Role of 3-Mercaptopyruvate Sulfurtransferase (3-MST) in Physiology and Disease

Rao, Swetha Pavani; Dobariya, Prakashkumar; Bellamkonda, Harshini; More, Swati S.

doi:10.3390/antiox12030603

Cited by 8 publications

(4 citation statements)

References 126 publications

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“…Our results showed that only 3MST expression was not boosted by taurine supplementation. Unlike other H 2 S-producing enzymes, 3MST is located in the mitochondria and catalyzes the production of H 2 S with 3-mercaptopyruvate as the donor of sulfur [31]. Further studies are required to investigate whether taurine differentially regulates H 2 S-producing enzyme expression for such reasons.…”

Section: Discussionmentioning

confidence: 99%

Protective Role of Taurine on Rat Offspring Hypertension in the Setting of Maternal Chronic Kidney Disease

Tain,

Hou,

Chang-Chien

et al. 2023

Antioxidants

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Taurine is a natural antioxidant with antihypertensive properties. Maternal chronic kidney disease (CKD) has an impact on renal programming and increases the risk of offspring hypertension in later life. The underlying mechanisms cover oxidative stress, a dysregulated hydrogen sulfide (H2S) system, dysbiotic gut microbiota, and inappropriate activation of the renin–angiotensin–aldosterone system (RAAS). We investigated whether perinatal taurine administration enables us to prevent high blood pressure (BP) in offspring complicated by maternal CKD. Before mating, CKD was induced through feeding chow containing 0.5% adenine for 3 weeks. Taurine was administered (3% in drinking water) during gestation and lactation. Four groups of male offspring were used (n = 8/group): controls, CKD, taurine-treated control rats, and taurine-treated rats with CKD. Taurine treatment significantly reduced BP in male offspring born to mothers with CKD. The beneficial effects of perinatal taurine treatment were attributed to an augmented H2S pathway, rebalance of aberrant RAAS activation, and gut microbiota alterations. In summary, our results not only deepen our knowledge of the mechanisms underlying maternal CKD-induced offspring hypertension but also afford us the impetus to consider taurine-based intervention as a promising preventive approach for future clinical translation.

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Section: Discussionmentioning

confidence: 99%

Protective Role of Taurine on Rat Offspring Hypertension in the Setting of Maternal Chronic Kidney Disease

Tain,

Hou,

Chang-Chien

et al. 2023

Antioxidants

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“…The human 3MST enzyme is encoded by the MPST gene on the long arm of chromosome 22 in the subtelomeric region q13.1 [ 125 ]. The MPST gene is 5.6 kbp in length with only two exon regions [ 126 ].…”

Section: H 2 S Enzymatic Machinerymentioning

confidence: 99%

Role of Hydrogen Sulfide in Oncological and Non-Oncological Disorders and Its Regulation by Non-Coding RNAs: A Comprehensive Review

Youness,

Habashy,

Khater

et al. 2024

ncRNA

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Recently, myriad studies have defined the versatile abilities of gasotransmitters and their synthesizing enzymes to play a “Maestro” role in orchestrating several oncological and non-oncological circuits and, thus, nominated them as possible therapeutic targets. Although a significant amount of work has been conducted on the role of nitric oxide (NO) and carbon monoxide (CO) and their inter-relationship in the field of oncology, research about hydrogen sulfide (H2S) remains in its infancy. Recently, non-coding RNAs (ncRNAs) have been reported to play a dominating role in the regulation of the endogenous machinery system of H2S in several pathological contexts. A growing list of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are leading the way as upstream regulators for H2S biosynthesis in different mammalian cells during the development and progression of human diseases; therefore, their targeting can be of great therapeutic benefit. In the current review, the authors shed the light onto the biosynthetic pathways of H2S and their regulation by miRNAs and lncRNAs in various oncological and non-oncological disorders.

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“…The 3-Mercaptopyruvate Sulfurtransferase (3-MST), in conjunction with cysteine aminotransferase (CAT), 3-MST, also produces H 2 S. The CAT/3-MST pathway is a significant source of H 2 S in the brain and vascular endothelial cells [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

Hydrogen Sulfide: An Emerging Regulator of Oxidative Stress and Cellular Homeostasis—A Comprehensive One-Year Review

Munteanu,

Turnea,

Rotariu

2023

Antioxidants

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Hydrogen sulfide (H2S), traditionally recognized as a toxic gas, has emerged as a critical regulator in many biological processes, including oxidative stress and cellular homeostasis. This review presents an exhaustive overview of the current understanding of H2S and its multifaceted role in mammalian cellular functioning and oxidative stress management. We delve into the biological sources and function of H2S, mechanisms underlying oxidative stress and cellular homeostasis, and the intricate relationships between these processes. We explore evidence from recent experimental and clinical studies, unraveling the intricate biochemical and molecular mechanisms dictating H2S’s roles in modulating oxidative stress responses and maintaining cellular homeostasis. The clinical implications and therapeutic potential of H2S in conditions characterized by oxidative stress dysregulation and disrupted homeostasis are discussed, highlighting the emerging significance of H2S in health and disease. Finally, this review underscores current challenges, controversies, and future directions in the field, emphasizing the need for further research to harness H2S’s potential as a therapeutic agent for diseases associated with oxidative stress and homeostatic imbalance. Through this review, we aim to emphasize H2S’s pivotal role in cellular function, encouraging further exploration into this burgeoning area of research.

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Role of 3-Mercaptopyruvate Sulfurtransferase (3-MST) in Physiology and Disease

Cited by 8 publications

References 126 publications

Protective Role of Taurine on Rat Offspring Hypertension in the Setting of Maternal Chronic Kidney Disease

Protective Role of Taurine on Rat Offspring Hypertension in the Setting of Maternal Chronic Kidney Disease

Role of Hydrogen Sulfide in Oncological and Non-Oncological Disorders and Its Regulation by Non-Coding RNAs: A Comprehensive Review

Hydrogen Sulfide: An Emerging Regulator of Oxidative Stress and Cellular Homeostasis—A Comprehensive One-Year Review

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