Role and Mechanisms of Phytochemicals in Hair Growth and Health

Abstract

Hair health is associated with personal distress and psychological well-being. Even though hair loss (alopecia) does not affect humans’ biological health, it affects an individual’s social well-being. So, treatment for hair problems and improving hair health are obligatory. Several pharmacological and cosmeceutical treatment procedures are available to manage hair loss and promote growth. Several factors associated with hair health include genetics, disease or disorder, drugs, lifestyle, chemical exposure, and unhealthy habits such as smoking, diet, and stress. Synthetic and chemical formulations have side effects, so people are moving towards natural compounds-based remedies for their hair problems. The history of using phytochemicals for hair health has been documented anciently. However, scientific studies on hair loss have accelerated in recent decades. The current review summarizes the type of alopecia, the factor affecting hair health, alopecia treatments, phytochemicals’ role in managing hair loss, and the mechanisms of hair growth-stimulating properties of phytochemicals. The literature survey suggested that phytochemicals are potent candidates for developing treatment procedures for different hair problems. Further detailed studies are needed to bring the scientific evidence to market.

A clinical investigation on the safety and effectiveness of an ayurvedic hair oil in controlling hair fall (khalitya) in healthy adult human subjects: a study on hair fall management

“…Studies on hair growth-promoting activities of phytochemicals have proved effective in managing hair loss. 21 The use of such naturally derived ingredients eliminates the side-effects, while providing the required therapeutic benefit. Likewise, it was observed that our test treatment-an ayurvedic hair oil, proved to work well in the management of hair fall.…”

Status of research on the development and regeneration of hair follicles

“…Although phytochemicals have potential for treating alopecia, they have several limitations, including the limited availability of clinical evidence, varying levels of effectiveness, and slow appearance of results. In addition, phytochemical treatments are less effective for individuals with more severe hair loss 145 . Controlled shampoo use and lifestyle modifications are more direct approaches to the prevention and treatment of hair loss than phytochemical use.…”

Peran Selenium dan Vitamin E pada Ruminansia: ulasan singkat

“…Hasil pada Tabel 2 menunjukkan gejala klinis dan perubahan patologis keracunan Se cukup bervariasi. Gejala klinis dapat berupa kekurusan, penurunan penampilan, kerusakan dan pertumbuhan abnormal kuku, kerontokan rambut, alopecia, gangguan reproduksi, dyspnea, sianosis dan kematian mendadak (Kim, 2001;Kesika et al, 2023). Sedangkan perubahan patologis ditunjukkan dengan adanya nekrosis miokardium, nekrosis otot skelet, edema paru paru, hidrotoraks, hidroperikardium, edema abdominal dan hemoragi mukosa usus (McKenzie & Al-Dissi, 2017).…”