Role for Cyclooxygenase 2 in the Development and Maintenance of Neuropathic Pain and Spinal Glial Activation

Takeda, Kenji; Sawamura, Shigehito; Tamai, Hisayoshi; Sekiyama, Hiroshi; Hanaoka, Kazuo

doi:10.1097/00000542-200510000-00023

Cited by 48 publications

(37 citation statements)

References 34 publications

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“…started 7 days after ligation partially reversed NP but not glial activation. This data suggests that spinal prostaglandin production by spinal COX-2 plays a pivotal role in the development of neuropathic pain, however, it is not critical for the maintenance of such pain [32].…”

Section: Meloxicam In Nerve Damage Modelsmentioning

confidence: 87%

“…Distribution and metabolism of celecoxib in rats is similar to in humans through a single metabolic pathway. Celecoxib has analgesic and anti-inflammatory effects in patients with rheumatoid arthritis and no effect on COX-1 activity at therapeutic plasma concentrations [25,31,32]. In past studies, efficacy of several selective COX-2 inhibitors using chemically-and physically-induced peripheral nerve injury in animal research models has been reported.…”

Section: Discussion Study 1: Indomethacin and Celecoxibmentioning

confidence: 99%

“…infusion started immediately after spinal nerve ligation controlled the development of mechanical allodynia and thermal hyperalgesia. However, treatment started a week after nerve ligation could not reverse established NP [32]. Meloxicam administration shown to reduce SCI-induced oxidative stress, exert neural protection by inhibiting lipid peroxidation, deplete GSH, cause DNA fragmentation, and to improve the impairment of the neurological functions due to SCI [33].…”

Section: Thermal Hyperalgesia (Th) Pain Testmentioning

confidence: 98%

“…Meloxicam was to attenuate development and maintenance of both thermal hyperalgesia and mechanical allodynia induced by peripheral nerve injury [32]. Immediate administration of meloxicam injected i.t.…”

Section: Meloxicam In Nerve Damage Modelsmentioning

confidence: 99%

“…Immediate administration of meloxicam injected i.t. acted anti-development of mechanical allodynia and TH induced by spinal nerve ligation (SNL) [32]. However, treatment initiated a week following ligation could not reverse established NP and glial activation.…”

Section: Meloxicam In Nerve Damage Modelsmentioning

confidence: 99%

See 4 more Smart Citations

Immediate administration of COX inhibitors in spinal cord contusion injury and a current review of COX Therapy

Moran¹,

Sampene²,

Oakes³

et al. 2017

Med Res Innov

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Background: Neuropathic pain (NP) is a common complication during the late phase of spinal cord injury (SCI). The enzyme cyclooxygenase-2 (COX-2) shown to play a crucial role during the inflammatory early phase of SCI. We report here on the antihyperalgesic effects of three COX inhibitors: celecoxib, indomethacin and meloxicam used individually. Their efficacy and impact on mortality losses following administration of each treatment evaluated in the late phase of chronic NP post SCI.

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Section: Meloxicam In Nerve Damage Modelsmentioning

confidence: 87%

Section: Discussion Study 1: Indomethacin and Celecoxibmentioning

confidence: 99%

Section: Thermal Hyperalgesia (Th) Pain Testmentioning

confidence: 98%

Section: Meloxicam In Nerve Damage Modelsmentioning

confidence: 99%

Section: Meloxicam In Nerve Damage Modelsmentioning

confidence: 99%

See 3 more Smart Citations

Immediate administration of COX inhibitors in spinal cord contusion injury and a current review of COX Therapy

Moran¹,

Sampene²,

Oakes³

et al. 2017

Med Res Innov

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Synergistic antiallodynic interaction of the metamizol‐gabapentin combination

Ortega-Varela

Herrera

Caram-Salas

et al. 2009

Drug Development Research

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This study was designed to evaluate the possible antiallodynic interaction between metamizol and gabapentin in rats submitted to L5/L6 spinal nerve ligation. Metamizol, gabapentin, or a combination of both drugs were assessed after oral and intrathecal administration in neuropathic rats. Metamizol partially reduced tactile allodynia after intrathecal, but not oral, administration. Conversely, gabapentin reduced tactile allodynia in a dose-dependent manner after both administration routes. Oral administration of a constant dose of metamizol (600 mg/kg) significantly increased the gabapentininduced antiallodynic effect. Moreover, the gabapentin ED 50 value was lower in the presence than in the absence of metamizol. Intrathecal co-administration of metamizol and gabapentin in a dose-fixed ratio (0.5:0.5) reduced tactile allodynia in rats. The theoretical ED 30 value for the spinal combination estimated from the isobologram was 118.4712 mg, whereas that experimental ED 30 value was 66.2710.1 mg indicating a synergistic interaction. Results indicate that metamizol, a cyclo-oxygenase 2 inhibitor, is able to reduce tactile allodynia as well to increase the antiallodynic effect of gabapentin in the neuropathic rat. This combination could be useful to treat neuropathic pain in humans. Drug Dev

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Investigating the ameliorative effect of alpha‐mangostin on development and existing pain in a rat model of neuropathic pain

Razavi

Hosseinzadeh

2020

Phytotherapy Research

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Mangosteen fruit has been used for various disorders, including pain. The effects of alpha-mangostin, the main component of mangosteen, on the neuropathic pain caused by chronic constriction injury (CCI) were evaluated in rats. In treatment groups, alpha-mangostin (10, 50, 100 mg/kg/day, i.p.) was administered from Day 0, the day of surgery, for 14 days. The degree of heat hyperalgesia, cold, and mechanical allodynia was assessed on Days 0, 3, 5, 7, 10, and 14. The lumbar spinal cord levels of MDA, GSH, inflammatory markers (TLR-4, TNF-α, MMP2, COX2, IL-1β, iNOS, and NO), apoptotic markers (Bcl-2, Bax, and caspase-3) were measured by western blot on Days 7 and 14. Rats in the CCI group showed thermal hyperalgesia, cold, and mechanical allodynia on Days 3-14. All concentrations of alpha-mangostin alleviated CCI-induced behavioral alterations. MDA level augmented and GSH level decreased in the CCI group and alpha-mangostin (50, 100 mg/kg) reversed the alterations. An enhancement in the levels of all inflammatory markers, Bax, and caspase-3 was shown on Days 7 and 14, which was controlled by alpha-mangostin (50 mg/kg). The detected antinociceptive effects of alpha-mangostin may be mediated through antioxidant, anti-inflammatory, and antiapoptotic properties.

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Role for Cyclooxygenase 2 in the Development and Maintenance of Neuropathic Pain and Spinal Glial Activation

Abstract: Spinal cyclooxygenase 2 mediates the development but not the maintenance of neuropathic pain and glial activation in rats. Peripheral cyclooxygenase 2 plays a part in the maintenance of neuropathic pain.

Cited by 48 publications

References 34 publications

Immediate administration of COX inhibitors in spinal cord contusion injury and a current review of COX Therapy

Immediate administration of COX inhibitors in spinal cord contusion injury and a current review of COX Therapy

Synergistic antiallodynic interaction of the metamizol‐gabapentin combination

Investigating the ameliorative effect of alpha‐mangostin on development and existing pain in a rat model of neuropathic pain

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