Role Identification of Passiflora Incarnata Linnaeus : A Mini Review

Food Science & Nutrition

Yoon

et al. 2019

Social cost of insomnia in modern society is gradually increasing. Due to various social phenomena and lifestyles that take away the opportunity of good quality of sleep, problems of insomnia cannot be easily figured out. Prescription of sleeping pills for insomnia patients can cause other inconveniences due to their side effects beyond their intended purposes. On the other hand, Passiflora incarnata L. (PI) has been widely used in South America for several centuries, showing effectiveness for sleep, sedation, anxiety, and so on in the civilian population. However, reports on the treatment efficacy of this herbal medicinal plant for insomnia patients through standardization as a sleeping agent have been very rare. Therefore, we obtained leaves and fruits of PI (8:2 by weight) as powder to prepare an extract. It was then applied to C6 rat glioma cells to quantitate mRNA expression levels of GABA receptors. Its sleep‐inducing effect was investigated using experimental animals. PI extract (6 μg/ml) significantly decreased GABA receptors at 6 hr after treatment. Immobility time and palpebral closing time were significantly increased after single (500 mg/kg) or repeated (250 mg/kg) oral administration. In addition, blood melatonin levels were significantly increased in PI extract‐treated animals after both single and repeated administrations. These results were confirmed through several repeated experiments. Taken together, these results confirmed that PI extract had significant sleep‐inducing effects in cells and animals, suggesting that PI extract might have potential for treating human insomnia.

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Sleep‐inducing effect of Passiflora incarnata L. extract by single and repeated oral administration in rodent animals

Food Science & Nutrition

Yoon

et al. 2019

“…Insomnia itself is an adverse event, but very dangerous physical and mental changes caused by sleeping pills have also been reported [2,4,15,16,19,25,29,33]. Drinking tea made from passion flowers, particularly Passiflora incarnata, has long been known to provide stability and induce sleep [22]. It is classified as a very safe herb, registered as foods with the Korea Ministry of Food and Drug Safety (KFDA).…”

Section: Discussionmentioning

confidence: 99%

Chronic oral administration of Passiflora incarnata extract has no abnormal effects on metabolic and behavioral parameters in mice, except to induce sleep

2019

Lab Anim Res

Although the number of prescriptions and dependence on sleeping pills are increasing, the associations with unexpected abnormal behaviors and metabolic diseases caused by the overuse of sleeping pills are not well understood. In particular, such as abnormal eating-behavior and the occurrence of metabolic disorders caused by psychological unstable states are reported. For this reason, herbal medicine, which has not had such side effects in recent years, is attracting attention as an alternative medicine/food for sleeping inducer. We have used ethanol extracts from Passiflora incarnata (PI) to steadily obtain positive effects on sleep and brain microenvironment. However, as mentioned earlier, sleep-inducing efficacy can only be used safely if the behavioral and metabolic abnormalities do not appear. Thus, in this study, we used Phenomaster equipment to continuously monitor the movement, feeding, water consumption, gas changes, etc. in C57BL/6 mice at a dose of 500 mg/kg/day for 5 consecutive days with PI extract group compared with the control group. Before sacrifice, differences in body composition of mice were also compared. Monitoring of 24 h/5 days through the equipment showed no change in PI-treated group in anything except for significant decrease in blood melatonin levels and activity after PI administration. Taken together, the statistically insignificance of any behavioral and metabolic phenomenon produced by repeated treatment of PI are not only expected to have an accurate sleep effect, but are also free of side effects of the prescribed sleeping pills. This study has given us greater confidence in the safety of the PI extracts we use for sleep-inducer.

“…In recent, oriental herbal pharmacy has been got attention as alternative medications for treating insomnia that can help relieved hypertension, cognitive function and improve sleep induction for seeking to increase safety and efficiency. Passiflora incarnate L ., Rosmarinus officinalis L ., Violet oil from Viola odrata , Ziziphus spinose , Poria cocos , Gycyrrhiza uralensis are recently introduced for sedative effect for well sleep 5556. These herbal medicine is known to act through GABA or GABA-A receptor 56.…”

Section: Possible Causative Factors Of Bone Mass Deficit In Subjects mentioning

confidence: 99%

“…In particular, effect of Passiflora spp. extract recently reported they have possibility to use as sleep inducer and anti-osteoporosis substance 5557. In recent, Passiflora incarnate L .…”

Section: Possible Causative Factors Of Bone Mass Deficit In Subjects mentioning

confidence: 99%

Sharing Pathological Mechanisms of Insomnia and Osteoporosis, and a New Perspective on Safe Drug Choice

Chung

2018

J Menopausal Med

Lack of adequate sleep has become increasingly common in our 24/7 modern society. Reduced sleep has significant health consequences including metabolic and cardiovascular disorders, and mental problems including depression. In addition, although the increase in life expectancy has provided a dream of longevity to humans, the occurrence of osteoporosis is a big obstacle to this dream for both male and female. It is known that insomnia and bone health problems, which are very critical conditions in human life, interestingly, share a lot of pathogenesis in recent decades. Nevertheless, due to another side effects of the synthetic drugs being taken for the treatment of insomnia and osteoporosis, patients have substantial anxiety for the safety of drugs with therapeutic expectation. This review examines the pathogenesis shared by sleep and osteoporosis together and herbal medicine, which has recently been shown to be safe and efficacious in the treatment of both diseases other than synthetic drugs. We suggestions for how to treat osteoporosis. These efforts will be the first step toward enabling patients to have comfortable and safe prescriptions through a wide selection of therapeutic agents in the future.