Role of 99mTc-hexakis-2-methoxyisobutylisonitrile for detecting marrow metastases in childhood solid tumours

Berberoğlu, Kezban; Ünal, Sabri; Kebudi, Rejin; Türkmen, Cüneyt; Cantez, Sema

doi:10.1097/00006231-200512000-00005

Cited by 4 publications

(8 citation statements)

References 16 publications

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“…Concerning bone marrow metastases, the risk of bias in patient selection was low in 7 (50%) [29,32,34,40,[45][46][47] and unclear in 7 studies (50%) [25,27,38,[41][42][43][44]. The concerns regarding applicability were low in 9 (64%) [27,29,32,34,40,42,[45][46][47] and unclear in 5 (36%) [25,38,41,43,44]. In 2 of the 7 studies with an unclear risk of bias in patient selection, the applicability concerns were low [27,42] and in 5 unclear [25,38,41,43,44].…”

Section: Methodological Quality Of the Studies Evaluating The Diagnosmentioning

confidence: 99%

“…The concerns regarding applicability were low in 9 (64%) [27,29,32,34,40,42,[45][46][47] and unclear in 5 (36%) [25,38,41,43,44]. In 2 of the 7 studies with an unclear risk of bias in patient selection, the applicability concerns were low [27,42] and in 5 unclear [25,38,41,43,44]. SENS: Sensitivity; SPEC: Specificity; N: Number; B: Bone; BM: Bone marrow; MIBG: Metaiodobenzylguanidine; MRI: Magnetic Resonance Imaging; STIR: Short TI Inversion Recovery; gad-T1: Gadolinium-T1; 18 F-FDG-PET: Fluorine-18-fluorodeoxy-glucose Positron Emission Tomography; 99 mTc-MIBI: Technetium-99m-methylene Sestamibi (MIBI); 111 In-pentetreotide: Indium Pentetreotide; 201 T: Indium.…”

Section: Methodological Quality Of the Studies Evaluating The Diagnosmentioning

confidence: 99%

“…Of the 31 studies, 8 studies formulated a definition of bone metastases [8,[18][19][20][21][22][23][24], 13 of bone marrow metastases [25][26][27][28][29][30][31][32][33][34][35][36][37] and 10 defined both types of metastases [38][39][40][41][42][43][44][45][46][47] (Table 2). The included studies used different imaging methods to detect bone or bone marrow metastases (per study often more than one imaging method was used).…”

Section: Characteristics Of Included Studies Objective 1: Definitionsmentioning

confidence: 99%

“…The sensitivity and specificity for the detection of bone marrow metastases, on different imaging techniques and with different definitions, ranged from 0.26 to 1.00 in 11 studies [27,32,34,38,40,41,[43][44][45][46][47], and 0.41 to 1.00 for 12 studies [25,27,29,32,[40][41][42][43][44][45][46][47], respectively (Table 4A). For 18 F-FDG-PET scintigraphy, the sensitivity and specificity of the whole-body scans were shown.…”

Section: Diagnostic Accuracy For the Detection Of Bone Marrow Metastamentioning

confidence: 99%

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A Systematic Literature Review of Imaging Definitions for Detection of Bone and Bone Marrow Metastases in Neuroblastoma Patients

Bleeker¹,

Heijkoop²,

Dalen³

et al. 2015

J Bone Marrow Res

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Objective: The presence of bone and bone marrow (BM) metastases in neuroblastoma patients are independent adverse prognostic factors, so precise and consistent definitions of both categories on imaging are important. The objectives of this systematic review were to identify all definitions reported for detection of bone and bone marrow metastases on imaging in neuroblastoma to determine diagnostic accuracies of the most frequently used definitions for detection of bone and/or BM metastases on each imaging technique. Methods: We searched MEDLINE/PubMed (1945 to April 2013) and EMBASE/Ovid (1980 to April 2013). Full-text original studies were included if they reported definitions of bone and/or BM metastases on diagnostic imaging of children with suspected metastatic neuroblastoma. As reference standard for bone metastases bone scintigraphy was used and for bone marrow metastases bone marrow biopsies/aspirates. Methodological quality was assessed. Results: Of 403 identified studies (plus one relevant reference), 131 were assessed in full-text and 31 finally included, 23 described BM metastases and 18 bone metastases. No uniform definitions of bone and bone marrow metastases were reported for each imaging method. On MIBG scintigraphy bone metastases were mostly defined as "focal" and BM metastases as "diffuse" and on MRI both definitions were used for BM metastases. The diagnostic accuracy of different diagnostic methods to detect bone (reference test bone scintigraphy) or BM (reference test bone marrow biopsies/ trephines) metastases varied widely. Conclusion: No uniform definitions of bone and bone marrow metastases were reported for each imaging method and concerning the diagnostic accuracy no general conclusions could be drawn.

