This study delves into the potential benefits of barberry consumption on blood pressure in individuals with hypertension and its effects on various non-communicable diseases. Barberry was chosen for investigation due to its historical use in traditional medicine and emerging evidence suggesting its positive impact on health. Barberry contains bioactive compounds like berberine, which have been associated with cardiovascular health benefits such as lowering blood pressure and cholesterol levels. Given the rising prevalence of hypertension and other non-communicable diseases globally, understanding the potential therapeutic effects of barberry could offer novel preventive and therapeutic strategies. Through the systematic review and meta-analysis of relevant literature, this study aims to provide a comprehensive assessment of the efficacy of barberry in managing blood pressure and its implications for public health interventions targeting non-communicable diseases.