Role for Excitatory Amino Acids in Methamphetamine-Induced Nigrostriatal Dopaminergic Toxicity

Sonsalla, Patricia K.; Nicklas, William J.; Heikkila, Richard E.

doi:10.1126/science.2563176

Cited by 472 publications

(243 citation statements)

References 33 publications

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“…Cortico-striatal fibers are the main glutamatergic input to the neostriatum, and increased striatal glutamate sustains a deleterious effect on nigrostriatal DA axon terminals [68, 183]. …”

Section: The Role Of Ne On Methamphetamine-induced Dopaminergic Toxicitymentioning

confidence: 99%

The Effects of Locus Coeruleus and Norepinephrine in Methamphetamine Toxicity

Ferrucci

Giorgi

Bartalucci

et al. 2013

Current Neuropharmacology

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The activity of locus coeruleus (LC) neurons has been extensively investigated in a variety of behavioural states. In fact this norepinephrine (NE)-containing nucleus modulates many physiological and pathological conditions including the sleep-waking cycle, movement disorders, mood alterations, convulsive seizures, and the effects of drugs such as psychostimulants and opioids. This review focuses on the modulation exerted by central NE pathways on the behavioural and neurotoxic effects produced by the psychostimulant methamphetamine, essentially the modulation of the activity of mesencephalic dopamine (DA) neurons. In fact, although NE in itself mediates some behavioural effects induced by methamphetamine, NE modulation of DA release is pivotal for methamphetamine-induced behavioural states and neurotoxicity. These interactions are discussed on the basis of the state of the art of the functional neuroanatomy of central NE- and DA systems. Emphasis is given to those brain sites possessing a remarkable overlapping of both neurotransmitters.

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“…Cortico-striatal fibers are the main glutamatergic input to the neostriatum, and increased striatal glutamate sustains a deleterious effect on nigrostriatal DA axon terminals [68, 183]. …”

Section: The Role Of Ne On Methamphetamine-induced Dopaminergic Toxicitymentioning

confidence: 99%

The Effects of Locus Coeruleus and Norepinephrine in Methamphetamine Toxicity

Ferrucci

Giorgi

Bartalucci

et al. 2013

Current Neuropharmacology

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“…Several drugs of abuse increase extraneuronal dopamine in dopaminergic nerve terminals in the striatum (Pereira et al, 2004(Pereira et al, , 2006a. Dopamine and excitatory amino acids were suggested to play an important role in the nigrostriatal dopaminergic damage induced by methamphetamine (Schmidt et al, 1985;Sonsalla et al, 1989). Interestingly, there is a marked difference in specificity between methamphetamine and MDMA regarding the neurotransmitter systems and, consequently, the brain areas affected by each of these compounds.…”

Section: Drugs Of Abuse and The Brainmentioning

confidence: 99%

Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs

Cunha‐Oliveira

Rego

Oliveira

2008

Brain Research Reviews

193

136

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“…ID) did not change over the en tire time course of ischemia and reperfusion. As .. reduces neurodegeneration produced by metham phetamine (Sonsalla et al , 1989) and ischemia/ reperfusion injury (Simon et al , 1984), and blocks…”

Section: Mrna Analysismentioning

confidence: 99%

Modulation of Ornithine Decarboxylase mRNA following Transient Ischemia in the Gerbil Brain

Dempsey¹,

Carney

Kindy

1991

J Cereb Blood Flow Metab

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Summary: Ornithine decarboxylase (ODC) is the rate limiting enzyme that catalyzes the synthesis of poly amines from ornithine and is thought to be involved in the cellular response to growth, differentiation, and stress. Previous studies have demonstrated that transient cere bral ischemia results in an increase in ODC activity and polyamine synthesis. We have used the Mongolian gerbil as a model system to test the hypothesis that the cellular response to ischemia induces a distinct pattern of ODC gene expression. Our results indicate that transient isch emia, induced by bilateral carotid occlusion, elevates ODC mRNA within 1-4 h after reperfusion, which corre lates with increased ODC activity and polyamine synthe-The biochemical and physiological significance of polyamine biosynthesis in cellular growth has been well characterized in both prokaryotes and eukary otes. The polyamines have been shown to be asso ciated with cell proliferation, differentiation, and growth (Pegg and McCann, 1982;Pegg, 1986) Abbreviations used: CREB, cyclic AMP-responsive element binding protein; ODC, ornithine decarboxylase; SDS, sodium dodecyl sulfate; SSC, 3 M NaC1I0.3 M sodium citrate. 979sis. Increased ODC mRNA can be detected in the fore brain, striatum, hippocampus, and midbrain but not the cerebellum, which is not subject to ischemic injury. In contrast, c-fos mRNA increased by 15 min after reperfu sion and actin mRNA did not demonstrate alterations in level after ischemia. Pentobarbital prevented the increase in ODC mRNA, whereas the glutamate antagonist MK-801 had no effect on the elevation of ODC gene expres sion after ischemia. We conclude that the ischemia induced increase in ODC enzyme activity may be attrib uted in part to transcriptional activation of the ODC gene.

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Role for Excitatory Amino Acids in Methamphetamine-Induced Nigrostriatal Dopaminergic Toxicity

Cited by 472 publications

References 33 publications

The Effects of Locus Coeruleus and Norepinephrine in Methamphetamine Toxicity

The Effects of Locus Coeruleus and Norepinephrine in Methamphetamine Toxicity

Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs

Modulation of Ornithine Decarboxylase mRNA following Transient Ischemia in the Gerbil Brain

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