Rôle de l’histamine et des récepteurs histaminiques dans la pathogenèse du paludisme

Beghdadi, Walid; Porcherie, Adeline; Schneider, Bradley S.; Dubayle, David; Péronet, Roger; Huerre, Michel; Watanabe, Takeshi; Ohtsu, Hiroshi; Louis, Jacques; Mécheri, Salaheddine

doi:10.1051/medsci/2009254377

Cited by 7 publications

(4 citation statements)

References 27 publications

(26 reference statements)

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“…They also found increased plasma levels of histamine in severe malaria patients, further supporting their hypothesis [34]. Moreover, the involvement of histamine in CM has also recently been confirmed in a murine model [35-37]. In this study, histidine decarboxylase-deficient mice were unable to synthesize free histamine and did not develop CM after infection with P. berghei ANKA.…”

Section: Introductionsupporting

confidence: 82%

Host matrix metalloproteinases in cerebral malaria: new kids on the block against blood–brain barrier integrity?

Polimeni

Prato

2014

Fluids Barriers CNS

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Cerebral malaria (CM) is a life-threatening complication of falciparum malaria, associated with high mortality rates, as well as neurological impairment in surviving patients. Despite disease severity, the etiology of CM remains elusive. Interestingly, although the Plasmodium parasite is sequestered in cerebral microvessels, it does not enter the brain parenchyma: so how does Plasmodium induce neuronal dysfunction? Several independent research groups have suggested a mechanism in which increased blood–brain barrier (BBB) permeability might allow toxic molecules from the parasite or the host to enter the brain. However, the reported severity of BBB damage in CM is variable depending on the model system, ranging from mild impairment to full BBB breakdown. Moreover, the factors responsible for increased BBB permeability are still unknown. Here we review the prevailing theories on CM pathophysiology and discuss new evidence from animal and human CM models implicating BBB damage. Finally, we will review the newly-described role of matrix metalloproteinases (MMPs) and BBB integrity. MMPs comprise a family of proteolytic enzymes involved in modulating inflammatory response, disrupting tight junctions, and degrading sub-endothelial basal lamina. As such, MMPs represent potential innovative drug targets for CM.

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Section: Introductionsupporting

confidence: 82%

Host matrix metalloproteinases in cerebral malaria: new kids on the block against blood–brain barrier integrity?

Polimeni

Prato

2014

Fluids Barriers CNS

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“…role in inflammatory reactions recruited to the sites of inflammation and drive proinflammatory responses [29,30]. e present study, the ability of GIE to normalize the hematological parameters of WBC in the GIE-treated groups, especially at a dose of 500 mg/kg, showed that the extract had immunomodulatory, antioxidant, and anti-inflammatory effects.…”

Section: Discussionmentioning

confidence: 46%

“…Moreover, basophils and eosinophils were significantly increased in the untreated group, responsible for mediating inflammatory and cytotoxic events associated with malaria infection. Basophils play a crucial role in inflammatory reactions recruited to the sites of inflammation and drive proinflammatory responses [ 29 , 30 ]. The present study, the ability of GIE to normalize the hematological parameters of WBC in the GIE-treated groups, especially at a dose of 500 mg/kg, showed that the extract had immunomodulatory, antioxidant, and anti-inflammatory effects.…”

Section: Discussionmentioning

confidence: 99%

The Potential Role of Gymnema inodorum Leaf Extract Treatment in Hematological Parameters in Mice Infected with Plasmodium berghei

Ounjaijean

Sukati

Somsak

et al. 2021

Journal of Tropical Medicine

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Malaria remains a significant cause of death in tropical and subtropical regions by serious complications with hematological abnormalities consistent with high parasitemia. Hence, this study aimed to determine the efficacy of the Gymnema inodorum leaf extract (GIE) on hematological alteration in Plasmodium berghei infection in mice. Groups of ICR mice were infected intraperitoneally with parasitized red blood cells of P. berghei ANKA (PbANKA). They were administered orally by gavage of 100, 250, and 500 mg/kg of GIE for 4 consecutive days. Healthy and untreated groups were given distilled water, while 10 mg/kg of chloroquine was treated as the positive control. Hematological parameters including RBC count, hemoglobin (Hb), hematocrit (Hct), mean corpuscular volume (MCV), mean cell hemoglobin (MCH), mean cell hemoglobin concentration (MCHC), RBC distribution width (RDW), white blood cell (WBC) count, and WBC differential count were measured. The results showed that significant decreases of RBC count, Hb, Hct, MCV, MCH, MCHC, and reticulocytes were observed in the untreated group, while RDW was significantly increased compared with the healthy control. Furthermore, the WBC, neutrophil, monocyte, basophil, and eosinophil of untreated mice increased significantly, while the lymphocyte was significantly decreased compared with the healthy control. Interestingly, GIE normalized the hematological alteration induced by PbANKA infection in GIE-treated groups compared with healthy and untreated groups. The highest efficacy of GIE was observed at a dose of 500 mg/kg. Our results confirmed that GIE presented the potential role in the treatment of hematological alteration during malaria infection.

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“…Finally, the pyrimido[4,5‐ b ]indole scaffold, of which MMV006372 ( 604 ) is a member, has been reported as an inhibitor of histamine H 4 as well as human epidermal growth factor tyrosine kinase . Inhibition of histamine H 1 , H 2 and H 3 has been shown to play a role in obstructing malarial pathogenesis; the same has not been demonstrated for H 4 . Similarly, P. falciparum does not express tyrosine kinase; however, inhibition of erythrocyte tyrosine kinase has been proposed as a host‐specific malarial therapy …”

Section: Malariamentioning

confidence: 99%

Unpacking the Pathogen Box—An Open Source Tool for Fighting Neglected Tropical Disease

Veale

2019

ChemMedChem

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The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for their potential against several of the world's most important neglected tropical diseases, including trypanosomiasis, leishmaniasis, cryptosporidiosis, toxoplasmosis, filariasis, schistosomiasis, dengue virus and trichuriasis, in addition to malaria and tuberculosis. This library represents an ensemble of numerous successful drug discovery programmes from around the globe, aimed at providing a powerful resource to stimulate open source drug discovery for diseases threatening the most vulnerable communities in the world. This review seeks to provide an in‐depth analysis of the literature pertaining to the compounds in the Pathogen Box, including structure–activity relationship highlights, mechanisms of action, related compounds with reported activity against different diseases, and, where appropriate, discussion on the known and putative targets of compounds, thereby providing context and increasing the accessibility of the Pathogen Box to the drug discovery community.

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Rôle de l’histamine et des récepteurs histaminiques dans la pathogenèse du paludisme

Cited by 7 publications

References 27 publications

Host matrix metalloproteinases in cerebral malaria: new kids on the block against blood–brain barrier integrity?

Host matrix metalloproteinases in cerebral malaria: new kids on the block against blood–brain barrier integrity?

The Potential Role of Gymnema inodorum Leaf Extract Treatment in Hematological Parameters in Mice Infected with Plasmodium berghei

Unpacking the Pathogen Box—An Open Source Tool for Fighting Neglected Tropical Disease

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