Role of 5-HT5A receptors in the consolidation of memory

González, Roberto; Chávez-Pascacio, Karla; Meneses, Alfredo

doi:10.1016/j.bbr.2013.05.051

Cited by 41 publications

(21 citation statements)

References 26 publications

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“…For example, SB-699551-A had no effect in the forced swim test, but induced sedation in rats (87), and, whereas increased cAMP has been linked to positive effects on memory consolidation (88), an impairment of this trait was reported by other investigators, in mice treated with the same 5HT5A antagonist (89). Furthermore, 5HT5A has been identified as an inhibitory autoreceptor that regulates the release of serotonin, if only in the absence of concurrent signaling through 5HT1A receptors (90).…”

Section: Discussionmentioning

confidence: 77%

Prion Protein Modulates Monoaminergic Systems and Depressive-like Behavior in Mice

Beckman

Santos

Americo

et al. 2015

Journal of Biological Chemistry

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Background:The prion protein (PrP C ) functions as a scaffold for cell surface signaling systems, and plays a role in neurodegenerative diseases that include clinical depression among their symptoms. Results: PrP C -null mice showed depressive-like behavior concomitant with functional changes in monoaminergic systems. Conclusion: PrP C regulates functions of monoaminergic synapses. Significance: PrP C may be involved in major depression and related neuropsychiatric disorders.

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Section: Discussionmentioning

confidence: 77%

Prion Protein Modulates Monoaminergic Systems and Depressive-like Behavior in Mice

Beckman

Santos

Americo

et al. 2015

Journal of Biological Chemistry

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“…Only 5-HT 5A has only been identified in human cortical layers and cerebellum (Pasqualetti et al, 1998). 5-HT 5A has been shown to couple to Gα i in HEK cells (Hurley et al, 1998), and the selective 5-HT 5A antagonist, SB-6995516, impairs memory (Gonzalez et al, 2013) and reduces acoustic startle (Curtin et al, 2013) in animal models. It has been suggested that the 5-HT 5 receptor may be a therapeutic target in psychiatric disorders (Thomas, 2006), but to date, no selective agonists for this subtype exist to clarify its role.…”

Section: Historic Aspects and Significancementioning

confidence: 99%

Structure and function of serotonin G protein-coupled receptors

McCorvy

Roth

2015

Pharmacology & Therapeutics

290

252

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Serotonin receptors are prevalent throughout the nervous system and the periphery, and remain one of the most lucrative and promising drug discovery targets for disorders ranging from migraine headaches to neuropsychiatric disorders such as schizophrenia and depression. There are 14 distinct serotonin receptors, of which 13 are G protein coupled receptors (GPCRs), which are targets for approximately 40% of the approved medicines. Recent crystallographic and biochemical evidence has provided a converging understanding of the basic structure and functional mechanics of GPCR activation. Currently, two GPCR crystal structures exist for the serotonin family, the 5-HT1B and 5-HT2B receptor, with the antimigraine and valvulopathic drug ergotamine bound. The first serotonin crystal structures not only provide the first evidence of serotonin receptor topography but also provide mechanistic explanations into functional selectivity or biased agonism. This review will detail the findings of these crystal structures from a molecular and mutagenesis perspective for driving rational drug design for novel therapeutics incorporating biased signaling.

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“…Animal studies also have found that a decrease in 5-HT reduced conditioned responses in both short and long-term memory (Gonzalez et al, 2013), while its availability improved the stabilization of emotional memories (Baratta et al, 2016), if preceded by a history of repeated stress exposure (Ohmura et al, 2015). …”

Section: The Role Of 5-ht Systems In the Allocentric Lockmentioning

confidence: 99%

Neurobiology of Anorexia Nervosa: Serotonin Dysfunctions Link Self-Starvation with Body Image Disturbances through an Impaired Body Memory

Riva

2016

Front. Hum. Neurosci.

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The etiology of anorexia nervosa (AN) is still unclear, despite that it is a critical and potentially mortal illness. A recent neurobiological model considers AN as the outcome of dysfunctions in the neuronal processes related to appetite and emotionality (Kaye et al., 2009, 2013). However, this model still is not able to answer a critical question: What is behind body image disturbances (BIDs) in AN? The article starts its analysis from reviewing some of the studies exploring the effects of the serotonin systems in memory (episodic, working, and spatial) and its dysfunctions. The review suggests that serotonin disturbances may: (a) facilitate the encoding of third person (allocentric) episodic memories; (b) facilitate the consolidation of emotional episodic memories (e.g., teasing), if preceded by repeated stress; (c) reduce voluntary inhibition of mnestic contents; (d) impair allocentric spatial memory. If we discuss these results within the interpretative frame suggested by the “Allocentric Lock Hypothesis” (Riva, 2012, 2014), we can hypothesize that altered serotoninergic activity in AN patients: (i) improves their ability to store and consolidate negative autobiographical memories, including those of their body, in allocentric perspective; (ii) impairs their ability to trigger voluntary inhibition of the previously stored negative memory of the body; (iii) impairs their capacity to retrieve/update allocentric information. Taken together, these points suggest a possible link between serotonin dysfunctions, memory impairments and BIDs: the impossibility of updating a disturbed body memory using real time experiential data—I'm locked to a wrong body stored in long term memory—pushes AN patients to control body weight and shape even when underweight.

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Role of 5-HT5A receptors in the consolidation of memory

Cited by 41 publications

References 26 publications

Prion Protein Modulates Monoaminergic Systems and Depressive-like Behavior in Mice

Prion Protein Modulates Monoaminergic Systems and Depressive-like Behavior in Mice

Structure and function of serotonin G protein-coupled receptors

Neurobiology of Anorexia Nervosa: Serotonin Dysfunctions Link Self-Starvation with Body Image Disturbances through an Impaired Body Memory

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