Role of 18F-FDG PET/CT in patients with pyrexia of unknown origin

Rao, Anuradha; Shirodkar, Kapil; Govindarajan, Mallarajapatna; Devaru, Siddalinga

doi:10.1016/j.jrid.2016.11.006

Cited by 1 publication

(32 citation statements)

References 20 publications

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“…Patients fasted for 4-6 h, rested for 30 min under a warm cushion before 3 MBq/kg 18 FDG was injected intravenously and had a resting uptake-period of 60 min. Patients were scanned from head to toe with 3 min per bed position using a Biograph mCT 128 scanner.…”

Section: Fdg-pet/ct Imagingmentioning

confidence: 99%

“…0.5 mSv) performed for the purposes of attenuation correction and anatomical correlation. Diagnostic CT with intravenous contrast was performed during the same procedure in case of non-physiological 18 FDG-PET uptake or known focal disease prior to referral. PET and fused PET/CT images were displayed on Siemens syngo via workstations for analysis.…”

Section: Fdg-pet/ct Imagingmentioning

confidence: 99%

“…[2][3][4] In adults with FUO, [fluorine-18]-fluoro-2deoxy-d-glucose positron-emission tomography/CT ( 18 FDG-PET/ CT), a method combining both anatomic and functional imaging, is increasingly used if standard investigations are non-diagnostic. 5 The diagnostic yield of 18 FDG-PET/CT in adults cannot be directly extrapolated to children, as the aetiology of unexplained fever vary between children and adults. 2,6,7 In children, very limited evidence is available for the use of 18 FDG-PET/CT in unexplained fever.…”

Section: Introductionmentioning

confidence: 99%

“…5 The diagnostic yield of 18 FDG-PET/CT in adults cannot be directly extrapolated to children, as the aetiology of unexplained fever vary between children and adults. 2,6,7 In children, very limited evidence is available for the use of 18 FDG-PET/CT in unexplained fever. 8 We here report the results of 18 FDG-PET/CT as diagnostic procedure in previously healthy children with unexplained fever during a 6-years period.…”

Section: Introductionmentioning

confidence: 99%

“…2,6,7 In children, very limited evidence is available for the use of 18 FDG-PET/CT in unexplained fever. 8 We here report the results of 18 FDG-PET/CT as diagnostic procedure in previously healthy children with unexplained fever during a 6-years period.…”

Section: Introductionmentioning

confidence: 99%

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Unexplained fever in children—Benefits and challenges of FDG‐PET/CT

et al. 2022

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Aim To explore [fluorine‐18]‐fluoro‐2‐deoxy‐d‐glucose positron‐emission‐tomography/computed tomography (18FDG‐PET/CT) in patients where standard investigations were non‐diagnostic. Methods We reviewed medical records of previously healthy children who had 18FDG‐PET/CT performed at Copenhagen University Hospital in 2015–2020 due to unexplained fever. Results Thirty‐five of 819 paediatric 18FDG‐PET/CT were performed due to unexplained fever. The final diagnoses were malignancy (11%), infections (23%), inflammatory diseases (43%) and miscellaneous (26%). 18FDG‐PET/CT was diagnostic in six cases with Takayasu's arteritis, tuberculosis, Langerhans cell histiocytosis and Ewing sarcoma. Sixteen cases had focal 18FDG‐uptake, but 18FDG‐PET/CT could only differentiate malignancy, infection and inflammation in three cases. In six cases with inflammatory diseases and no focal signs, PET/CT was normal except increased non‐specific 18FDG‐uptake in bone marrow and spleen in five cases. One case was false positive (suspicion of appendicitis) and two false negative (leukaemia and inflammatory disease). Conclusion 18FDG‐PET/CT was diagnostic, or contributed to the diagnosis, in several children with unexplained fever referred to a tertiary centre. Challenges comprised (i) only increased non‐specific 18FDG‐uptake in bone marrow and spleen in half of cases with inflammatory diseases, (ii) no differentiation between complicated infections, malignancy and inflammation in most cases with focal processes and (iii) a small risk of false positive and false negative results.

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Section: Fdg-pet/ct Imagingmentioning

confidence: 99%

Section: Fdg-pet/ct Imagingmentioning

confidence: 99%