Role and Regulation of Prostaglandin Synthesis in the Mitogenic Response of Ovarian Granulosa Cells to Transforming Growth Factor Alpha

Li, Julang; Li, Ming; Lafrance, Martine; Simmons, Denise R.; Tsang, Benjamin K.

doi:10.1007/978-1-4899-1813-0_76

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…It has been previously reported that PGE is capable of promoting proliferation in the chicken ovary (Li et al, 1997) (Figure 7c).…”

Section: Effects Of Pge 2 On the Growth Of Swfsmentioning

confidence: 55%

“…It has been previously reported that PGE is capable of promoting proliferation in the chicken ovary (Li et al, 1997). To investigate the impacts of PGE 2 on follicular development, we selected SWFs as a model.…”

Section: Effects Of Pge 2 On the Growth Of Swfsmentioning

confidence: 99%

“…Notably, it has been reported that both the prostaglandin E2 receptor (EP2) and the prostaglandin E4 receptor (EP4) play physiological roles or have therapeutic relevance in a number of major reproductive steps (Funk et al, 2014). Similarly, in nonmammalian species, such as birds, some physiological effects of PGE 2 and PGF 2α have been described; those related to oviposition and follicular development, for example, have been recognized for decades (Kwok, Wang, & Leung, 2012;Li, Li, Lafrance, Simmons, & Tsang, 1997;Manchanda, Kim, & Tsang, 2001;Takahashi, Tajima, Nakagawa-Mizuyachi, Nakayama, & Kawashima, 2011). Nevertheless, the functions of avian EPs have not yet been fully explained.…”

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confidence: 99%

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Promotion of the prehierarchical follicle growth by postovulatory follicles involving PGE₂–EP2 signaling in chickens

Lin

Liu

Guo

et al. 2018

Journal Cellular Physiology

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The postovulatory follicle (POF) in birds is an enigmatic structure, the function of which remains largely unknown. Previous studies on chickens have shown that removal of POFs leads to the postponement of oviposition and the disturbance of broody behavior. One suggestion is that POFs may secrete some crucial hormones or cytokines to act on reproductive organs. However, such secretions and their specific target organs remain to be identified. Here, we investigate the putative functions of POFs in promoting the development of prehierarchical follicles in chickens and explore the possible signaling mechanisms controlling these processes. Results show that POFs express steroidogenic acute regulatory protein (STAR), cholesterol side-chain cleavage enzyme (CYP11A1), cyclooxygenase 1 (COX1), and COX2 in granulosa cells (GCs), and, most notably, that POF1 produces more prostaglandin E2 (PGE ) or prostaglandin F2α than do the F1 follicle or the other POFs. Using coculture systems, we also found that POF1 or GCs from POF1 (POF1-GCs) significantly promote the proliferation of theca externa cells of small white follicles (SWFs, one phase of the prehierarchical follicle). Treatment with PGE significantly facilitates theca externa cell proliferation in SWFs. This POF-stimulating effect on SWF growth was prevented by treatment with indomethacin (COX inhibitor) or TG6-10-1 (PGE type 2 receptor [EP2] antagonist). Therefore, POF1 may secrete PGE to stimulate the progression of SWF by PGE -EP2 signaling. These results indicate that POF1 may serve as a transient supplementary endocrine gland in the chicken ovary that stimulates the development of the prehierarchical follicles through PGE -EP2 signaling.

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“…It has been previously reported that PGE is capable of promoting proliferation in the chicken ovary (Li et al, 1997) (Figure 7c).…”

Section: Effects Of Pge 2 On the Growth Of Swfsmentioning

confidence: 55%

Section: Effects Of Pge 2 On the Growth Of Swfsmentioning

confidence: 99%

mentioning

confidence: 99%

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Promotion of the prehierarchical follicle growth by postovulatory follicles involving PGE₂–EP2 signaling in chickens

Lin

Liu

Guo

et al. 2018

Journal Cellular Physiology

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Reproduction in the Female

Johnson

2015

Sturkie's Avian Physiology

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Steroidogenesis, proliferation and apoptosis in bovine granulosa cells: role of tumour necrosis factor-α and its possible signalling mechanisms

Basini

Mainardi²,

Bussolati³

et al. 2002

Reprod. Fertil. Dev.

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This study was designed to investigate the presence of bioactive tumour necrosis factor-alpha (TNF-alpha) in bovine fluid collected from small (<5 mm) and large (>8 mm) follicles, as well as the production of the cytokine by the granulosa cells collected from the same type of follicles. Moreover, the effectiveness of 10, 1 and 0.1 ng mL(-1) of human TNF-alpha (hTNF-alpha) in affecting the main parameters of granulosa cell function, progesterone (P4) and oestradiol-17beta (E2) production, cell proliferation and apoptosis, was tested. In addition, the study aimed to determine whether the signalling mechanisms of TNF-alpha in these cells involve cAMP, nitric oxide or prostaglandin E2 (PGE2) and F2alpha (PGF2alpha). It emerged that bioactive TNF-alpha is present in follicular fluid from both types of follicles and can be measured in media conditioned by granulosa cells from large follicles. As for the effects of hTNF-alpha, it inhibits P4 production in cells from both types of follicles and stimulates E2 output in those from small follicles; it does not affect proliferation, but it stimulates granulosa cell apoptosis. Finally, the effects of hTNF-alpha on bovine granulosa cells are not mediated by nitric oxide or cAMP, as neither of these substances were affected by treatment with the cytokine; however, in some way, they could be mediated through PGE2 and PGF2alpha, the production of which was inhibited by TNF-alpha in cells from small follicles.

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Role and Regulation of Prostaglandin Synthesis in the Mitogenic Response of Ovarian Granulosa Cells to Transforming Growth Factor Alpha

Cited by 3 publications

References 10 publications

Promotion of the prehierarchical follicle growth by postovulatory follicles involving PGE₂–EP2 signaling in chickens

Promotion of the prehierarchical follicle growth by postovulatory follicles involving PGE₂–EP2 signaling in chickens

Reproduction in the Female

Steroidogenesis, proliferation and apoptosis in bovine granulosa cells: role of tumour necrosis factor-α and its possible signalling mechanisms

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Role and Regulation of Prostaglandin Synthesis in the Mitogenic Response of Ovarian Granulosa Cells to Transforming Growth Factor Alpha

Cited by 3 publications

References 10 publications

Promotion of the prehierarchical follicle growth by postovulatory follicles involving PGE2–EP2 signaling in chickens

Promotion of the prehierarchical follicle growth by postovulatory follicles involving PGE2–EP2 signaling in chickens

Reproduction in the Female

Steroidogenesis, proliferation and apoptosis in bovine granulosa cells: role of tumour necrosis factor-α and its possible signalling mechanisms

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Product

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Promotion of the prehierarchical follicle growth by postovulatory follicles involving PGE₂–EP2 signaling in chickens

Promotion of the prehierarchical follicle growth by postovulatory follicles involving PGE₂–EP2 signaling in chickens