: 97%; sensitivity: 12%; positive likelihood ratio: 3.558). Further research is needed to establish the relationship between cfPWV and Syntax Score.

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Role of 9p21 and 2q36 variants and arterial stiffness in the prediction of coronary artery disease

Cited by 4 publications

References 45 publications

Relationship of Arterial Stiffness Index and Pulse Pressure With Cardiovascular Disease and Mortality

Relationship of Arterial Stiffness Index and Pulse Pressure With Cardiovascular Disease and Mortality

Genetic Markers at ANRIL, FTO and 2q36.3 Locus in Czech Patients Undergoing Coronary Artery Bypass Graft Surgery

Is There an Association Between Carotid-Femoral Pulse Wave Velocity and Coronary Heart Disease in Patients with Coronary Artery Disease: A Pilot Study

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