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Section: Methodological Quality Of the Studies Evaluating The Diagnosmentioning

confidence: 99%

Section: Methodological Quality Of the Studies Evaluating The Diagnosmentioning

confidence: 99%

Section: Characteristics Of Included Studies Objective 1: Definitionsmentioning

confidence: 99%

Section: Diagnostic Accuracy For the Detection Of Bone Marrow Metastamentioning

confidence: 99%

See 2 more Smart Citations

A Systematic Literature Review of Imaging Definitions for Detection of Bone and Bone Marrow Metastases in Neuroblastoma Patients

Bleeker¹,

Heijkoop²,

Dalen³

et al. 2015

J Bone Marrow Res

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“…Recently, although fluorodeoxyglucose positron emission tomography (FDG PET) throws a light on this field, its wide application was limited by higher cost and area distribution [8][9][10][11][12][13][14][15][16][17]. 99 Tc m -sestamibi single photon emission computed tomography ( 99 Tc m -MIBI SPECT), a myocardial perfusion scintigraphic agent, is currently reportedly being used in tumor imaging [18][19][20][21][22][23][24][25][26][27][28]. The purpose of this prospective study was to investigate the efficacy and feasibility of 99 Tc m -MIBI SPECT in detecting the primary, residual, recurrent NPC tumors.…”

Section: Introductionmentioning

confidence: 99%

Technetium-99m-sestamibi SPECT for the diagnosis and follow-up of nasopharyngeal carcinoma

Chen

et al. 2010

Front. Med. China

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This study was to investigate a better way to detect and differentiate primary, residual, recurrent nasopharyngeal carcinoma (NPC) lesions post-radiotherapy in patients with NPC by means of routine computed tomography (CT) in combination with 99 Tc m -sestamibi single photon emission computed tomography ( 99 Tc m -MIBI SPECT). Forty-eight patients with histologically confirmed primary NPC underwent 99 Tc m -MIBI SPECT at the 3rd month before and after radiotherapy, and at the 6th month after radiotherapy. All patients had contemporaneous CT examinations. Histopathologic results and/or clinical follow-up data (over 18 months) were used as the golden standard for evaluating residual/recurrent lesions. The radioactive count ratio of nasopharynx to scalp was obtained as the MIBI uptake index (MUI). Receiver operating characteristic analysis was employed to define the cut-off value of MUI for malignancy. With MUI 2.15 as the cut-off point, the accuracy for detecting primary NPC was 94.12%. The mean MUI in the local-regional of the nasopharynx in such negative cases was 1.21AE 0.12 at the 3rd month, while the mean MUI was higher in the other 15 patients with histologically confirmed recurrent/residual lesions (MUI = 1.40 AE 0.16, t = 4.71, P < 0.001). The optimal cut-off point of 1.33 of MUI was defined with 89.58% accuracy for differentiating residual/recurrent lesions from the benign process post radiotherapy, while CT evaluations showed an accuracy of 81.25%. A combination of CT and 99 Tc m -MIBI SPECT for 37 NPC patients with congruent results showed an accuracy of 97.30% for differentiating residual/recurrent NPC from benign lesions. 99 Tc m -MIBI SPECT plays a role in evaluating residual/recurrent lesions post-radiotherapy. The combination of CT and 99 Tc m -MIBI SPECT can give more accurate diagnosis in the follow-up of NPC.

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Roles of PET/Computed Tomography in the Evaluation of Neuroblastoma

2020

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Role of 99mTc-hexakis-2-methoxyisobutylisonitrile for detecting marrow metastases in childhood solid tumours

Abstract: Abnormal 99mTc-MIBI uptake correlated extremely well with bone marrow aspiration/biopsy cytology results. Non-invasive 99mTc-MIBI imaging in children with malignant solid tumours appears to be promising for the evaluation of bone marrow metastases.

Cited by 4 publications

References 16 publications

A Systematic Literature Review of Imaging Definitions for Detection of Bone and Bone Marrow Metastases in Neuroblastoma Patients

A Systematic Literature Review of Imaging Definitions for Detection of Bone and Bone Marrow Metastases in Neuroblastoma Patients

Technetium-99m-sestamibi SPECT for the diagnosis and follow-up of nasopharyngeal carcinoma

Roles of PET/Computed Tomography in the Evaluation of Neuroblastoma

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