Role for the enteric nervous system in the regulation of satiety via cholecystokinin-8

Effects of cholecystokinin-receptor antagonists on Fos-like immunoreactivity stimulated by sulfated cholecystokinin-8 in neurons of the myenteric plexus and hindbrain of rats

“…In addition, analysis of the data reported here confirmed the finding that sulfated CCK-8 increases the amount of Fos-LI in enteric and hindbrain neurons through only CCK 1 R. 1,[5][6][7][8][9][10][11][12][13] The overall goal of the study reported here and another study 7 conducted by our laboratory group was to evaluate the role of the enteric nervous system in functions evoked by CCK. This study was an extension of other studies 1,6-8,10-13 conducted by our laboratory group and provided immunohistochemical evidence that 3 dosages of L365,260, a specific CCK 2 R antagonist, failed to atten-uate Fos-LI in myenteric or hindbrain neurons activated by sulfated CCK-8.…”

“…1 Other cells also secrete CCK (eg, neuroendocrine cells and neurons in the CNS and peripheral nervous system, including neurons in the myenteric plexus of the gastrointestinal tract). 1 Other cells also secrete CCK (eg, neuroendocrine cells and neurons in the CNS and peripheral nervous system, including neurons in the myenteric plexus of the gastrointestinal tract).…”

“…1 Other cells also secrete CCK (eg, neuroendocrine cells and neurons in the CNS and peripheral nervous system, including neurons in the myenteric plexus of the gastrointestinal tract). 1 On the other hand, the CCK 2 R mediates the role of CCK in memory, learning, anxiety, panic attacks, and gastric acid and histamine release. 1 For example, the CCK 1 R mediates gallbladder contractions, exocrine pancreatic secretion, inhibition of gastric emptying, and satiety.…”

“…Cholecystokinin binds 2 guanosine triphosphate-binding protein (ie G-protein)-coupled receptors (CCK 1 receptor [CCK 1 R] and CCK 2 receptor [CCK 2 R]) to evoke numerous responses. 1,2 The distribution of CCK 1 R and CCK 2 R overlaps. 1 On the other hand, the CCK 2 R mediates the role of CCK in memory, learning, anxiety, panic attacks, and gastric acid and histamine release.…”

“…[5][6][7][8][9] In addition, CCK and nutrients that release CCK increase Fos-LI in certain neurons in the myenteric and submucosal plexuses of the duodenum and jejunum but not the ileum and colon in rats. 1,[6][7][8][10][11][12][13] This activation is mediated by CCK 1 R. 7 However, the role of CCK 2 R in the increase of Fos-LI in these neurons as a result of stimulation by CCK has not been determined.…”