Role for early-differentiated natural killer cells in infectious mononucleosis

Azzi, Tarik; Lünemann, Anna; Murer, Anita; Ueda, Seigo; Béziat, Vivien; Malmberg, Karl‐Johan; Staubli, Georg; Gysin, Claudine; Berger, Christoph; Münz, Christian; Chijioke, Obinna; Nadal, David

doi:10.1182/blood-2014-01-553024

Cited by 164 publications

(260 citation statements)

References 58 publications

(55 reference statements)

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“…To date, apart from HCMV, no other viruses have been seen to correlate with the appearance of adaptive NK cells, and associated KIR repertoire deviations, including herpes simplex virus (both HSV‐1 and HSV‐2) and varicella‐zoster virus 160, 169. Instead, it was shown that acute Epstein–Barr virus infection induces NKG2A + CD57 + expansion lacking KIR expression 170. Altogether, these findings suggest that KIR, and adaptive NK cells, might have mainly evolved to control HCMV.…”

Section: Kir Gene Expressionmentioning

confidence: 99%

Deciphering the killer‐cell immunoglobulin‐like receptor system at super‐resolution for natural killer and T‐cell biology

et al. 2016

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SummaryKiller‐cell immunoglobulin‐like receptors (KIRs) are components of two fundamental biological systems essential for human health and survival. First, they contribute to host immune responses, both innate and adaptive, through their expression by natural killer cells and T cells. Second, KIR play a key role in regulating placentation, and hence reproductive success. Analogous to the diversity of their human leucocyte antigen class I ligands, KIR are extremely polymorphic. In this review, we describe recent developments, fuelled by methodological advances, that are helping to decipher the KIR system in terms of haplotypes, polymorphisms, expression patterns and their ligand interactions. These developments are delivering deeper insight into the relevance of KIR in immune system function, evolution and disease.

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Section: Kir Gene Expressionmentioning

confidence: 99%

Deciphering the killer‐cell immunoglobulin‐like receptor system at super‐resolution for natural killer and T‐cell biology

et al. 2016

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“…1,2 Recently, Azzi et al described the role of early differentiated NK cells in Epstein-Barr virus-driven infectious mononucleosis (IM). 3 Besides the conventional CD56 bright CD16 Figure 1A). Blood samples were obtained from 9 pediatric HSCT recipients and 4 healthy donors with written informed consent and approval by the Institutional Review Board (protocol P02.099).…”

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confidence: 99%

CD56dimCD16− NK cell phenotype can be induced by cryopreservation

Lugthart

Dam

Tol

et al. 2015

Blood

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“…Interestingly, and in contrast to the prototypic terminally differentiated NK cell-expanding pathogen HCMV, EBV seems to drive the proliferation of early differentiated non-KIR-educated NK cells (25,27). These NK cells have been reported to recognize B cells that lytically replicate EBV via recognition by the activating NK cell receptors NKG2D and DNAM-1 (28), and the respective ligands for these receptors seem to be upregulated during transition from latent to lytic EBV infection (25,28). Loss of NK cells leads to elevated viral loads of WT, but not lytic replication-incompetent, EBV in vivo (26).…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, donors were disparate for HLA-A2 expression, which allowed us to track the progeny of specific donors in mixed reconstitution lial malignancies through its viral oncogenes that are expressed during latent infection, lytic replication that produces infectious virions seems to be poorly controlled during IM and causes the characteristic immune pathogenic CD8 + T cell lymphocytosis of this disease (23). NK cells were reported to expand during IM (21,24,25) and seem to particularly restrict lytic EBV infection that is deregulated during IM (25,26). Interestingly, and in contrast to the prototypic terminally differentiated NK cell-expanding pathogen HCMV, EBV seems to drive the proliferation of early differentiated non-KIR-educated NK cells (25,27).…”

Section: Resultsmentioning

confidence: 99%

“…NK cells were reported to expand during IM (21,24,25) and seem to particularly restrict lytic EBV infection that is deregulated during IM (25,26). Interestingly, and in contrast to the prototypic terminally differentiated NK cell-expanding pathogen HCMV, EBV seems to drive the proliferation of early differentiated non-KIR-educated NK cells (25,27). These NK cells have been reported to recognize B cells that lytically replicate EBV via recognition by the activating NK cell receptors NKG2D and DNAM-1 (28), and the respective ligands for these receptors seem to be upregulated during transition from latent to lytic EBV infection (25,28).…”

Section: Resultsmentioning

confidence: 99%

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Cognate HLA absence in trans diminishes human NK cell education

Landtwing

Raykova

Pezzino

et al. 2016

Journal of Clinical Investigation

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NK cells are innate lymphocytes with protective functions against viral infections and tumor formation. Human NK cells carry inhibitory killer cell Ig-like receptors (KIRs), which recognize distinct HLAs. NK cells with KIRs for self-HLA molecules acquire superior cytotoxicity against HLA- tumor cells during education for improved missing-self recognition. Here, we reconstituted mice with human hematopoietic cells from donors with homozygous KIR ligands or with a mix of hematopoietic cells from these homozygous donors, allowing assessment of the resulting KIR repertoire and NK cell education. We found that co-reconstitution with 2 KIR ligand-mismatched compartments did not alter the frequency of KIR-expressing NK cells. However, NK cell education was diminished in mice reconstituted with parallel HLA compartments due to a lack of cognate HLA molecules on leukocytes for the corresponding KIRs. This change in NK cell education in mixed human donor-reconstituted mice improved NK cell-mediated immune control of EBV infection, indicating that mixed hematopoietic cell populations could be exploited to improve NK cell reactivity against leukotropic pathogens. Taken together, these findings indicate that leukocytes lacking cognate HLA ligands can disarm KIR+ NK cells in a manner that may decrease HLA- tumor cell recognition but allows for improved NK cell-mediated immune control of a human γ-herpesvirus

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Role for early-differentiated natural killer cells in infectious mononucleosis

Cited by 164 publications

References 58 publications

Deciphering the killer‐cell immunoglobulin‐like receptor system at super‐resolution for natural killer and T‐cell biology

Deciphering the killer‐cell immunoglobulin‐like receptor system at super‐resolution for natural killer and T‐cell biology

CD56dimCD16− NK cell phenotype can be induced by cryopreservation

Cognate HLA absence in trans diminishes human NK cell education

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