Role of 5-HT1A receptors in the modulation of stress-induced lactate metabolism in the medial prefrontal cortex and basolateral amygdala

Abstract

These results indicate that the foot shock stress-induced increase in lactate metabolism is partly regulated by 5-HT(1A) receptors both in cortical and limbic regions.

Serotonin-1A Receptors and Cognitive Enhancement in Schizophrenia: Role for Brain Energy Metabolism

“…In particular, acute administration of tandospirone led to a significant increase in extracellular lactate concentrations, and reduced the footshock stress-induced lactate increment in the mPFC in rats (Uehara et al 2006). Taken together, it was hypothesized that transient blockade of NMDA receptors during the neonatal stage (modeling schizophrenia) would inhibit energy demands in response to stress in the mPFC at the young adult stage, and that 5-HT 1A partial agonist, such as tandospirone, would reverse the effect of the neonatal insult on energy metabolism.…”

“…Footshock stress was administered using a plastic communication box, according to the method described previously (Uehara et al, 2006). The box (L 51cm x W 51cm x H 40cm) was equipped with a grid floor, and was subdivided into nine compartments (17cm x17cm) by transparent plastic walls.…”

Role of glutamate transporters in the modulation of stress-induced lactate metabolism in the rat brain

“…Twenty minutes after the start of DHK perfusion, footshock stress was administered using a plastic communication box (CB5, MATYS, Toyama, Japan) according to the method in our previous reports (Uehara et al 2003b(Uehara et al , 2005(Uehara et al , 2006. The box (L 51 cm×W 51 cm×H 40 cm) was equipped with a grid floor composed of stainless steel rods (6-mm in diameter) placed 16 mm apart.…”

“…Extracellular lactate concentrations were measured by in vivo microdialysis technique with an enzyme reactor/ fluorometric detector according to the method previously reported (Uehara et al 2003a(Uehara et al , 2005(Uehara et al , 2006(Uehara et al , 2007. The animals were anesthetized with pentobarbital sodium (Nembutal, Abbott Laboratories, IL, USA; 40 mg/kg, i.p.…”

“…Monitoring with intracerebral microdialysis is an authentic method to assess the relationship between lactate metabolism and neurotransmission (Uehara et al 2003a(Uehara et al , 2005(Uehara et al , 2006(Uehara et al , 2007. We previously investigated the effect of physical and emotional stressors on extracellular lactate concentrations in the medial prefrontal cortex (mPFC) and basolateral amygdala (BLA; Uehara et al 2003aUehara et al , 2006Uehara et al , 2007, and found that these stressors induced an increase in lactate efflux in both brain regions. Although, little is known about the precise mechanism by which various types of stress cause an increase in extracellular lactate concentrations, it has been indicated that lactate release in the striatum after physiological stimulation is related to glutamate uptake (Demestre et al 1997).…”